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Se presenta el caso de un paciente con un tumor carcinoide tímico atípico diagnosticado por mediastinotomía anterior y biopsia, tras un hallazgo casual en una radiografía del tórax. La determinación de una serie de marcadores neuroendocrinos, destacando la cromogranina, la citoqueratina, la sinaptofisina y la enolasa neuroespecífica, fue reveladora en el diagnóstico. El tratamiento efectuado consistió en cirugía de exéresis completa y radioterapia al lecho mediastínico (50 Gy) por su carácter infiltrante. Se estudian y revisan la incidencia, las características de presentación clínica, los métodos diagnósticos y terapéuticos y el pronóstico de estos tumores.
Palabras clave:
Tumor carcinoide tímico
Tumor neuroendocrino
Marcadores neuroendocrinos
We report a mate patient with atypical carcinoid tumor diagnosed by anterior mediastinotomy and biopsy after a mass was observed by chance on a chest film. The presence of neuroendocrine markers, notably chromogranin, cytokeratin, synapto-physin and neuro-specific enolase, facilitated diagnosis. Because the tumor was infiltrative, full surgical excision and radiotherapy to the mediastinum (50 Gy) were provided. We describe the incidence, clinical presentation, diagnosis, treatment and prognosis of these tumors.
Keywords:
Carcinoid tumor of the thymus
Neuroendocrine tumor
Neuroendocrine markers
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