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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To study lung function abnormalities and health-related quality of life &#40;HRQL&#41; in a group of patients diagnosed with generalized myasthenia gravis&#44; and to analyze the relationship between these 2 sets of variables&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">In a prospective study of 20 patients diagnosed with generalized myasthenia gravis&#44; the following parameters were measured&#58; spirometry&#44; static lung volumes&#44; breathing pattern&#44; maximal respiratory pressures&#44; and maximum voluntary ventilation&#46; HRQL was assessed using the 36-item short form general health questionnaire &#40;SF-36&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The mean &#40;SD&#41; age of the patients was 64 &#40;11&#41; years&#46; Patients were classified into 2 groups depending on whether they had IIa &#40;12 patients&#41; or IIb &#40;8 patients&#41; type disease&#46; A small decrease in total lung capacity &#40;86&#37;&#41; and slight reductions in maximal inspiratory pressure &#40;88&#37;&#41; and maximum voluntary ventilation &#40;63&#37; in group IIb&#41; were observed&#46; The HRQL domains most affected were those related to physical activity and self-perceived health status in all groups&#44; although women were more affected&#46; The scores relating to vitality and physical activity were found to be significantly associated with forced vital capacity and lung volumes&#46; Tidal volume was associated with maximal inspiratory and expiratory pressures&#44; inspiratory capacity&#44; and maximum voluntary ventilation&#46; The respiratory rate to tidal volume ratio was inversely associated with the first three of these variables&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">A very slight restrictive pattern and a reduction in inspiratory muscle strength were observed&#46; The HRQL domains most affected were those related to physical activity and the patients&#39; self-perceived health status&#46; The weakness of the respiratory muscles contributes to the abnormalities observed in lung function and to the deterioration of health-related quality of life&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Estudiar las alteraciones de la funci&#243;n pulmonar y de la calidad de vida relacionada con la salud &#40;CVRS&#41;&#44; as&#237; como las relaciones entre ambas &#225;reas&#44; en un grupo de pacientes diagnosticados de miastenia <span class="elsevierStyleItalic">gravis</span> generalizada&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio pros-pectivo en 20 pacientes diagnosticados de miastenia <span class="elsevierStyleItalic">gravis</span> generalizada&#46; Se evaluaron la espirometr&#237;a&#44; los vol&#250;menes pulmonares est&#225;ticos&#44; el patr&#243;n respiratorio&#44; las presiones respiratorias m&#225;ximas y la ventilaci&#243;n voluntaria m&#225;xima&#46; La CVRS se valor&#243; con el cuestionario general de salud SF-36&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La edad media &#40;&#177; desviaci&#243;n est&#225;ndar&#41; de los pacientes fue de 64 &#177; 11 a&#241;os&#46; Se clasificaron en IIa &#40;12 pacientes&#41; y IIb &#40;8 pacientes&#41;&#46; Se observaron una leve dismi-nuci&#243;n de la capacidad pulmonar total &#40;86&#37;&#41; y una ligera reducci&#243;n de la presi&#243;n inspiratoria m&#225;xima &#40;88&#37;&#41; y de la ventilaci&#243;n voluntaria m&#225;xima &#40;un 63&#37; en el grupo IIb&#41;&#46; Los dominios m&#225;s afectados de la CVRS fueron los relacio-nados con la actividad f&#237;sica y la percepci&#243;n general de la salud en todos los grupos&#44; pero con mayor intensidad en el sexo femenino&#46; Se observaron relaciones estad&#237;sticamente significativas entre las &#225;reas de vitalidad y actividad f&#237;sica&#44; la capacidad vital forzada y los vol&#250;menes pulmonares&#46; Tambi&#233;n se encontraron relaciones entre la presi&#243;n inspiratoria m&#225;xima&#44; la presi&#243;n espiratoria m&#225;xima&#44; la ventilaci&#243;n voluntaria m&#225;xima&#44; la capacidad inspiratoria con volumen circulante y el &#237;ndice volumen circulante&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Se observaron un patr&#243;n restrictivo muy ligero y reducci&#243;n de la fuerza muscular inspiratoria&#46; Los &#225;mbitos de la CVRS m&#225;s afectados fueron los relacionados con la actividad f&#237;sica y la percepci&#243;n general de la salud&#46; La afectaci&#243;n muscular respiratoria contribuye a una alteraci&#243;n en las variables de la funci&#243;n pulmonar y al deterioro de la calidad de vida relacionada con la salud&#46;</p>"
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Vol. 42. Issue 5.
Pages 218-224 (May 2006)
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Vol. 42. Issue 5.
Pages 218-224 (May 2006)
Original Articles
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The Relationship Between Lung Function and Health-Related Quality of Life in Patients With Generalized Myasthenia Gravis
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G.A. de Freitas Fregonezi*, V. Regiane-Resqueti, J. Pradas, L. Vigil, P. Casan
,**
Departament de Pneumologia, Hospital de la Santa Creu i Sant Pau, Facultat de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain
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Objective

To study lung function abnormalities and health-related quality of life (HRQL) in a group of patients diagnosed with generalized myasthenia gravis, and to analyze the relationship between these 2 sets of variables.

Patients and methods

In a prospective study of 20 patients diagnosed with generalized myasthenia gravis, the following parameters were measured: spirometry, static lung volumes, breathing pattern, maximal respiratory pressures, and maximum voluntary ventilation. HRQL was assessed using the 36-item short form general health questionnaire (SF-36).

Results

The mean (SD) age of the patients was 64 (11) years. Patients were classified into 2 groups depending on whether they had IIa (12 patients) or IIb (8 patients) type disease. A small decrease in total lung capacity (86%) and slight reductions in maximal inspiratory pressure (88%) and maximum voluntary ventilation (63% in group IIb) were observed. The HRQL domains most affected were those related to physical activity and self-perceived health status in all groups, although women were more affected. The scores relating to vitality and physical activity were found to be significantly associated with forced vital capacity and lung volumes. Tidal volume was associated with maximal inspiratory and expiratory pressures, inspiratory capacity, and maximum voluntary ventilation. The respiratory rate to tidal volume ratio was inversely associated with the first three of these variables.

Conclusions

A very slight restrictive pattern and a reduction in inspiratory muscle strength were observed. The HRQL domains most affected were those related to physical activity and the patients' self-perceived health status. The weakness of the respiratory muscles contributes to the abnormalities observed in lung function and to the deterioration of health-related quality of life.

Key words:
Lung function
Maximal respiratory pressures
Health-related quality of life (HRQL)
Myasthenia gravis
Objetivo

Estudiar las alteraciones de la función pulmonar y de la calidad de vida relacionada con la salud (CVRS), así como las relaciones entre ambas áreas, en un grupo de pacientes diagnosticados de miastenia gravis generalizada.

Pacientes y métodos

Se ha realizado un estudio pros-pectivo en 20 pacientes diagnosticados de miastenia gravis generalizada. Se evaluaron la espirometría, los volúmenes pulmonares estáticos, el patrón respiratorio, las presiones respiratorias máximas y la ventilación voluntaria máxima. La CVRS se valoró con el cuestionario general de salud SF-36.

Resultados

La edad media (± desviación estándar) de los pacientes fue de 64 ± 11 años. Se clasificaron en IIa (12 pacientes) y IIb (8 pacientes). Se observaron una leve dismi-nución de la capacidad pulmonar total (86%) y una ligera reducción de la presión inspiratoria máxima (88%) y de la ventilación voluntaria máxima (un 63% en el grupo IIb). Los dominios más afectados de la CVRS fueron los relacio-nados con la actividad física y la percepción general de la salud en todos los grupos, pero con mayor intensidad en el sexo femenino. Se observaron relaciones estadísticamente significativas entre las áreas de vitalidad y actividad física, la capacidad vital forzada y los volúmenes pulmonares. También se encontraron relaciones entre la presión inspiratoria máxima, la presión espiratoria máxima, la ventilación voluntaria máxima, la capacidad inspiratoria con volumen circulante y el índice volumen circulante.

Conclusiones

Se observaron un patrón restrictivo muy ligero y reducción de la fuerza muscular inspiratoria. Los ámbitos de la CVRS más afectados fueron los relacionados con la actividad física y la percepción general de la salud. La afectación muscular respiratoria contribuye a una alteración en las variables de la función pulmonar y al deterioro de la calidad de vida relacionada con la salud.

Palabras clave:
Función pulmonary
Presiones respiratorias máximas
Calidad de vida relacionada con la salud (CVRS)
Miastenia gravis
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Doctoral scholarship CNpq, Brazil (file number: 200005/01–4).

RedRespira, SEPAR-Instituto de Salud Carlos III, Spain. The preliminary results of this study were presented at the European Respiratory Society Annual Congress held in Glasgow, Scotland September 4–8, 2004

Copyright © 2006. Sociedad Española de Neumología y Cirugía Torácica (SEPAR)
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