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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">TO determine the prognostic factors for the survival in a group of patients operated on for a non-small cell lung cancer classified as T2N1M0&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">TWO hundred sixteen patients treated exclusively with surgery were studied&#46; Kaplan-Meier survival and Cox multivariable regression analyses were used&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The overall survival rate was 39&#46;8&#37; at 5 years and 29&#46;9&#37; at 10 years&#46; Sex&#44; age&#44; presence or absence of symptoms&#44; type of resection&#44; and number and location of affected lymph nodes had no effect on survival&#46; Tumor size &#40;<span class="elsevierStyleItalic">P</span> &#61; &#46;04&#41; and histologic type &#40;<span class="elsevierStyleItalic">P</span> &#61; &#46;03&#41; did significantly affect prognosis&#46; Both variables entered into the Cox multivariable regression model&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Patients operated on for non-small cell lung cancer classified as T2N1M0 have an overall probability of 5-year survival of approximately 40&#37;&#46; However&#44; the prognosis for this group of patients is heterogeneous&#58; in our study it was affected by the histologic type &#40;45&#46;5&#37; for squamous cell and 25&#37; for non-squamous cell cancers&#41; and tumor size &#40;53&#37; for tumors with a diameter of &#8804;3 cm&#44; 45&#37; for tumors between 3&#46;1 and 5 cm&#44; and 29&#37; for a tumor diameter &#62;5 cm&#41;&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Determinar los factores pron&#243;sticos de supervi-vencia de un grupo de pacientes operados de un carcinoma broncog&#233;nico no anapl&#225;sico de c&#233;lulas peque&#241;as y clasifica-dos como T2N1M0&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudi&#243; a 216 pacientes tratados exclusivamente con cirug&#237;a&#46; La supervivencia se analiz&#243; con el m&#233;todo de Kaplan-Meier y se utiliz&#243; el modelo de Cox para el an&#225;lisis multivariante&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La supervivencia global fue del 39&#44;8&#37; a los 5 a&#241;os y del 29&#44;9&#37; a los 10 a&#241;os&#46; El sexo&#44; la edad&#44; la presen-cia o ausencia de s&#237;ntomas&#44; la amplitud de la ex&#233;resis&#44; el n&#250;-mero de ganglios afectados y su localizaci&#243;n no influyeron en la supervivencia&#46; El tama&#241;o tumoral &#40;p &#61; 0&#44;04&#41; y la estir-pe histol&#243;gica &#40;p &#61; 0&#44;03&#41; s&#237; condicionaron significativamente el pron&#243;stico&#46; Ambas variables entraron en regresi&#243;n cuan-do se utiliz&#243; el an&#225;lisis multivariante&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los pacientes operados de un carcinoma broncog&#233;nico no anapl&#225;sico de c&#233;lulas peque&#241;as clasificado como T2N1M0 tienen una probabilidad de supervivencia global a los 5 a&#241;os en torno al 40&#37;&#46; Sin embargo&#44; no es un grupo de pacientes con un pron&#243;stico homog&#233;neo&#44; ya que en nuestro estudio estuvo condicionado por la estirpe histol&#243;gica &#40;un 45&#44;5&#37; para los epidermoides y un 25&#37; para los no epidermoides&#41; y el tama&#241;o tumoral &#40;un 53&#37; en los tumores con un di&#225;metro &#8804; 3 cm&#44; un 45&#37; entre 3&#44;1-5 cm y un 29&#37; en &#62; 5 cm&#41;&#46;</p>"
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Vol. 41. Issue 8.
Pages 430-433 (August 2005)
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Vol. 41. Issue 8.
Pages 430-433 (August 2005)
Original Articles
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T2N1M0 Non-Small Cell Lung Cancer: Surgery and Prognostic Factors
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J. Padilla
Corresponding author
jpadilla@comv.es

Correspondence: Dr. J. Padilla. Servicio de Cirugía Torácica. Hospital Universitario La Fe. Avda. de Campanar, 21. 46009 Valencia. España
, V. Calvo, J.C. Peñalver, C. Jordá, J. Escrivá, J. Cerón, A. García Zarza, J. Pastor, E. Blasco
Servicio de Cirugía Torácica, Hospital Universitario La Fe, Valencia, Spain
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Objective

TO determine the prognostic factors for the survival in a group of patients operated on for a non-small cell lung cancer classified as T2N1M0.

Patients and methods

TWO hundred sixteen patients treated exclusively with surgery were studied. Kaplan-Meier survival and Cox multivariable regression analyses were used.

Results

The overall survival rate was 39.8% at 5 years and 29.9% at 10 years. Sex, age, presence or absence of symptoms, type of resection, and number and location of affected lymph nodes had no effect on survival. Tumor size (P = .04) and histologic type (P = .03) did significantly affect prognosis. Both variables entered into the Cox multivariable regression model.

Conclusions

Patients operated on for non-small cell lung cancer classified as T2N1M0 have an overall probability of 5-year survival of approximately 40%. However, the prognosis for this group of patients is heterogeneous: in our study it was affected by the histologic type (45.5% for squamous cell and 25% for non-squamous cell cancers) and tumor size (53% for tumors with a diameter of ≤3 cm, 45% for tumors between 3.1 and 5 cm, and 29% for a tumor diameter >5 cm).

Key Words:
Carcinoma bronchogenic
Stage IIb
T2N1M0
Surgery
Prognosis
Objetivo

Determinar los factores pronósticos de supervi-vencia de un grupo de pacientes operados de un carcinoma broncogénico no anaplásico de células pequeñas y clasifica-dos como T2N1M0.

Pacientes y métodos

Se estudió a 216 pacientes tratados exclusivamente con cirugía. La supervivencia se analizó con el método de Kaplan-Meier y se utilizó el modelo de Cox para el análisis multivariante.

Resultados

La supervivencia global fue del 39,8% a los 5 años y del 29,9% a los 10 años. El sexo, la edad, la presen-cia o ausencia de síntomas, la amplitud de la exéresis, el nú-mero de ganglios afectados y su localización no influyeron en la supervivencia. El tamaño tumoral (p = 0,04) y la estir-pe histológica (p = 0,03) sí condicionaron significativamente el pronóstico. Ambas variables entraron en regresión cuan-do se utilizó el análisis multivariante.

Conclusiones

Los pacientes operados de un carcinoma broncogénico no anaplásico de células pequeñas clasificado como T2N1M0 tienen una probabilidad de supervivencia global a los 5 años en torno al 40%. Sin embargo, no es un grupo de pacientes con un pronóstico homogéneo, ya que en nuestro estudio estuvo condicionado por la estirpe histológica (un 45,5% para los epidermoides y un 25% para los no epidermoides) y el tamaño tumoral (un 53% en los tumores con un diámetro ≤ 3 cm, un 45% entre 3,1-5 cm y un 29% en > 5 cm).

Palabras clave:
Carcinoma broncogénico
Estadio IIb
T2N1M0
Cirugía
Factores pronósticos
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Copyright © 2005. Sociedad Española de Neumología y Cirugía Torácica (SEPAR)
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