Journal Information
Vol. 55. Issue 10.
Pages 532 (October 2019)
Clinical Image
Full text access
Tracheobronchial Amyloidosis as an Incidental Finding in a Patient With Lung Cancer
Amiloidosis traqueobronquial como hallazgo incidental en un paciente con neoplasia pulmonar
Blanca de Vega Sáncheza,
Corresponding author

Corresponding author.
, Carlos Disdier Vicentea,b, Gerardo Martínez Garcíac
a Unidad de Broncoscopias y Técnicas Pleurales, Servicio de Neumología, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
b Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Valladolid, Spain
c Servicio de Anatomía Patológica, Hospital Clínico Universitario Valladolid, Valladolid, Spain
Article information
Full Text
Download PDF
Figures (1)
Full Text

We report the case of a 67-year-old man, former smoker, referred for a flexible bronchoscopy (FB), in view of radiological findings indicative of lung cancer. A detailed study of the imaging tests showed the existence of a lung mass and increased density in both lateral walls of the middle third of the trachea and the main carina with no pathological uptake on PET, visible in the flexible bronchoscopy (Fig. 1). Given these findings and the appearance of the lesions on endoscopy, lung mass and tracheal samples were obtained to confirm the endoscopic suspicion of tracheobronchial amyloidosis vs neoplastic infiltration.

Fig. 1.

(A and B) Computed tomography and PET. (C and D) Raised erythematous hypervascular plaques in the right middle third of the trachea and main carina extending along the medial wall of the right main bronchus. (E and F) Presence of acidophilic deposits in the submucosa corresponding to amyloid substance after specific staining with Congo red and thioflavin T.


Histopathological studies established the diagnosis of localized primary tracheobronchial amyloidosis and surgically unresectable pulmonary adenocarcinoma (T2bN3M0). Tracheobronchial amyloidosis is a rare disease that, when detected on endoscopy, requires further studies to rule out secondary involvement.1 In the absence of a standardized treatment2 and the absence of tracheobronchial lumen compromise, chemotherapy was started. Endoscopic treatment was initially ruled out and the patient was followed up with endoscopic and clinical examinations. The presence of raised erythematous plaques in the tracheobronchial tree should prompt the endoscopist to consider this disease in the differential diagnosis.

J. Berraondo, L. Novella, F. Sanz, R. Lluch, E. de Casimiro, T. Lloret.
Manejo de la amiloidosis traqueobronquial mediante técnicas broncoscópicas terapéuticas.
Arch Bronconeumol, 49 (2013), pp. 207-209
V. Almadana, E. Luque, A.J. Wals, T. Montemayor.
External beam radiation therapy: a treatment modality in diffuse tracheobronchial amyloidosis.
Teodoro Montemayor Rubio Arch Bronconeumol, 51 (2015), pp. 602-610

Please cite this article as: de Vega Sánchez B, Disdier Vicente C, Martínez García G. Amiloidosis traqueobronquial como hallazgo incidental en un paciente con neoplasia pulmonar. Arch Bronconeumol. 2019;55:532.

Copyright © 2018. SEPAR
Archivos de Bronconeumología

Subscribe to our newsletter

Article options

Are you a health professional able to prescribe or dispense drugs?