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Vol. 41. Issue 2.
Pages 99-101 (February 2005)
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Vol. 41. Issue 2.
Pages 99-101 (February 2005)
Case Reports
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Small Cell Lung Cancer and Cancer-Associated Retinopathy
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4865
C. Bidegaina,
Corresponding author
cbidegain@comg.es

Correspondence: C. Bidegain. Clínica Girona. Joan Maragall, 26. 17002 Girona. España
, J. Rigaltb, E. Ribotc, J. Dorcad, J. Vayredad
a Servicio de Cirugía Torácica, Clínica Girona, Girona, Spain
b Servicio de Oftalmología, Clínica Girona, Girona, Spain
c Servicio de Medicina Interna, Clínica Girona, Girona, Spain
d Servicio de Oncología, Clínica Girona, Girona, Spain
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We report the case of a patient who presented with cancer-associated retinopathy and small cell carcinoma of the lung, which was treated surgically because the initial diagnostic biopsy finding was squamous cell carcinoma. The patient then underwent chemotherapy and radiation therapy. We discuss the characteristics and pathogenesis of this paraneoplastic syndrome as well as its association with the lung tumor's aberrant production of a protein that competes with retinal recoverin at the photoreceptors of the retinal cone.

Key Words:
Cancer-associated retinopathy
Small cell lung cancer
Paraneoplastic syndromes

Se presenta el caso de un paciente afectado de una retinopatía asociada a cáncer, con un carcinoma microcítico de pulmón tratado quirúrgicamente, ya que la biopsia del diag-nóstico inicial fue positiva para carcinoma epidermoide, y luego con quimio y radioterapia. Se analizan las caracterís-ticas de este síndrome paraneoplásico, su mecanismo pato-génico y su asociación con la producción anómala de una proteína por el tumor pulmonar que compite con la recove-rina autóctona en los receptores de los conos retinianos.

Palabras clave:
Retinopatía asociada a cáncer
Carcinoma microcítico
Síndromes paraneoplásicos
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REFERENCES
[1]
M Thomson.
Síndromes paraneoplásicos neurológicos.
Harrison's principles of internal medicine, 14th ed., pp. 708-710
[2]
FG Holz, C Bellman, H Steffen, B Nolle, J Huober, H Krastel, et al.
Carcinoma associated retinopathy in breast carcinoma and carcinoid tumor.
Ophthalmology, 94 (1997), pp. 337-342
[3]
J Huober, FG Holz, H Schmid, B Nolle, C Bellman, H Krastel, et al.
Paraneoplastic retinopathy in 2 patients with breast carcinoma.
Zentralbl Gynakol., 119 (1997), pp. 278-281
[4]
CE Thirkill, AM Roth, JL Keltner.
Cancer-associated retinopathy.
Arch Ophthalmol., 105 (1987), pp. 372-375
[5]
CE Thirkill, RC Tait, NK Tyler, AM Roth, JL Keltner.
The cancer-associated retinopathy antigen is a recoverin-like protein.
Invest Ophthalmol Vis Sci., 33 (1992), pp. 2768-2772
[6]
JL Keltner, CE Thirkill, NK Tyler, AM Roth.
Management and monitoring of cancer-associated retinopathy.
Arch Ophthalmol., 110 (1992), pp. 48-53
[7]
AS Polans, MD Burton, TL Haley, JW Crabb, K Palczewski.
Recoverin, but not visinin is an autoantigen in the human retina identified with a cancer-associated retinopathy.
Inves Ophthalmol Vis Sci., 34 (1993), pp. 81-90
[8]
P De Potter.
Ocular manifestations of cancer.
Curr Opin Ophthalmol., 9 (1998), pp. 100-104
[9]
M Savchenko, A Bazhin, O Shifrina, S Demoura, E Kogan, A Chuchalin, et al.
Antirecoverin autoantibodies in the patient with non-small cell lung cancer but without cancer-associated retinopathy.
Lung Cancer, 41 (2003), pp. 363-367
[10]
H Ohguro, I Nakazawa.
Pathological roles of recoverin in cancer-associated retinopathy.
Ad Exp Med Biol., 514 (2002), pp. 109-124
[11]
A Maeda, H Ohguro, T Maeda, I Wada, N Sato, Y Kuroki, et al.
Aberrant expression of photoreceptor-specific calcium-binding protein recoverin in cancer cell lines.
Cancer Res., 60 (2000), pp. 1914-1920
[12]
G Adamus, J Guy, Jl Schid, A Arendt, PA Hargrave.
Role of antirecoverin autoantibodies in cancer-associated retinopathy.
Invest Ophthalmol Vis Sci., 34 (1993), pp. 2626-2633
[13]
SE Permyakov, AM Cherskaya, LA Wasserman, TI Khokhlova, II Senin, AA Zargarov, et al.
Recoverin is a zinc-binding protein.
J Proteome Res., 2 (2003), pp. 51-57
[14]
K Kashiwabara, H Nakamura, K Kishi, H Yagyu, G Sarashina, K Kobayashi, et al.
Cancer-associated retinopathy during treatment for small-cell lung carcinoma.
Intern Med., 38 (1999), pp. 597-601
[15]
R Kaiser.
Paraneoplastic neurologic syndromes. Diagnostic and pathogenetic significance of autoantibodies.
Nervenarzt., 70 (1999), pp. 688-701
[16]
Y Yamaji, S Matsubara, I Yamadori, M Sato, J Fujita, J Takahara.
Characterization of a small-cell lung carcinoma cell line from a patient with cancer-associated retinopathy.
Int J Cancer, 65 (1996), pp. 671-676
[17]
S Matsubara, Y Yamaji, T Fujita, T Kanayama, I Yamadori, M Sato, et al.
Cancer-associated retinopathy syndrome: a case of small cell lung cancer expressing recoverin immunoreactivity.
Lung Cancer, 14 (1996), pp. 265-271
[18]
JF McGinnis, B Austin, I Klisak, C Heinzmann, T Kojis, RS Sparkes, et al.
Chromosomal assignment of the human gene for the cancer-associated retinopathy protein (recoverin) to chromosome 17p13.1.
J Neurosci Res., 40 (1995), pp. 165-168
[19]
F Graus, R Dalmau, M Reñé, N Torá, N Malats, J Verschuuren, F Cardenal, et al.
Anti-Hu antibodies in patients with small-cell lung cancer: association with complete response to therapy and improved survival.
J Clin Oncol., 15 (1997), pp. 2866-2872
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