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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Background and objectives</span><p class="elsevierStyleSimplePara elsevierViewall">A few recent epidemiological findings indicate a link between atherosclerosis and some lung functions&#46; We studied further the relation between calcified chest atherosclerosis as seen in computed tomography &#40;CT&#41; and several lung functional parameters&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Male construction workers originally screened for occupational lung cancer with CT had their chest atherosclerosis &#40;aorta&#44; the origins of its cervical branches&#44; the coronary arteries and heart valves&#41; visually classified&#46; The relation between the atherosclerotic calcification scores and lung function &#40;total lung capacity &#91;TLC&#93;&#44; forced expiratory volume in one second &#91;FEV<span class="elsevierStyleInf">1</span>&#37;&#93;&#44; forced vital capacity &#91;FVC&#37;&#93;&#44; maximal expiratory flow when 50&#37; of FVC remains to be exhaled&#44; total and specific diffusing capacities&#59; all above expressed as percent of predicted value&#44; and the FEV<span class="elsevierStyleInf">1</span>&#47;FVC&#37; ratio&#41; were studied with the general linear model adjusted for smoking&#44; exposure years for asbestos&#44; and body mass index &#40;n &#61; 432&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">All lung functions except TLC showed significant negative associations with calcifications in aorta and in its branches&#46; TLC showed such association only with atherosclerosis in the ascending aorta&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Aortic atherosclerosis seems to be related with poor lung function&#46; This may be due to deteriorated bronchial circulation&#44; but other mechanisms can also be involved&#46; Lung function poorer than would be expected due to pulmonary reasons may indicate aortic atherosclerosis&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">Varios hallazgos epidemiol&#243;gicos recientes indican que hay una conexi&#243;n entre la aterosclerosis y algunas funciones pulmonares&#46; Examinamos en m&#225;s detalle la relaci&#243;n entre la aterosclerosis calcificada de t&#243;rax&#44; seg&#250;n se visualiza en la tomograf&#237;a computarizada &#40;TAC&#41;&#44; y varios par&#225;metros de funci&#243;n pulmonar&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">En obreros de la construcci&#243;n masculinos a quienes inicialmente se realiz&#243; una TAC para la detecci&#243;n precoz de c&#225;ncer de pulm&#243;n ocupacional&#44; se efectu&#243; tambi&#233;n una clasificaci&#243;n visual de la aterosclerosis en la zona tor&#225;cica &#40;aorta&#44; origen de arterias del cayado a&#243;rtico&#44; arterias coronarias y v&#225;lvulas card&#237;acas&#41;&#46; Se evalu&#243; la relaci&#243;n entre las puntuaciones de la calcificaci&#243;n ateroscler&#243;tica y los par&#225;metros de funci&#243;n pulmonar &#8211;capacidad pulmonar total &#40;TLC&#41;&#44; volumen espiratorio forzado en el primer segundo &#40;FEV<span class="elsevierStyleInf">1</span>&#37;&#41;&#44; capacidad vital forzada &#40;FVC&#37;&#41;&#44; flujo espiratorio m&#225;ximo cuando queda un 50&#37; de la FVC por espirar y capacidades de difusi&#243;n total y espec&#237;fica &#40;todos ellos expresados como porcentajes del valor predicho&#41;&#44; as&#237; como el cociente FEV<span class="elsevierStyleInf">1</span>&#47;FVC&#37;&#8211; con un modelo lineal general ajustado para tabaquismo&#44; a&#241;os de exposici&#243;n al asbesto e &#237;ndice de masa corporal &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>432&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Todos los par&#225;metros de la funci&#243;n pulmonar&#44; salvo la TLC&#44; mostraron asociaciones negativas y significativas con la calcificaci&#243;n de la aorta y de sus ramas&#46; La TLC s&#243;lo mostr&#243; tal asociaci&#243;n con la aterosclerosis en la aorta ascendente&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La aterosclerosis a&#243;rtica parece estar relacionada con una funci&#243;n pulmonar deficiente&#46; Esto puede deberse al deterioro de la circulaci&#243;n bronquial&#44; pero tambi&#233;n pueden intervenir otros mecanismos&#46; Una funci&#243;n pulmonar m&#225;s deficiente de lo esperado seg&#250;n las condiciones pulmonares puede indicar aterosclerosis a&#243;rtica&#46;</p>"
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Vol. 45. Issue 8.
Pages 376-381 (August 2009)
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Vol. 45. Issue 8.
Pages 376-381 (August 2009)
Original article
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Relation Between Atherosclerotic Calcifications Detected in Chest Computed Tomography and Lung Function
Relación entre las calcificaciones ateroscleróticas en el tórax detectadas mediante tomografía computarizada y la función pulmonar
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Tapio Vehmasa,
Corresponding author
tapio.vehmas@ttl.fi

Corresponding author.
, Asta Hiltinunenb, Päivi Leino-Arjasa, Päivi Piiriläc
a Health and Work Ability, Finnish Institute of Occupational Health, Helsinki, Finland
b Department of Radiology, Central Hospital of Länsi-Pohja, Kemi, Finland
c Department of Clinical Physiology, Helsinki University Hospital, HUSLAB, Helsinki, Finland
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Abstract
Background and objectives

A few recent epidemiological findings indicate a link between atherosclerosis and some lung functions. We studied further the relation between calcified chest atherosclerosis as seen in computed tomography (CT) and several lung functional parameters.

Patients and methods

Male construction workers originally screened for occupational lung cancer with CT had their chest atherosclerosis (aorta, the origins of its cervical branches, the coronary arteries and heart valves) visually classified. The relation between the atherosclerotic calcification scores and lung function (total lung capacity [TLC], forced expiratory volume in one second [FEV1%], forced vital capacity [FVC%], maximal expiratory flow when 50% of FVC remains to be exhaled, total and specific diffusing capacities; all above expressed as percent of predicted value, and the FEV1/FVC% ratio) were studied with the general linear model adjusted for smoking, exposure years for asbestos, and body mass index (n = 432).

Results

All lung functions except TLC showed significant negative associations with calcifications in aorta and in its branches. TLC showed such association only with atherosclerosis in the ascending aorta.

Conclusions

Aortic atherosclerosis seems to be related with poor lung function. This may be due to deteriorated bronchial circulation, but other mechanisms can also be involved. Lung function poorer than would be expected due to pulmonary reasons may indicate aortic atherosclerosis.

Keywords:
Atherosclerosis
Respiratory function tests
Tomography spiral computed
Resumen
Introducción

Varios hallazgos epidemiológicos recientes indican que hay una conexión entre la aterosclerosis y algunas funciones pulmonares. Examinamos en más detalle la relación entre la aterosclerosis calcificada de tórax, según se visualiza en la tomografía computarizada (TAC), y varios parámetros de función pulmonar.

Pacientes y métodos

En obreros de la construcción masculinos a quienes inicialmente se realizó una TAC para la detección precoz de cáncer de pulmón ocupacional, se efectuó también una clasificación visual de la aterosclerosis en la zona torácica (aorta, origen de arterias del cayado aórtico, arterias coronarias y válvulas cardíacas). Se evaluó la relación entre las puntuaciones de la calcificación aterosclerótica y los parámetros de función pulmonar –capacidad pulmonar total (TLC), volumen espiratorio forzado en el primer segundo (FEV1%), capacidad vital forzada (FVC%), flujo espiratorio máximo cuando queda un 50% de la FVC por espirar y capacidades de difusión total y específica (todos ellos expresados como porcentajes del valor predicho), así como el cociente FEV1/FVC%– con un modelo lineal general ajustado para tabaquismo, años de exposición al asbesto e índice de masa corporal (n=432).

Resultados

Todos los parámetros de la función pulmonar, salvo la TLC, mostraron asociaciones negativas y significativas con la calcificación de la aorta y de sus ramas. La TLC sólo mostró tal asociación con la aterosclerosis en la aorta ascendente.

Conclusiones

La aterosclerosis aórtica parece estar relacionada con una función pulmonar deficiente. Esto puede deberse al deterioro de la circulación bronquial, pero también pueden intervenir otros mecanismos. Una función pulmonar más deficiente de lo esperado según las condiciones pulmonares puede indicar aterosclerosis aórtica.

Palabras clave:
Aterosclerosis
Pruebas de función respiratoria
Tomografía computarizada helicoidal
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