array:23 [ "pii" => "S030028962300306X" "issn" => "03002896" "doi" => "10.1016/j.arbres.2023.09.010" "estado" => "S300" "fechaPublicacion" => "2024-01-01" "aid" => "3406" "copyright" => "SEPAR" "copyrightAnyo" => "2023" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2024;60:44-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:18 [ "pii" => "S0300289623003125" "issn" => "03002896" "doi" => "10.1016/j.arbres.2023.09.015" "estado" => "S300" "fechaPublicacion" => "2024-01-01" "aid" => "3412" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2024;60:46-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Placental Transmogrification of the Lung Associated With Pulmonary Carcinoma: Unusual Presentation of a Pulmonary Nodule" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "46" "paginaFinal" => "47" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2374 "Ancho" => 2007 "Tamanyo" => 777215 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) 11<span class="elsevierStyleHsp" style=""></span>mm solid nodule in RUL. (B) 7<span class="elsevierStyleHsp" style=""></span>mm subsolid nodule in middle lobe. (C) Hypermetabolic uptake in RUL with a maximum standardized uptake value (SUV) of 10.38. (D) TPL (E) Low-power magnification of placental transfmogrification showing villi-like proliferation destroying normal lung architecture, Hematoxylin-Eosin [ HE] x4. (F and G) Intermediate and high-power magnification showing papillary structures resembling placental villi, lined by cuboidal epithelial cells and containing myxoid-edematous or fibrotic stroma, with a variable number of bland stromal cells, proliferating vessels and inflammatory cells; HEX20.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Stephany Ivonne Briones Alvarado, Tinixara Hernández Hernández, José Javier García López, María García Martos, Paola Benedetti" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Stephany Ivonne" "apellidos" => "Briones Alvarado" ] 1 => array:2 [ "nombre" => "Tinixara" "apellidos" => "Hernández Hernández" ] 2 => array:2 [ "nombre" => "José Javier" "apellidos" => "García López" ] 3 => array:2 [ "nombre" => "María" "apellidos" => "García Martos" ] 4 => array:2 [ "nombre" => "Paola" "apellidos" => "Benedetti" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289623003125?idApp=UINPBA00003Z" "url" => "/03002896/0000006000000001/v3_202406051404/S0300289623003125/v3_202406051404/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0300289623003617" "issn" => "03002896" "doi" => "10.1016/j.arbres.2023.10.009" "estado" => "S300" "fechaPublicacion" => "2024-01-01" "aid" => "3424" "copyright" => "SEPAR" "documento" => "article" "crossmark" => 1 "subdocumento" => "rev" "cita" => "Arch Bronconeumol. 2024;60:33-43" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review Article</span>" "titulo" => "Ultrasound in the Study of Thoracic Diseases: Innovative Aspects" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "33" "paginaFinal" => "43" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0035" "etiqueta" => "Fig. 7" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "fuente" => "Modified from Wang L et al. Ann Thorac Surg. 2015;100(4):12031210." "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr7.jpeg" "Alto" => 1952 "Ancho" => 2925 "Tamanyo" => 385043 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Ultrasonographic features during EBUS used to differentiate metastatic adenopathies from those of reactive origin: size, axis (long axis/short axis), shape (oval/round), margin (clear/not clear), central hilar structure (present/absent), echogenicity (homogeneous/heterogeneous), necrosis (present/absent), conglomeration (present/absent), calcification (present or absent), vascular pattern (avascular/hilar/non-hilar/capsular/centrally, mixed). Rounded shape, absence of central hilar structure, presence of conglomerate and non-hilar vascular perfusion pattern may predict lymph node metastasis.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Beatriz Romero Romero, Iván Vollmer Torrubiano, Jose Martín Juan, Sarah Heili Frades, Javier Pérez Pallares, Virginia Pajares Ruiz, Aurelio Wangüemert Pérez, Hernández Cristina Ramos, Enrique Cases Viedma" "autores" => array:9 [ 0 => array:2 [ "nombre" => "Beatriz" "apellidos" => "Romero Romero" ] 1 => array:2 [ "nombre" => "Iván" "apellidos" => "Vollmer Torrubiano" ] 2 => array:2 [ "nombre" => "Jose" "apellidos" => "Martín Juan" ] 3 => array:2 [ "nombre" => "Sarah" "apellidos" => "Heili Frades" ] 4 => array:2 [ "nombre" => "Javier" "apellidos" => "Pérez Pallares" ] 5 => array:2 [ "nombre" => "Virginia" "apellidos" => "Pajares Ruiz" ] 6 => array:2 [ "nombre" => "Aurelio" "apellidos" => "Wangüemert Pérez" ] 7 => array:2 [ "nombre" => "Hernández" "apellidos" => "Cristina Ramos" ] 8 => array:2 [ "nombre" => "Enrique" "apellidos" => "Cases Viedma" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289623003617?idApp=UINPBA00003Z" "url" => "/03002896/0000006000000001/v3_202406051404/S0300289623003617/v3_202406051404/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Unusual Case of IgG4-Related Disease Tracheal Stenosis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "44" "paginaFinal" => "45" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "F.R. Oliveri Aruete, C. Almonacid Sanchez, U. Caballero Silva" "autores" => array:3 [ 0 => array:4 [ "nombre" => "F.R." "apellidos" => "Oliveri Aruete" "email" => array:1 [ 0 => "Filomena.oliveri@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "C." "apellidos" => "Almonacid Sanchez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "U." "apellidos" => "Caballero Silva" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Hospital Universitario de Toledo, Toledo, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Hospital Universitario Ramón y Cajal, Madrid, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2002 "Ancho" => 3008 "Tamanyo" => 498175 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Morphology of the spirometric curve with inspiratory and expiratory plateau. (B) Distal tracheal stenosis seen in fibrobronchoscopy. (C and D) Chest CT with lobulated soft tissue mass, at the level of the distal third of the tracheal lumen, which conditions partial stenosis. (E) Mediastinal lesion with pathologic metabolism. (F) Chest CT reconstruction showing tracheal stenosis.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">28-Year-old woman originally from Peru. History of pneumonia at the age of 2. Seen in the Pulmonology clinic for grade 1 mMRC dyspnea and dry cough with cold foods. Presented to the emergency department with increased dyspnea, non-productive cough, fever, epistaxis, dysphagia, and odynophagia. Physical examination revealed stridor following a SARS-CoV-2 infection in 2020, with no history of intubation. Forced spirometry (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1A</a>) showed a spirometry curve morphology with inspiratory and expiratory plateaus suggestive of tracheal obstruction. Bronchoscopy (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1B</a>) revealed distal tracheal stenosis, measuring 2–3<span class="elsevierStyleHsp" style=""></span>cm, with tissue originating from the right lateral wall, occupying 90% of the tracheal lumen and protruding over the entrance of the right main bronchus. IgG 922<span class="elsevierStyleHsp" style=""></span>mg/dL, IgE 71.4<span class="elsevierStyleHsp" style=""></span>mg/dL. Chest CT scan (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1C, D, and F</a>) showed a lobulated soft tissue mass in the distal third of the tracheal lumen, encroaching and partially obstructing its anterior and right borders, and to a lesser extent, the left side, carina, and right main bronchus. It measures approximately 28<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>28<span class="elsevierStyleHsp" style=""></span>mm. PET-CT (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1E</a>) revealed a mediastinal lesion with pathological metabolism (SUVmax 7) warranting histological evaluation. No other local or distant abnormalities were noted.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Diagnosis via rigid bronchoscopy: Tracheal mucosa biopsy revealed intensely artifacted sclerosing inflammatory lesion with highly suggestive histological characteristics of IgG4-associated disease. Treated with a Y-shaped endobronchial tracheal prosthesis (Dumon type) due to critical tracheal stenosis, along with prednisone at 1<span class="elsevierStyleHsp" style=""></span>mg/kg with gradual tapering, resulting in a reduction in the size of the peritracheal soft tissue lesion. The prosthesis was removed after 5 months.</p><p id="par0015" class="elsevierStylePara elsevierViewall">IgG4-RD is a systemic condition characterized by abundant infiltration of IgG4-positive plasma cells. Approximately 90% of patients exhibit systemic involvement, with isolated organ lesions, nodules, or masses being rare. Laryngotracheal involvement is exceptionally rare, described in only a limited number of cases.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Elevated serum IgG4 concentration is not necessary for diagnosis, as it can also be elevated in other conditions, and roughly 30% of patients with biopsy-confirmed IgG4-RD have normal serum concentrations, highlighting the importance of histopathology.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Most IgG4-RD patients respond favorably to treatment with glucocorticoids, and the effectiveness of the anti-CD20 monoclonal antibody rituximab has been described in cases of hypopharyngolaryngeal involvement, especially in cases refractory to systemic corticosteroids.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Subglottic involvement is a rare manifestation of IgG4-RD with rapid progression to critical obstruction, underscoring the importance of recognizing and treating airway stenoses in patients refractory to local treatments.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors’ contributions</span><p id="par0035" class="elsevierStylePara elsevierViewall">All authors were involved in the conception and design of the work; acquisition, analysis, interpretation of data, drafting the work, revising it critically for important intellectual content.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interests</span><p id="par0040" class="elsevierStylePara elsevierViewall">CAS has received fees in the last 3 years for giving lectures, scientific advice, participation in clinical studies, or writing publications for (in alphabetical order): ALK, AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Novartis, and Pfizer. CAS declares not receiving ever, directly or indirectly, funding from the tobacco industry or its affiliates. FROA and UCS has no conflict of interests and declare not receiving ever, directly or indirectly, funding from the tobacco industry or its affiliates.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Authors’ contributions" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflict of interests" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2002 "Ancho" => 3008 "Tamanyo" => 498175 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Morphology of the spirometric curve with inspiratory and expiratory plateau. (B) Distal tracheal stenosis seen in fibrobronchoscopy. (C and D) Chest CT with lobulated soft tissue mass, at the level of the distal third of the tracheal lumen, which conditions partial stenosis. (E) Mediastinal lesion with pathologic metabolism. (F) Chest CT reconstruction showing tracheal stenosis.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0020" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characterizing IgG4-related disease with 18F-FDG PET/CT: a prospective cohort study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Zhang" 1 => "H. Chen" 2 => "Y. Ma" 3 => "Y. Xiao" 4 => "N. Niu" 5 => "W. Lin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00259-014-2729-3" "Revista" => array:7 [ "tituloSerie" => "Eur J Nucl Med Mol Imaging" "fecha" => "2014" "volumen" => "41" "paginaInicial" => "1624" "paginaFinal" => "1634" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24764034" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1052305719302265" "estado" => "S300" "issn" => "10523057" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0025" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recent advances in knowledge regarding the head and neck manifestations of IgG4-related disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Takano" 1 => "M. Yamamoto" 2 => "H. Takahashi" 3 => "T. Himi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.anl.2016.10.011" "Revista" => array:6 [ "tituloSerie" => "Auris Nasus Larynx" "fecha" => "2017" "volumen" => "44" "paginaInicial" => "7" "paginaFinal" => "17" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27956101" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0030" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical manifestations of IgG4-related disease in the pharynx: case series and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Reder" 1 => "E. Della-Torre" 2 => "J.H. Stone" 3 => "M. Mori" 4 => "P. Song" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/0003489414549574" "Revista" => array:6 [ "tituloSerie" => "Ann Otol Rhinol Laryngol" "fecha" => "2015" "volumen" => "124" "paginaInicial" => "173" "paginaFinal" => "178" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25204708" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03002896/0000006000000001/v3_202406051404/S030028962300306X/v3_202406051404/en/main.assets" "Apartado" => array:4 [ "identificador" => "93562" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Case Reports" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000006000000001/v3_202406051404/S030028962300306X/v3_202406051404/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028962300306X?idApp=UINPBA00003Z" ]
Journal Information
Vol. 60. Issue 1.
Pages 44-45 (January 2024)
Vol. 60. Issue 1.
Pages 44-45 (January 2024)
Case Report
Unusual Case of IgG4-Related Disease Tracheal Stenosis
Visits
459
This item has received
Article information
These are the options to access the full texts of the publication Archivos de Bronconeumología