Original Article
Effect of Carbocysteine on Exacerbations and Lung Function in Patients With Mild-to-Moderate Chronic Obstructive Pulmonary Disease: A Multicentre, Double-Blind, Randomized, Placebo-Controlled Trial
Yumin Zhoua,b,1, Fan Wua,1, Haiqing Lia,1, Zhishan Denga,1, Li Linc,1, Hong Huangd,1, Haiyan Zhaoe,1, Yiran Wangf,1, Lingwei Wangg,1, Qijian Chenh,1, Shan Caii,j,k,l,1, Zhiyi Hem, Yinghua Yingn, Peiyu Huanga, Heshen Tiana, Jieqi Penga, Shan Xiaoa, Xiang Wena, Huajing Yanga, Youlan Zhena..., Zihui Wanga, Ningning Zhaoa, Lifei Lua, Jianwu Xua, Qiuyue Wangc,
, Pixin Rana,b,
, for the China Carbocysteine in Mild-to-moderate COPD Study Group Ver más
Corresponding author
Corresponding author
a State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China
b Guangzhou Laboratory, Bio-land, Guangzhou, China
c Department of Pulmonary and Critical Care Medicine, Institute of Respiratory Disease, The First Hospital of China Medical University, Shenyang, China
d Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
e Respiratory Department of Tianjin Medical University General Hospital, Tianjin, China
f The First Hospital of Wenzhou Medical University, Wenzhou, China
g Department of Pulmonary and Critical Care Medicine, Shenzhen Institute of Respiratory Diseases, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong Province, China
h Department of Respiratory Medicine, School of Medicine, Ruijin North Hospital, Shanghai Jiao Tong University, Shanghai, China
i Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
j Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China
k Clinical Medical Research Center for Pulmonary and Critical Care Medicine in Hunan Province, Changsha, Hunan, China
l Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China
m Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
n Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
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