Toxicidad pulmonar aguda por carbamazepina: A propósito de un caso
Acute lung toxicity induced by carbamazepine. A case report
R. Fernández Álvarez*, J.A. Gullón Blanco, C. Riesgo Alonso, L. Molinos Martín, J. Martínez González-Río
Servicio de Neumología. Hospital Central de Asturias. Hospital de Covadonga. Oviedo
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"apellidos" => "Gullón Blanco" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Riesgo Alonso" ] 3 => array:2 [ "nombre" => "L." "apellidos" => "Molinos Martín" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Martínez González-Río" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Neumología. Hospital Central de Asturias. Hospital de Covadonga. Oviedo" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Joaquín Alonso Bonet, 6-8. 5.° izqda. 33206 Gijón. Asturias." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Acute lung toxicity induced by carbamazepine. A case report" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1994-02-22" "fechaAceptado" => "1994-03-13" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec569906" "palabras" => array:2 [ 0 => "Toxicidad pulmonar" 1 => "Carbamazepina" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec569907" "palabras" => array:2 [ 0 => "Lung toxicity" 1 => "Carbamazepine" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La presencia de toxicidad pulmonar por carbamazepina parece tratarse de un proceso no dependiente de la dosis, que cursa con infiltrados pulmonares, eosinofilia y exantema cutáneo. Comunicamos un caso de presentación aguda, con evolución favorable tras supresión del fármaco y tratamiento con corticoides. La práctica de un lavado broncoalveolar demostró una inversión del cociente linfocitario CD4/CD8, lo cual, sumado a otras experiencias comunicadas en la literatura, parece apoyar el diagnóstico de toxicidad pulmonar por fármacos.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Pulmonary toxicity caused by carbamazepine seems to be a non dose-dependent process involving pulmonary infiltrates, eosinofilia and skin rash. We report a case with acute presentation that resolved successfully after the drug was withdrawn and the patient was treated with corticosteroids. Bronchoalveolar lavage showed an inversion of the lymphocyte ratio CD4/CD8 supporting the suggestion by other authors that drug-induced pulmonary toxicity.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute interstitial pneumonitos induced by carbamazepine" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Takahashi" 1 => "H. Aizawa" 2 => "S. Takata" 3 => "K. Matsumoto" 4 => "H. Koto" 5 => "H. 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