Journal Information
Original Article
N-acetylcysteine Treatment in Chronic Obstructive Pulmonary Disease (COPD) and Chronic Bronchitis/Pre-COPD: Distinct Meta-analyses
Alberto Papia,
, Franco Alfanoa, Tommaso Bigonia, Lorenzo Mancinib, Amal Mawassb, Federico Baraldia, Cristina Aljamac, Marco Contolia, Marc Miravitllesc
Corresponding author
a Department of Translational Medicine, University of Ferrara Medical School, University of Ferrara, Sant’Anna University Hospital, Ferrara, Italy
b Alira Health S.r.l., 20121 Milan, Italy
c Pneumology Department, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
Highlights
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Treatment effects on PROs in chronic bronchitis (CB) with/out COPD are scarcely known.
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N-acetylcysteine (NAC) improve symptoms and/or QoL in studies conducted in CB.
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NAC reduce exacerbations in studies conducted in subjects with CB.
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Similarly, NAC reduce exacerbations and improve symptoms and/or QoL in COPD studies.