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Vol. 34. Issue 5.
Pages 250-255 (May 1998)
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Vol. 34. Issue 5.
Pages 250-255 (May 1998)
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Resultados del tratamiento quirúrgico del carcinoma broncopulmonar no microcítico en estadio III-A
Results of surgical treatment of stage III-A non-small cell bronchopulmonary carcinoma
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A.I. Blanco*, A. Alvarado, J. Vázquez, M. Torres Cansino
Servicio de Cirugía Torácica. Hospital Universitario Virgen del Rocío. Sevilla
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Los objetivos de este estudio han sido analizar los resultados y la supervivencia del tratamiento quirúrgico en los distintos subgrupos del estadio III-A.

Desde enero de 1970 a diciembre de 1991, se revisaron 748 historias clínicas de pacientes con carcinoma broncopulmonar no microcítico. Seleccionamos 121 correspondientes a enfermos resecados que se encontraban en estadio III-A, según el informe anatomopatológico de la pieza.

La supervivencia global a los 3, 5 y 10 años fue de un 26, 16 y 12%, respectivamente. El subgrupo que mejor respondió al tratamiento fueron los T-3 (periféricos), N-0, con supervivencias a los 5 años del 21%. Si existía afectación de ganglios peribronquiales y/o hiliares (N-l), la supervivencia fue ligeramente inferior, alcanzando un 16%, y si se acompañaban de adenopatías mediastínicas (N-2) no se obtuvieron supervivientes a los 3 años. En este mismo subgrupo T-3, pero con invasión neoplásica de pericardio, pleura mediastínica o bronquios principales, no obtuvimos supervivencia alguna a los 3 años. La supervivencia obtenida en los pacientes T-3 periféricos que fueron sometidos a una resección en bloque fue del 27, 20 y 17% a los 3, 5 y 10 años, respectivamente, y del 16% a los 2 años y de 0% a los cinco en aquellos en los que se realizó una resección extrapleural.

Los enfermos que peor respondieron al tratamiento fueron aquellos con afectación de ganglios mediastínicos (N-2), en los que la supervivencia fue de un 17,12 y 8% a los 3, 5 y 10 años, respectivamente. En 34 de estos pacientes que fueron irradiados postoperatoriamente sobre el mediastino, la supervivencia aumentó discretamente al 16%.

En nuestra serie, la supervivencia obtenida a los 5 años para los carcinomas epidermoides fue similar a la de los adenocarcinomas, el 18 y el 14% a los 5 años, respectivamente.

Los resultados del tratamiento quirúrgico son variables y dependen de una serie de factores: extensión y localización extrapulmonar de las lesiones, técnica quirúrgica utilizada en los T-3 y tipo histológico tumoral.

Palabras clave:
Tratamiento quirúrgico
Carcinoma broncopulmonar no microcítico
Estadio III-A

To analyze results and survival after surgical treatment of various stage III-a subgroups.

We reviewed 748 case histories of patients with non-small cell bronchopulmonary carcinoma between January 1970 and December 1991, selecting 121 patients who underwent resection of stage III-a tumors, according to the pathologist's report.

Overall survival at 3, 5 and 10 years was 26, 16 and 12%, respectively. The subgroup with better response to treatment was that of patients with T-3 tumors (peripheral), N-0, with survival of 21% at five years. If peribronchial and/or hilar (N-1) nodes were affected, survival was slightly less (16%). If mediastinal adenopathy (N-2) was present, there were no survivors after 3 years. In this same T-3 group, but with neoplastic invasion of the pericardium, mediastinal pleura or principal bronchi, survival after 3 years was nil. The survival rates of peripheral T-3 patients undergoing block resections were 27, 20 and 17% at 3, 5 and 10 years, respectively, 16% at 2 years and 0% at 5, for those with extrapleural resection.

Patients with the poorest response to treatment were those with mediastinal nodes (N-2), in whom survival was 17, 12 and 8% at 3, 5 and 10 years, respectively. In the 34 patients received postoperative irradiation of the mediastinum, survival was 16% higher.

The survival rates after 5 years were similar for epidermoid carcinoma (18%) and adenocarcinoma (14%).

The results of surgical treatment are variable and depend on several factors: extension and extrapulmonary location of lesions, surgical technique used for T-3 tumors and histological type.

Key words:
Surgical treatment
Non-small cell bronchopulmonary carcinoma
Stage III-A
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Bibliografía
[1.]
C.F. Mountain.
A new international staging system for lung cancer.
Chest, 89 (1986), pp. 225-233
[2.]
G. Patterson, R. Ilves, R. Ginsberg, et al.
The value of adjuvant radiotherapy in pulmonary and chest wall resection for bronchogenic carcinoma.
Ann Thorac Surg, 34 (1982), pp. 692-697
[3.]
J. Astudillo, C. Conill.
Role of postoperative radiation therapy in stage III-a non small cell lung cancer.
Ann Thorac Surg, 50 (1990), pp. 618-623
[4.]
American Joint Committee on Cancer Lung.
Manual for staging of cancer, 3.a, pp. 115-121
[5.]
International Union Against Cancer (UICC).
Lung tumors (ICD-0162).
TNM clasification of malignant tumors, 4.a, pp. 69-73
[6.]
Grupo de trabajo SEPAR sobre carcinoma broncogénico.
Normativa sobre nomenclatura y clasificación del carcinoma broncogénico.
Ediciones Doyma S.A, (1986),
[7.]
J.M. Bereder, J. Mouroux, D. Benchimol, et al.
Stage III lung cancer.
Ann Chir Thorac Cardiovasc, 45 (1991), pp. 679-682
[8.]
C.F. Mountain.
Expanded possibilities for surgical treatment of lung cancer.
Survival in stage III-a disease. Chest, 97 (1990), pp. 1.045-1.051
[9.]
F. Rea, M. Loy, F. Calabro, et al.
II carcinoma polmonare III stadio: risultati a distanza della terapia chirurgica.
Acta Chir, 47 (1991), pp. 950-959
[10.]
T. Naruke, T. Goya, R. Tsuchiya, et al.
Prognosis and survival in resected lung carcinoma based on the new International staging system.
J Thorac Cardiovasc Surg, 96 (1988), pp. 440-447
[11.]
M. Robustellini, F. Massera, G. Rossi, et al.
Surgical treatment of stage III-a lung cancer. A retrospective review.
Siena: 2 nd European Conference of General Thoracic Surgery, (1994), pp. 132
[12.]
G. Ratto, G. Piacenza, C. Frola, et al.
Chest wall involvement by lung cancer: computed tomographic detection and results of operation.
Ann Thorac Surg, 51 (1991), pp. 182-188
[13.]
V. Cangemi, P. Volpino, N. D’Andrea, et al.
Results of surgical treatment of stage III-a non small cell lung cancer.
Eur J Cardiothorac Surg, 9 (1995), pp. 352-359
[14.]
J.M. Phieler, P.C. Pairolero, L. Weiland, et al.
Bronchogenic carcinoma with chest wall invasion.
Factors affecting survival following en bloc resection. Ann Thorac Surg, 34 (1982), pp. 684-692
[15.]
M.D. Martini Nael, J.M.D. Robert, R.M.D. Ginsberg.
Surgical approach to non small cell lung cancer stage Ill-a.
Hematology/Oncology Clinics of North America, 4 (1990), pp. 1.121-1.131
[16.]
Y. Watanabe, J. Shimizu, M. Oda, et al.
Results of surgical treatment in patients with HI-a non small cell lung cancer.
Thorac Cardiovasc Surg, 39 (1991), pp. 44-49
[17.]
L. López, L. López Pujol, A. Varela, et al.
Surgical treatment of stage III non small cell bronchogenic carcinoma involving the chest wall.
Scand J Thorac Cardiovasc Surg, 26 (1992), pp. 129-133
[18.]
C. Pitz, A. Brutel de la Rivière, H.R.J. Elbers, et al.
Surgical treatment of 125 patients with non small cell lung cancer and chest wall involvement.
Thorax, 51 (1996), pp. 846-850
[19.]
M. Casillas, F. París, V. Tarrazona, et al.
Surgical treatment of lung carcinoma involving the chest wall.
Eur J Cardiothorac Surg, 3 (1989), pp. 425-429
[20.]
V.F. Trastek, P.C. Pairolero, J.M. Phieler, et al.
En bloc (non hest walcl) resection for bronchogenic carcinoma with parietal fixation.
Factors affecting survival. J Thorac Cardiovasc Surg, 87 (1984), pp. 352-358
[21.]
M.S. Allen, D.J. Mathisen, H.C. Grillo, et al.
Bronchogenic carcinoma with chest wall invasion.
Ann Thorac Surg, 51 (1991), pp. 948-951
[22.]
H.C. Grillo, J.J. Greenberg, E.W. Wilkins, et al.
Resection of bronchogenic carcinoma involving thoracic wall.
J Thorac Cardiovasc Surg, 51 (1966), pp. 417-421
[23.]
B. Mc Caughan, N. Martini, M. Bains, et al.
Chest wall invasion in carcinoma of the lung. Therapeutic and prognostic implications.
J Thorac Cardiovasc Surg, 89 (1985), pp. 836-841
[24.]
C.F. Mountain.
Surgery for stage IIIa- N2 non small cell lung cancer.
Cancer, 73 (1994), pp. 2.589-2.598
[25.]
P. Goldstrow, G. Mannam, D. Kaplan, et al.
Surgical management of non small cell lung cancer with ipsilateral mediastinal metastase (N2 disease).
J Thorac Cardiovasc Surg, 107 (1994), pp. 19-28
[26.]
N. Martini.
Results of surgical treatment for N2 lung carcinoma. Curr Topics in Surgical Oncology.
Masson, (1991), pp. 33-42
[27.]
J. Naruke, K. Suemasu, S. Ishikawa.
Lymph node mapping and curability at various levels of metastasis in resected lung cancer.
J Thorac Cardiovasc Surg, 76 (1987), pp. 832-839
[28.]
Y. Watanabe, Y. Hayashi, J. Shimizu, et al.
Mediastinal nodal involvement and the prognosis of non small cell lung cancer.
Chest, 100 (1991), pp. 422-428
[29.]
Y. Watanabe, J. Shimizu, M. Oda, et al.
Aggresive surgical intervention in N2 non small cell cancer of the lung.
Ann Thorac Surg, 51 (1991), pp. 253-261
[30.]
F. Vara Cuadrado.
El N2 en el cáncer de pulmón: una frontera en litigio.
Arch Bronch, 30 (1994), pp. 121-123
[31.]
Y. Watanabe, J. Shimizu, M. Oda, et al.
Improved survival in left non small cell N2 lung cancer after more extensive operative procedure.
Thorac Cardiovasc Surg, 39 (1991), pp. 89-94
[32.]
N. Martini, B.J. Flehinger.
The role of surgery of N2 lung cancer.
Surg Clin North Am, 67 (1987), pp. 1.037-1.049
[33.]
J. Durán, J.J. González, R. Agüero, et al.
Pronóstico de la infiltración ganglionar mediastínica (N2) en pacientes con carcinoma de pulmón de células no microcelulares (CPCNM) intervenidos con intenciones curativas.
Arch Bronch, 30 (1994), pp. 196-201
[34.]
D.E. Van Raemdonck, A. Schneider, R.J. Ginsberg.
Surgical treatment for higher stage non small cell lung cancer.
Ann Thorac Surg, 54 (1992), pp. 999-1.013
Copyright © 1998. Sociedad Española de Neumología y Cirugía Torácica
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