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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">TO determine the prognostic factors for the survival in a group of patients operated on for a non-small cell lung cancer classified as T2N1M0&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">TWO hundred sixteen patients treated exclusively with surgery were studied&#46; Kaplan-Meier survival and Cox multivariable regression analyses were used&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The overall survival rate was 39&#46;8&#37; at 5 years and 29&#46;9&#37; at 10 years&#46; Sex&#44; age&#44; presence or absence of symptoms&#44; type of resection&#44; and number and location of affected lymph nodes had no effect on survival&#46; Tumor size &#40;<span class="elsevierStyleItalic">P</span> &#61; &#46;04&#41; and histologic type &#40;<span class="elsevierStyleItalic">P</span> &#61; &#46;03&#41; did significantly affect prognosis&#46; Both variables entered into the Cox multivariable regression model&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Patients operated on for non-small cell lung cancer classified as T2N1M0 have an overall probability of 5-year survival of approximately 40&#37;&#46; However&#44; the prognosis for this group of patients is heterogeneous&#58; in our study it was affected by the histologic type &#40;45&#46;5&#37; for squamous cell and 25&#37; for non-squamous cell cancers&#41; and tumor size &#40;53&#37; for tumors with a diameter of &#8804;3 cm&#44; 45&#37; for tumors between 3&#46;1 and 5 cm&#44; and 29&#37; for a tumor diameter &#62;5 cm&#41;&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Determinar los factores pron&#243;sticos de supervi-vencia de un grupo de pacientes operados de un carcinoma broncog&#233;nico no anapl&#225;sico de c&#233;lulas peque&#241;as y clasifica-dos como T2N1M0&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudi&#243; a 216 pacientes tratados exclusivamente con cirug&#237;a&#46; La supervivencia se analiz&#243; con el m&#233;todo de Kaplan-Meier y se utiliz&#243; el modelo de Cox para el an&#225;lisis multivariante&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La supervivencia global fue del 39&#44;8&#37; a los 5 a&#241;os y del 29&#44;9&#37; a los 10 a&#241;os&#46; El sexo&#44; la edad&#44; la presen-cia o ausencia de s&#237;ntomas&#44; la amplitud de la ex&#233;resis&#44; el n&#250;-mero de ganglios afectados y su localizaci&#243;n no influyeron en la supervivencia&#46; El tama&#241;o tumoral &#40;p &#61; 0&#44;04&#41; y la estir-pe histol&#243;gica &#40;p &#61; 0&#44;03&#41; s&#237; condicionaron significativamente el pron&#243;stico&#46; Ambas variables entraron en regresi&#243;n cuan-do se utiliz&#243; el an&#225;lisis multivariante&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los pacientes operados de un carcinoma broncog&#233;nico no anapl&#225;sico de c&#233;lulas peque&#241;as clasificado como T2N1M0 tienen una probabilidad de supervivencia global a los 5 a&#241;os en torno al 40&#37;&#46; Sin embargo&#44; no es un grupo de pacientes con un pron&#243;stico homog&#233;neo&#44; ya que en nuestro estudio estuvo condicionado por la estirpe histol&#243;gica &#40;un 45&#44;5&#37; para los epidermoides y un 25&#37; para los no epidermoides&#41; y el tama&#241;o tumoral &#40;un 53&#37; en los tumores con un di&#225;metro &#8804; 3 cm&#44; un 45&#37; entre 3&#44;1-5 cm y un 29&#37; en &#62; 5 cm&#41;&#46;</p>"
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Original Articles
T2N1M0 Non-Small Cell Lung Cancer: Surgery and Prognostic Factors
J. Padilla
Corresponding author
jpadilla@comv.es

Correspondence: Dr. J. Padilla. Servicio de Cirugía Torácica. Hospital Universitario La Fe. Avda. de Campanar, 21. 46009 Valencia. España
, V. Calvo, J.C. Peñalver, C. Jordá, J. Escrivá, J. Cerón, A. García Zarza, J. Pastor, E. Blasco
Servicio de Cirugía Torácica, Hospital Universitario La Fe, Valencia, Spain
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    "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
    "titulo" => "T2N1M0 Non-Small Cell Lung Cancer&#58; Surgery and Prognostic Factors"
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        "autoresLista" => "J&#46; Padilla, V&#46; Calvo, J&#46;C&#46; Pe&#241;alver, C&#46; Jord&#225;, J&#46; Escriv&#225;, J&#46; Cer&#243;n, A&#46; Garc&#237;a Zarza, J&#46; Pastor, E&#46; Blasco"
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    "fechaRecibido" => "2004-08-24"
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          "titulo" => "Key Words"
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            0 => "Carcinoma bronchogenic"
            1 => "Stage IIb"
            2 => "T2N1M0"
            3 => "Surgery"
            4 => "Prognosis"
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            0 => "Carcinoma broncog&#233;nico"
            1 => "Estadio IIb"
            2 => "T2N1M0"
            3 => "Cirug&#237;a"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">TO determine the prognostic factors for the survival in a group of patients operated on for a non-small cell lung cancer classified as T2N1M0&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">TWO hundred sixteen patients treated exclusively with surgery were studied&#46; Kaplan-Meier survival and Cox multivariable regression analyses were used&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The overall survival rate was 39&#46;8&#37; at 5 years and 29&#46;9&#37; at 10 years&#46; Sex&#44; age&#44; presence or absence of symptoms&#44; type of resection&#44; and number and location of affected lymph nodes had no effect on survival&#46; Tumor size &#40;<span class="elsevierStyleItalic">P</span> &#61; &#46;04&#41; and histologic type &#40;<span class="elsevierStyleItalic">P</span> &#61; &#46;03&#41; did significantly affect prognosis&#46; Both variables entered into the Cox multivariable regression model&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Patients operated on for non-small cell lung cancer classified as T2N1M0 have an overall probability of 5-year survival of approximately 40&#37;&#46; However&#44; the prognosis for this group of patients is heterogeneous&#58; in our study it was affected by the histologic type &#40;45&#46;5&#37; for squamous cell and 25&#37; for non-squamous cell cancers&#41; and tumor size &#40;53&#37; for tumors with a diameter of &#8804;3 cm&#44; 45&#37; for tumors between 3&#46;1 and 5 cm&#44; and 29&#37; for a tumor diameter &#62;5 cm&#41;&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Determinar los factores pron&#243;sticos de supervi-vencia de un grupo de pacientes operados de un carcinoma broncog&#233;nico no anapl&#225;sico de c&#233;lulas peque&#241;as y clasifica-dos como T2N1M0&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudi&#243; a 216 pacientes tratados exclusivamente con cirug&#237;a&#46; La supervivencia se analiz&#243; con el m&#233;todo de Kaplan-Meier y se utiliz&#243; el modelo de Cox para el an&#225;lisis multivariante&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La supervivencia global fue del 39&#44;8&#37; a los 5 a&#241;os y del 29&#44;9&#37; a los 10 a&#241;os&#46; El sexo&#44; la edad&#44; la presen-cia o ausencia de s&#237;ntomas&#44; la amplitud de la ex&#233;resis&#44; el n&#250;-mero de ganglios afectados y su localizaci&#243;n no influyeron en la supervivencia&#46; El tama&#241;o tumoral &#40;p &#61; 0&#44;04&#41; y la estir-pe histol&#243;gica &#40;p &#61; 0&#44;03&#41; s&#237; condicionaron significativamente el pron&#243;stico&#46; Ambas variables entraron en regresi&#243;n cuan-do se utiliz&#243; el an&#225;lisis multivariante&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los pacientes operados de un carcinoma broncog&#233;nico no anapl&#225;sico de c&#233;lulas peque&#241;as clasificado como T2N1M0 tienen una probabilidad de supervivencia global a los 5 a&#241;os en torno al 40&#37;&#46; Sin embargo&#44; no es un grupo de pacientes con un pron&#243;stico homog&#233;neo&#44; ya que en nuestro estudio estuvo condicionado por la estirpe histol&#243;gica &#40;un 45&#44;5&#37; para los epidermoides y un 25&#37; para los no epidermoides&#41; y el tama&#241;o tumoral &#40;un 53&#37; en los tumores con un di&#225;metro &#8804; 3 cm&#44; un 45&#37; entre 3&#44;1-5 cm y un 29&#37; en &#62; 5 cm&#41;&#46;</p>"
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