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Vol. 31. Issue 8.
Pages 410-414 (October 1995)
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Vol. 31. Issue 8.
Pages 410-414 (October 1995)
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Utilidad del 99mTc-tetrofosmin en el diagnóstico de tumoraciones pulmonares. Valoración preliminar
The ussefulness of 99mTc-tetrofosmin in the diagnosis of lung tumors. A preliminary assessment
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N. Novoa*,1, M.J. Tabuenca**, A. Varela*, M. Mar Córdoba*, J.L. Ortiz Berrocal**, R. Montz***
* Servicio de Cirugía Torácica y Cardiovascular. Madrid
** Servicio de Medicina Nuclear. Clínica Puerta de Hierro. Madrid
*** Department of Nuclear Medicine. University Hospital, Hamburg, Eppendorf, Alemania
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Estudiamos de forma preliminar la captación del nuevo radiofármaco 99mTc-tetrofosmin en carcinomas primarios de pulmón. Se analizan los resultados de los 5 casos estudiados de forma preoperatoria con tomografía tipo SPECT pulmonar (según las siglas internacionales). Los hallazgos de imagen se contrastan con los resultados de la cirugía. El tamaño de las tumoraciones oscilaba entre 3,5 y 9 cm. Las imágenes obtenidas, en todos los casos, demuestran una satisfactoria captación del radiotrazador por la neoplasia que se define claramente del tejido pulmonar normal adyacente sin hallarse signos de interferencia por estructuras contiguas captantes del 99mTc-tetrofosmin (corazón e hígado) gracias a la resolución espacial de las tomografías. Dados los resultados preliminares de este estudio, podemos afirmar que la SPECT pulmonar, utilizando el 99mTc-tetrofosmin, puede ser una herramienta útil en el diagnóstico clínico de las tumoraciones malignas pulmonares, aunque se necesita seguir investigando para valorar el alcance de este hallazgo.

Palabras clave:
99mTc-Tetrofosmin
SPECT
Carcinoma broncogénico

We conducted a preliminar) study of captation of the new radiopharmaceutical 99mTc-tetrofosmin in cases of primary carcinoma of the lung, analyzing the results of 5 cases studied before surgery with single photon emission tomography (SPECT) of the lung. The results obtained by imaging were compared with those from surgery. Tumor size ranged between 3.S and 9 cm. In all cases the images showed that captation of the radiotracer by the neoplasm was satisfactory, leaving the area of the tumor clearly distinguishable from normal adjacent lung tissue and giving no signs of interference caused by absorption of 99mTc-tetrofosmin by contiguous structures (heart or liver). Based on these preliminar) results we assert that SPECT of the lung using 99mTc-tetrofosmin may be useful in the clinical diagnosis of malignant lung tumors, although further research must determine to what extent the technique can be relied upon.

Key words:
99mTc-tetrofosmin
SPECT
Bronchogenic carcinoma
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Bibliografía
[1.]
R. Okada, D. Glover, T. Gaffney, S. Williams.
Myocardial Kinetics of Te 99m-hexaquis-2-methoxy-2-methulpropylisonitrile.
Circulation, 77 (1988), pp. 491-498
[2.]
I.M. Hassan, A. Sahweil, C. Constantinides, A. Mahmoud, M. Nair, Y.T. Omar, H.M. Abdel-dayem.
Uptake and kinetics of Tc-99m hexakiis 2-methoxy isobutyl isonitrile in benign and malignant lesions in the lung.
Clin Nuci Med, 14 (1989), pp. 333-340
[3.]
S.T. Muller, B. Guth-Tougelides, H. Creutzig.
Imaging of malignant tumors with Tc-99m-MIBI SPECT [resumen].
J Nuci Med, 28 (1987), pp. 562
[4.]
L. Delmon-Moigeon, D. Piwica-Worms, B.L. Holman, M. Lawamura, A. Davison, A.G. Jones.
Comparison of 99m-Tc-MIBI in vitro tumor cell labeling [resumen].
J Nucl Med, 30 (1989), pp. 938
[5.]
J.C. Maublant, Zheng Zhang, M. Rapp, M. Ollier, J. Michelot, A. Veyre.
In vitro uptake of Technetium-99m-Teboroxime in carcinoma cell lines and normal cells: comparison with Technetium-99m-sestamibi and thallium-201.
J Nucí Med, 34 (1993), pp. 1.949-1.952
[6.]
M.L. Chiu, J.F. Kronauge, D. Piwica-Worms.
Effect of mitochondrial and plasma membrane potentials on accumulation of hexaquis (2-methoxyisobutylisonitrile) technetium (I) in cultured mouse fibroblasts.
J Nucl Med, 31 (1990), pp. 1.646-1.653
[7.]
B. Higley, F.W. Smith, T. Smith, H.G. Gemmell, P. Das-Gupta, D.V. Gvozdanovic, D. Graham, D. Hinge, J. Davidson, A. Lahiri.
Technetium-99m-l, 2-bis (bis[2-ethoxtyethyl] phospino) ethane: human biodistribution, dosimetry and safety of a new myocardial perfusion imaging agent.
J Nucl Med, 34 (1993), pp. 30-38
[8.]
M. Salvatore, L. Carratu, E. Porta.
Thallium-201 as a positive indicator for lung neoplasm: Preliminary experiments.
Radiology, 121 (1976), pp. 487
[9.]
P.A. Carvalho, M.L. Chiu, J.F. Kronauge, M. Kawamura, A.G. Jones, B.L. Holman, D. Piwica-Worms.
Subcellular distribution and analysis of technetium 99m-MIBI in isolated perfused rat hearts.
J Nucl Med, 33 (1992), pp. 1.516-1.521
[10.]
G. Le Bouthillier, R. Taillefer, R. Lambert, G. Bavaria, A. Duranceau, E. Lafontaine, M. Pellerin, J. Leveille.
Detection of primary lung cancer with 99mTc-sestamibi [resumen].
J Nucl Med, 35 (1993), pp. 140
[11.]
A. Sahweil, R. Milroy, J.H. Mckillop.
Thallium-201 chloride in the staging of lung cancer. Abstract presented at the British Nuclear.
Medicine Annual Meeting, (1987),
Copyright © 1995. Sociedad Española de Neumología y Cirugía Torácica
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