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Vol. 21. Issue 1.
Pages 4-8 (January - February 1985)
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Vol. 21. Issue 1.
Pages 4-8 (January - February 1985)
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Desarrollo de una nueva constante de difusion no afectada por cambios en el volumen alveolar
A new diffusion constant not affected by changes in alveolar volume
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N. Gonzalez Mangado, J. Vallejo Galbete, F. Lahoz Navarro
Sección de Fisiopatología Respiratoria. Servicio de Neumología. Fundación Jiménez Díaz. Madrid
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Se presenta una nueva constante de difusión poco afectada por los cambios del volumen alveolar (Va) en un mismo sujeto, al contrario de lo que ocurre con el Kco. Esta constante relaciona el DLco medido con el Va al que se efectúa la prueba, la constante «Zco» responde a la fórmula:

                 Zco=DLco medida×100/DLco ZSiendo DLco−Z=DLco teórica×Z

Z=2·X321+X32X=Va medido/TLC teórica

Se efectúa un estudio en ocho sujetos normales a tres diferentes volúmenes alveolares, comprobándose una menor variación de este parámetro en comparación de la DLco clásica y la Kco.

Se dan los valores de dos aplicaciones en pacientes y una tabla para derivar el factor «Z» en función de «X».

A new diffusion constant which in contrast with Kco is but little affected by changes in the alveolar volume (AV) in the same patient. This constant related the DLco measured with the AV of the test; the constant «Zco» expressed as:

                 Zco=DLco measured×100/DLco-Zif DLco-Z=DLco theoretically×Z

Z=2·X321+X32X=Va measured/TLC theoretically

In a study including eight healthy individuals tested at three different AV there was less variation in this parameter than in the classical DLco and Kco.

The values for two tests with patients are given as is a table to derive the «Z» and «X» factors.

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Bibliografia
[1.]
J.B. Cadigan, A. Marks, M.F. Ellicott, R.H. Jones, E.A. Gaensler.
An analysis of factors affecting the measurement of pulmonary diffusing capacity by the single breath method.
J Clin Invest, 40 (1961), pp. 1495
[2.]
G.H. Gurtner, W.S. Fowler.
Interrelationship of factors affecting pulmonarv diffusing eapaeity.
J Appl Physiol, 30 (1971), pp. 619
[3.]
J.M. Miller, R.E. Johnson.
Effect of lung inflation on pulmonary diffusing eapaeity at rest and exereise.
J Clin Invest, 45 (1966), pp. 493
[4.]
N.A.J. Flainer.
Variations in the eomponents of the diffusing eapaeity as the lung expands.
Clin Sei, 24 (1963), pp. 275
[5.]
N. González Mangado, F. Lahoz Navarro.
Factores que afectan al factor de transferencia para el CO en el pulmón con especial referencia a cambios en el volumen alveolar.
Arch Bronconeumol, 3 (1982), pp. 152-155
[6.]
D.J. Lipscomb, K. Patel, J.M.B. Hughes.
Interpretation of increases in the transfer coefficient for carbon monoxide (TLco/Va or Kco).
Thorax, 33 (1978), pp. 728
[7.]
J. Gil, E.R. Weibel.
Morphological study of pressure-volume hysteresis in rat lungs fixed by vascular perfusion.
Respiraron Physiology, 15 (1972), pp. 190
[8.]
T.G. Klingele, W.C. Slaub.
Alveolar shape changes with volume in isolated air-filled lobes of cal lung.
J Appl Phvsiol, 28 (1970), pp. 411
Copyright © 1985. Sociedad Española de Neumología y Cirugía Torácica
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