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Vol. 41. Issue 2.
Pages 99-101 (February 2005)
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Vol. 41. Issue 2.
Pages 99-101 (February 2005)
Case Reports
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Small Cell Lung Cancer and Cancer-Associated Retinopathy
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C. Bidegaina,
Corresponding author
cbidegain@comg.es

Correspondence: C. Bidegain. Clínica Girona. Joan Maragall, 26. 17002 Girona. España
, J. Rigaltb, E. Ribotc, J. Dorcad, J. Vayredad
a Servicio de Cirugía Torácica, Clínica Girona, Girona, Spain
b Servicio de Oftalmología, Clínica Girona, Girona, Spain
c Servicio de Medicina Interna, Clínica Girona, Girona, Spain
d Servicio de Oncología, Clínica Girona, Girona, Spain
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We report the case of a patient who presented with cancer-associated retinopathy and small cell carcinoma of the lung, which was treated surgically because the initial diagnostic biopsy finding was squamous cell carcinoma. The patient then underwent chemotherapy and radiation therapy. We discuss the characteristics and pathogenesis of this paraneoplastic syndrome as well as its association with the lung tumor's aberrant production of a protein that competes with retinal recoverin at the photoreceptors of the retinal cone.

Key Words:
Cancer-associated retinopathy
Small cell lung cancer
Paraneoplastic syndromes

Se presenta el caso de un paciente afectado de una retinopatía asociada a cáncer, con un carcinoma microcítico de pulmón tratado quirúrgicamente, ya que la biopsia del diag-nóstico inicial fue positiva para carcinoma epidermoide, y luego con quimio y radioterapia. Se analizan las caracterís-ticas de este síndrome paraneoplásico, su mecanismo pato-génico y su asociación con la producción anómala de una proteína por el tumor pulmonar que compite con la recove-rina autóctona en los receptores de los conos retinianos.

Palabras clave:
Retinopatía asociada a cáncer
Carcinoma microcítico
Síndromes paraneoplásicos
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Copyright © 2005. Sociedad Española de Neumología y Cirugía Torácica (SEPAR)
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