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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Diffuse interstitial lung diseases &#40;DILD&#41; form a group of diseases which affect the alveolar interstitial space and share very similar clinical&#44; radiological&#44; and functional features&#44; making lung biopsy essential for establishing diagnosis&#44; prognosis&#44; and treatment in many cases&#46; We aimed to see whether there was agreement in histopathological diagnosis among different groups of pathologists in their assessment of these diseases&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Biopsies were studied from 33 patients suffering from noninfectious&#44; nontumorous DILD&#46; The biopsies had been assessed by 2 groups of pathologists&#58; one specializing in this type of disease and another which was not a specialist group&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">There was disagreement in the histology reports of 10 out of the 33 cases studied &#40;30&#46;3&#37;&#41;&#58; 9 cases in the group of 22 cases of idiopathic interstitial pneumonia &#40;40&#46;9&#37;&#41; and 1 in the group of 3 DILD with known or associated causes&#46; No discrepancies were found&#44; however&#44; in the diagnosis of primary DILD or DILD associated with other&#44; less well-defined processes&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">We believe that idiopathic interstitial pneumonias are the DILD which pose most problems for pathologists&#46; Therefore&#44; the study of DILD requires specific dedication by pathologists and other professionals and specialists&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Las enfermedades pulmonares intersticiales difusas &#40;EPID&#41; son un conjunto de enfermedades que afecta al espacio alveolointersticial&#44; con manifestaciones cl&#237;nicas&#44; radiol&#243;gicas y funcionales muy similares&#44; por lo que en muchos casos el estudio de la biopsia pulmonar ser&#225; fundamental para el diagn&#243;stico&#44; pron&#243;stico y tratamiento&#46; Hemos querido ver si hay o no concordancia histopatol&#243;gica diagn&#243;stica&#44; entre diferentes grupos de pat&#243;logos&#44; en la valoraci&#243;n de estas enfermedades&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se han estudiado las biopsias de 33 pacientes afectados de EPID no infecciosa ni tumoral&#44; las cuales han sido valoradas por 2 grupos de pat&#243;logos&#58; uno con especial inter&#233;s por este tipo de enfermedades&#44; y otro grupo no dedicado especialmente a esta enfermedad&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Al confrontar posteriormente los resultados&#44; observamos en los informes histol&#243;gicos una discordancia en el diagn&#243;stico de 10 de los 33 casos estudiados &#40;30&#44;3&#37;&#41;&#44; 9 de ellos en el grupo de las 22 neumon&#237;as intersticiales idiop&#225;ticas &#40;40&#44;9&#37;&#41; y un caso en el grupo de las 3 EPID de causas conocidas o asociadas&#46; Sin embargo&#44; no encontramos ninguna discrepancia en el grupo de EPID primarias o asociadas a otros procesos no bien conocidos&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Creemos que las neumon&#237;as intersticiales idiop&#225;ticas son el grupo de EPID que m&#225;s problemas de diagn&#243;stico histol&#243;gico pueden plantear al pat&#243;logo&#46; Por tanto&#44; es fundamental una especial dedicaci&#243;n por parte de estos profesionales y de los distintos especialistas que est&#225;n relacionados con el estudio de las EPID&#46;</p>"
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                          "autores" => array:6 [
                            0 => "JL Bodineau"
                            1 => "L Izquierdo"
                            2 => "E Rodr&#237;guez"
                            3 => "J Mart&#237;n"
                            4 => "M Fajardo"
                            5 => "F Borderas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
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                        "volumen" => "39"
                        "paginaInicial" => "23"
                        "paginaFinal" => "28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12550016"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Osificaci&#243;n pulmonar difusa asociada a fibrosis pulmonar idiop&#225;tica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C Fern&#225;ndez"
                            1 => "O Quercia"
                            2 => "N Bustamante"
                            3 => "H Moreno"
                            4 => "A Uribe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
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                        "paginaInicial" => "595"
                        "paginaFinal" => "598"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15574274"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "What causes cryptogenic fibrosing alveolitis&#63; A case-control study of environmental exposure to dust"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J Scott"
                            1 => "I Johnston"
                            2 => "J Brintton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "1990"
                        "volumen" => "301"
                        "paginaInicial" => "1015"
                        "paginaFinal" => "1017"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2249047"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inter-observer variation between pathologists in diffuse parenchymal lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "AG Nicholson"
                            1 => "BJ Addis"
                            2 => "H Bharucha"
                            3 => "CA Clelland"
                            4 => "B Corrin"
                            5 => "AR Gibbs"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2004"
                        "volumen" => "59"
                        "paginaInicial" => "500"
                        "paginaFinal" => "505"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognostic implications of histologic patterns in multiple surgical lung biopsies from patients with idiopathic interstitial pneumonias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H Monaghan"
                            1 => "A Wells"
                            2 => "T Colby"
                            3 => "R du Bois"
                            4 => "D Hansell"
                            5 => "A Nicholson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2004"
                        "volumen" => "125"
                        "paginaInicial" => "522"
                        "paginaFinal" => "526"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14769733"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Histopathologic variability in usual and nonspecific interstitial pneumonias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K Flaherty"
                            1 => "W Travis"
                            2 => "T Colby"
                            3 => "G Toews"
                            4 => "E Kazerooni"
                            5 => "B Gross"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.164.9.2103074"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2001"
                        "volumen" => "164"
                        "paginaInicial" => "1722"
                        "paginaFinal" => "1727"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11719316"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nonspecific interstitial pneumonia&#58; nobody said it&#39;s perfect"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A Nicholson"
                            1 => "A Wells"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.164.9.2108099a"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2001"
                        "volumen" => "164"
                        "paginaInicial" => "1553"
                        "paginaFinal" => "1554"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11719289"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Idiopathic interstitial pneumonias and the concept of the trump card"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S Dani"
                            1 => "MD Zander"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
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                        "paginaInicial" => "359"
                        "paginaFinal" => "360"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14769707"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
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Vol. 41. Issue 10.
Pages 566-568 (October 2005)
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Vol. 41. Issue 10.
Pages 566-568 (October 2005)
Original Articles
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Variability Among Pathologists in the Histological Diagnosis of Diffuse Interstitial Lung Diseases
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J.M. Sánchez-Varillaa,
Corresponding author
sanchezva@terra.es

Correspondence: Dr. J.M. Sánchez-Varilla. Alejandro Collantes 26, P 2, 2.° B. 41005 Sevilla. España
, S. Recio-Gallardob, J.M. Benítez-Moyaa, V. Almadana-Pachecoa, J. Peña de Bustilloa, V. Martínez-Puentesa
a Servicio de Neumología, Hospital Universitario Virgen Macarena, Sevilla, Spain
b Servicio de Radiología, Hospital Universitario Virgen Macarena, Sevilla, Spain
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Abstract
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Objective

Diffuse interstitial lung diseases (DILD) form a group of diseases which affect the alveolar interstitial space and share very similar clinical, radiological, and functional features, making lung biopsy essential for establishing diagnosis, prognosis, and treatment in many cases. We aimed to see whether there was agreement in histopathological diagnosis among different groups of pathologists in their assessment of these diseases.

Material and methods

Biopsies were studied from 33 patients suffering from noninfectious, nontumorous DILD. The biopsies had been assessed by 2 groups of pathologists: one specializing in this type of disease and another which was not a specialist group.

Results

There was disagreement in the histology reports of 10 out of the 33 cases studied (30.3%): 9 cases in the group of 22 cases of idiopathic interstitial pneumonia (40.9%) and 1 in the group of 3 DILD with known or associated causes. No discrepancies were found, however, in the diagnosis of primary DILD or DILD associated with other, less well-defined processes.

Conclusions

We believe that idiopathic interstitial pneumonias are the DILD which pose most problems for pathologists. Therefore, the study of DILD requires specific dedication by pathologists and other professionals and specialists.

Key Words:
Diffuse idiopathic interstitial pneumonia
Variability
Histology
Agreement
Objetivo

Las enfermedades pulmonares intersticiales difusas (EPID) son un conjunto de enfermedades que afecta al espacio alveolointersticial, con manifestaciones clínicas, radiológicas y funcionales muy similares, por lo que en muchos casos el estudio de la biopsia pulmonar será fundamental para el diagnóstico, pronóstico y tratamiento. Hemos querido ver si hay o no concordancia histopatológica diagnóstica, entre diferentes grupos de patólogos, en la valoración de estas enfermedades.

Material y métodos

Se han estudiado las biopsias de 33 pacientes afectados de EPID no infecciosa ni tumoral, las cuales han sido valoradas por 2 grupos de patólogos: uno con especial interés por este tipo de enfermedades, y otro grupo no dedicado especialmente a esta enfermedad.

Resultados

Al confrontar posteriormente los resultados, observamos en los informes histológicos una discordancia en el diagnóstico de 10 de los 33 casos estudiados (30,3%), 9 de ellos en el grupo de las 22 neumonías intersticiales idiopáticas (40,9%) y un caso en el grupo de las 3 EPID de causas conocidas o asociadas. Sin embargo, no encontramos ninguna discrepancia en el grupo de EPID primarias o asociadas a otros procesos no bien conocidos.

Conclusiones

Creemos que las neumonías intersticiales idiopáticas son el grupo de EPID que más problemas de diagnóstico histológico pueden plantear al patólogo. Por tanto, es fundamental una especial dedicación por parte de estos profesionales y de los distintos especialistas que están relacionados con el estudio de las EPID.

Palabras clave:
Neumonía intersticial difusa idiopática
Variabilidad
Histología
Discordancia
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REFERENCES
[1]
A Xaubet, J Ancochea, R Blanquer, C Montero, F Morell, E Rodríguez Becerra, Grupo de Investigación en Enfermedades Pulmonares Intersticiales Difusas, et al.
Área de Técnicas y Trasplante. SEPAR. Diagnóstico y tratamiento de las enfermedades pulmonares intersticiales difusas.
Arch Bronconeumol, 39 (2003), pp. 580-600
[2]
AG Nicholson, IJ Perry, PM Cury, P Jackson, CM McComick, B Corrin, et al.
Reproducibility of the WHO/IASIC grading system for pre-invasive squamous lesions of the bronchus: a study of inter-observer and intra-observer variation.
Histopathology, 38 (2001), pp. 202-208
[3]
American Thoracic Society/European Respiratory Society.
International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias.
Am J Respir Crit Care Med, 165 (2002), pp. 277-304
[4]
AA Liebow, CB Carrington.
The interstitial pneumonias.
Frontiers of pulmonary radiology, 1st ed., pp. 102-141
[5]
ALA Katzenstein.
Katzenstein and Askin's surgical pathology of nonneoplastic lung disease, W.B. Saunder, (1997),
[6]
NL Müller, TV Colby.
Idiopathic interstitial pneumonias: high-resolution CT and histologic findings.
Radiographics, 17 (1997), pp. 1016-1022
[7]
TE King, U Costabel, JF Cordier, G Dopico, R du Bois, D Lynch, et al.
Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement.
Am J Respir Crit Care Med, 161 (2000), pp. 646-664
[8]
JL Bodineau, L Izquierdo, E Rodríguez, J Martín, M Fajardo, F Borderas, et al.
Evaluación de los criterios diagnósticos clínicos de fibrosis pulmonar.
Arch Bronconeumol, 39 (2003), pp. 23-28
[9]
C Fernández, O Quercia, N Bustamante, H Moreno, A Uribe.
Osificación pulmonar difusa asociada a fibrosis pulmonar idiopática.
Arch Bronconeumol, 40 (2004), pp. 595-598
[10]
J Scott, I Johnston, J Brintton.
What causes cryptogenic fibrosing alveolitis? A case-control study of environmental exposure to dust.
BMJ, 301 (1990), pp. 1015-1017
[11]
AG Nicholson, BJ Addis, H Bharucha, CA Clelland, B Corrin, AR Gibbs, et al.
Inter-observer variation between pathologists in diffuse parenchymal lung disease.
Thorax, 59 (2004), pp. 500-505
[12]
H Monaghan, A Wells, T Colby, R du Bois, D Hansell, A Nicholson.
Prognostic implications of histologic patterns in multiple surgical lung biopsies from patients with idiopathic interstitial pneumonias.
Chest, 125 (2004), pp. 522-526
[13]
K Flaherty, W Travis, T Colby, G Toews, E Kazerooni, B Gross, et al.
Histopathologic variability in usual and nonspecific interstitial pneumonias.
Am J Respir Crit Care Med, 164 (2001), pp. 1722-1727
[14]
A Nicholson, A Wells.
Nonspecific interstitial pneumonia: nobody said it's perfect.
Am J Respir Crit Care Med, 164 (2001), pp. 1553-1554
[15]
S Dani, MD Zander.
Idiopathic interstitial pneumonias and the concept of the trump card.
Chest, 125 (2004), pp. 359-360
Copyright © 2005. Sociedad Española de Neumología y Cirugía Torácica (SEPAR)
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