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Vol. 16. Issue 1.
Pages 7-11 (January - March 1980)
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Vol. 16. Issue 1.
Pages 7-11 (January - March 1980)
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Analisis citogenetico de exudados pleurales sospechosos de malignidad
Cytogenetical analysis of pleurai exudates of suspected malignancy
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L. García Quesada*, J.A. Portero Sánchez**, J.A. Cambronero Galache***
* Departamento de Genética. Fundación Jiménez. Díaz, Madrid
** Departamento de Genética. Fundación Jiménez. Díaz, Madrid
*** Departamento de Medicina Interna. Fundación Jiménez. Díaz, Madrid
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Resumen

Presentamos una nueva técnica para realizar el diagnóstico de malignidad en derrames pleurales sospechosos. Consiste en el análisis citogenético del exudado en busca de hiperdiploidia o marcadores cromosómicos. Se realizó la técnica sobre 14 muestras que, al tiempo, fueron estudiadas desde e punto de vista citológico e histológico.

En relación a la citología, ambos métodos revelaron similar fiabilidad; er ningún caso se obtuvieron falsos posi tivos, y en 2 se hallaron falsos negati vos, igual porcentaje que en la citología. De los 9 casos tumorales estudia dos, se hizo el diagnóstico en 7; de ellos, en 6 se halló hiperdiploidia en e porcentaje que exigía nuestro criteric de malignidad, y en 1 se hallaron marcadores cromosómicos.

El interés de esta técnica residiría er su rapidez, su fiabilidad y la búsquedr de marcadores cromosómicos específicos de cada proceso tumoral.

Summary

The authors present a new techniquf for carrying out the diagnosis o malignancy in suspicious pleura exudates. This technique consists ii cytogenetical analysis of the exudati searching for polyploidy or chromo somal markers. This technique wa; used for 14 samples which were alsc studied ar the same time from the cy tologic and histological point of view

In relation to cytology, both methoc revealed similar trustworthiness; in m case were false positives obtained, bu in two cases false negatives wen found, the same percentaje as that ii cytology. Of the nine cases of tumor: studied, the diagnosis was made in 7 Of these seven, polyploidy was founc in the percentage that the authors criteria of malignancy required, and ii one case chromosomal markers wen found.

The interest of this technique lies it its rapidity, reliability and the searcl for specific chromosomal markers o each tumorous process.

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Copyright © 1980. Sociedad Española de Neumología y Cirugía Torácica
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