Journal Information
Vol. 12. Issue 2.
Pages 92-94 (April - June 1976)
Share
Share
Download PDF
More article options
Vol. 12. Issue 2.
Pages 92-94 (April - June 1976)
Full text access
Efectos de una asociacion hipotensora conteniendo propranolol sobre las vias aereas de hipertensos sin y con patologia bronquial
The effects of an hypotensor drug containing propanolol on the airways of hipertensives with and without bronchial pathology
Visits
3832
J. Maldonado Díaz de Losada, L. Monés Pujol-Busquets, B. Vicens Sagrera, R. Frouchtman
Hospital de la Santa Cruz y San Pablo Servicio de Asmatología y Alergia
This item has received
Article information
Abstract
Bibliography
Download PDF
Statistics
Resumen

Los fármacos β-bloqueantes, además de su acción hipotensora por todos bien conocida, provocan a nivel pulmonar un aumento en las resistencias de las vías aéreas.

Se ha querido valorar la posibilidad de utilización en hipertensos afectos de bronquitis de una asociación hipotensora conteniendo propranolol.

Se han estudiado 24 sujetos afectos de hipertensión esencial, 12 sin enfermedad broncopulmonar concomitante, 6 con bronquitis crónica y 6 afectos de bronquitis crónica espástica.

Se llega a la conclusión que el preparado formado por propranolol, hidraliza y un diurético, puede administrarse sin mayor cuidado en enfermos sin enfermedad pulmonar, con controles periódicos en enfermos con bronquitis crónica simple y se desaconseja su uso en sujetos con bronquitis espástica.

Summary

β -adrenoceptor blocking drugs, besides their well-known hypertensive action, cause an increase in the pulmonary airways resistance.

The authors have tested the possibilities of using an hypotensor drug containing propanolol in hypertensives with bronchitis.

Twenty-four subjects with essential hypertension, including 12 without concommitant bronchopulmonary disease, 6 with chronic bronchitis, and 6 with spastic bronchitis were studied.

The conclusion is drawn that a preparation of propanolol, hydralazine and a diuretic, can be administered freely to patients without pulmonary involvement, with periodic Controls to patients with chronic bronchitis, but its use is not advised for patients with spastic bronchitis.

Full text is only aviable in PDF
Bibliografía
[1.]
B.N.C. Prichard.
Treatment of hypertension with propranolol Brit.
Med. J., 1 (1969), pp. 7
[2.]
H.J. Waal.
Hipotensive action of propranolol Clin.
Pharmacol. Ther., 7 (1966), pp. 588
[3.]
L. Hansson, A. Zweifler.
The effect of propranolol on plasma renin activity and blood pressure in mild essential hypertension Acta Med.
Scand., 195 (1974), pp. 397
[4.]
F. Buhler, J. Laragh, L. Baer, E.D. Vaughan, H. Brunner.
Porpranolol inhibition of renin secretion.
New Engl. J. Med., 287 (1972), pp. 1209
[5.]
E. Brayo, R. Tarazi, H. Dustan.
On the mechanism of suppressed plasma-renin activity during beta-adrenergic blockade with propranolol J.
Lab. Clin. Med., 83 (1974), pp. 119
[6.]
Maldonado, J. Tratamiento de la hipertensión con propranolol asociado a hidralazina y un diurético tiazídico. Primeros resultados. Pendiente de publicación. Rev. Clin. Esp.
[7.]
R.S. Mc Neil, C. Ingram.
Effects of propranolol on ventilatory function.
Am. J. Cardiol., 18 (1966), pp. 473
[8.]
P.S. Richardson, M. Sterling.
Effects of S-adrenergic receptor blockade on airway conducíante and lung volume in normal and asthmatic subjects.
Brit. Med. J., 3 (1969), pp. 143
[9.]
D.J. Stone, C. Zaldivar, Keltz.
The Effects of very low doses of nebulized isoproterenol, nebulized saline, and intravenous isoproterenol on blood in patiens with chronic bronchitis.
Am. Rev. Resp. Dis., 101 (1970), pp. 511
[10.]
American Thoracic Society.
Chronic Bronchitis Asthma and Pulmonary Emphisema. A statement by the commitee on diagnostic Standars for nontuberculous respiratory disease.
Am. Rev. Resp. Dis., 85 (1962), pp. 762
[11.]
G. Zaid, G.N. Beall.
Bronchia! response to β-adrenergic blocage.
New Engl. J. Med., 275 (1966), pp. 580
[12.]
R. Marcelle, R. Bottin, J. Jachmes, J. Lecompte.
Reaction bronchomotrices de Thomme sain apres clocage des recepteurs β-adrenergiques.
Acta Altera., 23 (1968), pp. 11
[13.]
P. Turner, J. Burman.
A comparison of the effects of propranolol and practolol on forced expiratory volume and resting heart rate in normal subjects.
Arch. Int. Pharmacodyn., 191 (1971), pp. 104
[14.]
L. Nordstrom, F. Mac.Donald, F. Gobel.
Effects of propranolol on respiratory function and exercise tolerance in patients with chronic lung disease.
Chest, 76 (1975), pp. 287
Copyright © 1976. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?