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Vol. 30. Issue 9.
Pages 471-472 (November 1994)
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Vol. 30. Issue 9.
Pages 471-472 (November 1994)
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Toxicidad pulmonar aguda por carbamazepina: A propósito de un caso
Acute lung toxicity induced by carbamazepine. A case report
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R. Fernández Álvarez*, J.A. Gullón Blanco, C. Riesgo Alonso, L. Molinos Martín, J. Martínez González-Río
Servicio de Neumología. Hospital Central de Asturias. Hospital de Covadonga. Oviedo
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La presencia de toxicidad pulmonar por carbamazepina parece tratarse de un proceso no dependiente de la dosis, que cursa con infiltrados pulmonares, eosinofilia y exantema cutáneo. Comunicamos un caso de presentación aguda, con evolución favorable tras supresión del fármaco y tratamiento con corticoides. La práctica de un lavado broncoalveolar demostró una inversión del cociente linfocitario CD4/CD8, lo cual, sumado a otras experiencias comunicadas en la literatura, parece apoyar el diagnóstico de toxicidad pulmonar por fármacos.

Palabras clave:
Toxicidad pulmonar
Carbamazepina

Pulmonary toxicity caused by carbamazepine seems to be a non dose-dependent process involving pulmonary infiltrates, eosinofilia and skin rash. We report a case with acute presentation that resolved successfully after the drug was withdrawn and the patient was treated with corticosteroids. Bronchoalveolar lavage showed an inversion of the lymphocyte ratio CD4/CD8 supporting the suggestion by other authors that drug-induced pulmonary toxicity.

Key words:
Lung toxicity
Carbamazepine
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Bibliografía
[1.]
N. Takahashi, H. Aizawa, S. Takata, K. Matsumoto, H. Koto, H. Inoue, et al.
Acute interstitial pneumonitos induced by carbamazepine.
Eur Respir J, 6 (1993), pp. 1.409-1.411
[2.]
S.A. Cullinan, G.C. Bower.
Acute pulmonary hypersensitivity to carbamazepine.
Chest, 68 (1975), pp. 580-581
[3.]
W.C. Stephan, R.D. Parks, B. Tempest.
Acute hypersensitivity pneumonitis associated with carbamazepine therapy.
Chest, 74 (1978), pp. 463-464
[4.]
T. Lee, G.M. Cochrane, P. Amlot.
Pulmonary eosinophilia and asthma associated with carbamazepine.
Br Med J, 282 (1981), pp. 440
[5.]
G.W. Cannon.
Pulmonary complications of antirheumatic drug therapy.
Semin Arth Rheum, 6 (1990), pp. 353-364
[6.]
G.M. Akoun, J.L. Cadranel, B.J. Milleron, M.P. Flammang D’Orto, C.M. Mayaud.
Bronchoalveolar lavage cell data in 19 patients with drug-associated pneumonitis (except amiodarone).
Chest, 99 (1991), pp. 98-104
Copyright © 1994. Sociedad Española de Neumología y Cirugía Torácica
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