Case Report
Diffuse Interstitial Lung Disease Related to Peribronchiolar Metaplasia
Enfermedad pulmonar intersticial difusa por metaplasia peribronquiolar
Esteban Cano-Jiméneza,
, María Molina-Molinaa, José Ramírezb, Marcelo Sánchezc, Joan Lluís Aliagd, Antoni Xaubeta
Corresponding author
a Servicio de Neumología, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
b Servicio de Anatomía Patológica, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
c Servicio de Radiodiagnóstico, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
d Servicio de Neumología, Hospital de Barcelona-SCIAS, Barcelona, Spain
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Clínic, Universitat de Barcelona, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Servicio de Radiodiagnóstico, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Servicio de Neumología, Hospital de Barcelona-SCIAS, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad pulmonar intersticial difusa por metaplasia peribronquiolar" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-11-13" "fechaAceptado" => "2007-11-20" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec155453" "palabras" => array:3 [ 0 => "Diffuse interstitial lung disease" 1 => "Idiopathic interstitial pneumonia" 2 => "Peribronchiolar metaplasia" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155454" "palabras" => array:3 [ 0 => "Enfermedades pulmonares intersticiales difusas" 1 => "Neumonías intersticiales idiopáticas" 2 => "Metaplasia peribronquiolar" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Peribronchiolar metaplasia is a histologic lesion characterized by fibrosis and bronchiolar epithelial proliferation, affecting peribronchiolar alveolar septa and terminal bronchioles. It has been considered a nonspecific tissue reaction secondary to the action of external factors, such as tobacco smoke and microbes, and is a common histologic finding in several diffuse interstitial lung diseases. Several such cases with clinical, radiologic, and lung function manifestations characteristic of idiopathic interstitial pneumonia have been described recently, all having peribronchiolar metaplasia as the only histologic abnormality. We report 2 cases of interstitial lung disease in which peribronchiolar metaplasia was the only finding of pathology.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La metaplasia peribronquiolar es una lesión histológica caracterizada por fibrosis y proliferación del epitelio bronquiolar, que afecta a las paredes alveolares peribronquiales y a los bronquíolos terminales. Se considera una reacción tisular inespecífica secundaria a la acción de factores externos, tales como el humo del tabaco y agentes microbianos. Es un hallazgo histológico frecuente en diversas enfermedades pulmonares intersticiales difusas. Recientemente se han descrito algunos casos de enfermedad pulmonar intersticial difusa con manifestaciones clínicas, radiológicas y de función respiratoria propias de las neumonías intersticiales idiopáticas en que la única alteración histológica era la presencia de metaplasia peribronquial. En el presente artículo se describen 2 casos de neumopatía intersticial donde el único hallazgo anatomopatológico era la metaplasia peribronquiolar.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| 2013 September | 66 | 13 | 79 |
| 2013 August | 61 | 11 | 72 |
| 2013 July | 81 | 17 | 98 |
| 2013 June | 65 | 6 | 71 |
| 2013 May | 65 | 7 | 72 |
| 2013 April | 54 | 5 | 59 |
| 2013 March | 7 | 2 | 9 |
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