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Vol. 61. Issue 8.
Pages 484-489 (August 2025)
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Vol. 61. Issue 8.
Pages 484-489 (August 2025)
Original Article
Persistent Blood Eosinophilia and Eosinopenia: Relationship with Outcomes in Bronchiectasis
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Grace Osculloa,n, Amina Bekkia,n, Casilda Olveirac, Rosa Girónd, Marta García-Clementee, Luis Máizf, Oriol Sibilag, Rafael Golpeh, Juan Luis Rodríguez-Hermosai, Esther Barreirob,j, Raúl Méndeza,b, Concepción Pradosk, Juan Rodríguez-Lópezl, David de la Rosam, Miguel Ángel Martínez-Garcíaa,b,n,
a Servicio de Neumología, Hospital Universitario y Politécnico La Fe, Valencia, Spain
b CIBERES de Enfermedades Respiratorias, ISCIII, Madrid, Spain
c Servicio de Neumología, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA)/Universidad de Málaga, Málaga, Spain
d Servicio de Neumología, Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, Madrid, Spain
e Servicio de Neumología, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
f Servicio de Neumología, Hospital Ramón y Cajal, Universidad de Alcalá de Henares, Madrid, Spain
g Servicio de Neumología, Hospital Clínico, Barcelona, Spain
h Servicio de Neumología, Hospital Lucus Augusti, Lugo, Spain
i Servicio de Neumología, Hospital San Carlos, Madrid, Spain
j Servicio de Neumología, Hospital del Mar-IMIM, UPF, CIBERES, Barcelona, Spain
k Servicio de Neumología, Hospital La Paz, Madrid, Spain
l Servicio de Neumología, Hospital San Agustín, Avilés, Asturias, Spain
m Servicio de Neumología, Hospital Santa Creu i Sant Pau, Barcelona, Spain
n Instituto de Investigaciones Salud La Fe de Valencia, Spain
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Tables (4)
Table 1. Absolute Numbers (Eosinophils/μL) in Peripheral Blood Samples in Three Consecutive Measures in the Persistent and Non-persistent Eosinophilic/Eosinopenic Groups.
Tables
Table 2. Comparison Between the Groups With and Without Persistent Eosinophilia.
Tables
Table 3. Comparison Between the Groups With and Without Persistent Eosinopenia.
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Table 4. Comparison Between the Groups With Persistent Eosinophilia and Persistent Eosinopenia.
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Abstract
Introduction

Blood eosinophil counts (BEC) have been related to the severity of bronchiectasis and its response to inhaled corticosteroids. However, only the baseline BEC has been used to assess this relationship and it is known that BEC could change over time. The objective of this study is to analyse the association of persistent eosinophilia or eosinopenia with outcomes in bronchiectasis.

Methods

Multicentre, prospective and observational study from 43 centres in Spain derived from the Spanish Bronchiectasis Registry (RIBRON). Asthma and anti-eosinophil treatments were excluded. Patients with at least two yearly BEC measures (including the baseline measure) were included. Persistent eosinophilia (at least 300cells/μL) or persistent eosinopenia (less than 100cells/μL) were defined as the persistence in the same eosinophil group after three yearly measures (being the baseline the first measure).

Results

Five hundred two patients with at least three BEC measures were included; 24.5% and 16.6% presented baseline eosinophilia or eosinopenia, respectively. Of these, 57.7% and 56.6% presented persistent eosinophilia and eosinopenia, respectively. Patients with persistent eosinophilia presented greater severity and a higher number/greater severity of exacerbations than those with non-persistent eosinophilia and those with persistent or non-persistent eosinopenia. Finally, patients with non-persistent eosinopenia presented more severity and a higher number/greater severity of exacerbations than those with non-persistent eosinophilia.

Conclusion

When only the baseline BEC was taken into account, patients with eosinopenia presented greater severity than those with eosinophilia. However, patients with persistent eosinophilia presented greater severity than those with persistent eosinopenia. Monitoring the BEC seems to be important in bronchiectasis.

Keywords:
Eosinophils
Bronchiectasis
Severity
Exacerbations
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