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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La metaplasia peribronquiolar es una lesi&#243;n histol&#243;gica caracterizada por fibrosis y proliferaci&#243;n del epitelio bronquiolar&#44; que afecta a las paredes alveolares peribronquiales y a los bronqu&#237;olos terminales&#46; Se considera una reacci&#243;n tisular inespec&#237;fica secundaria a la acci&#243;n de factores externos&#44; tales como el humo del tabaco y agentes microbianos&#46; Es un hallazgo histol&#243;gico frecuente en diversas enfermedades pulmonares intersticiales difusas&#46; Recientemente se han descrito algunos casos de enfermedad pulmonar intersticial difusa con manifestaciones cl&#237;nicas&#44; radiol&#243;gicas y de funci&#243;n respiratoria propias de las neumon&#237;as intersticiales idiop&#225;ticas en que la &#250;nica alteraci&#243;n histol&#243;gica era la presencia de metaplasia peribronquial&#46; En el presente art&#237;culo se describen 2 casos de neumopat&#237;a intersticial donde el &#250;nico hallazgo anatomopatol&#243;gico era la metaplasia peribronquiolar&#46;</p>"
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Vol. 45. Issue 1.
Pages 57-59 (January 2009)
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Vol. 45. Issue 1.
Pages 57-59 (January 2009)
Case Report
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Diffuse Interstitial Lung Disease Related to Peribronchiolar Metaplasia
Enfermedad pulmonar intersticial difusa por metaplasia peribronquiolar
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Esteban Cano-Jiméneza,
Corresponding author
estebanmallorca@gmail.com

Corresponding author.
, María Molina-Molinaa, José Ramírezb, Marcelo Sánchezc, Joan Lluís Aliagd, Antoni Xaubeta
a Servicio de Neumología, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
b Servicio de Anatomía Patológica, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
c Servicio de Radiodiagnóstico, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
d Servicio de Neumología, Hospital de Barcelona-SCIAS, Barcelona, Spain
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Abstract

Peribronchiolar metaplasia is a histologic lesion characterized by fibrosis and bronchiolar epithelial proliferation, affecting peribronchiolar alveolar septa and terminal bronchioles. It has been considered a nonspecific tissue reaction secondary to the action of external factors, such as tobacco smoke and microbes, and is a common histologic finding in several diffuse interstitial lung diseases. Several such cases with clinical, radiologic, and lung function manifestations characteristic of idiopathic interstitial pneumonia have been described recently, all having peribronchiolar metaplasia as the only histologic abnormality. We report 2 cases of interstitial lung disease in which peribronchiolar metaplasia was the only finding of pathology.

Keywords:
Diffuse interstitial lung disease
Idiopathic interstitial pneumonia
Peribronchiolar metaplasia
Resumen

La metaplasia peribronquiolar es una lesión histológica caracterizada por fibrosis y proliferación del epitelio bronquiolar, que afecta a las paredes alveolares peribronquiales y a los bronquíolos terminales. Se considera una reacción tisular inespecífica secundaria a la acción de factores externos, tales como el humo del tabaco y agentes microbianos. Es un hallazgo histológico frecuente en diversas enfermedades pulmonares intersticiales difusas. Recientemente se han descrito algunos casos de enfermedad pulmonar intersticial difusa con manifestaciones clínicas, radiológicas y de función respiratoria propias de las neumonías intersticiales idiopáticas en que la única alteración histológica era la presencia de metaplasia peribronquial. En el presente artículo se describen 2 casos de neumopatía intersticial donde el único hallazgo anatomopatológico era la metaplasia peribronquiolar.

Palabras clave:
Enfermedades pulmonares intersticiales difusas
Neumonías intersticiales idiopáticas
Metaplasia peribronquiolar
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Copyright © 2009. Sociedad Española de Neumología y Cirugía Torácica
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