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Vol. 43. Issue 1.
Pages 49-51 (January 2007)
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Vol. 43. Issue 1.
Pages 49-51 (January 2007)
Case Reports
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Prolonged Therapeutic Response to Voriconazole in a Case of Allergic Bronchopulmonary Aspergillosis
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Rafael Bandrés Gimeno
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rafaelbandres@yahoo.es

Correspondence: Dr. R. Bandrés Gimeno. Servicio de Neumología. Hospital Xeral de Vigo. Complexo HospitalarioUniversitario de Vigo. Pizarro, 22. 36204 Vigo. Pontevedra. España
, María José Muñoz Martínez
Servicio de Neumología, Hospital Xeral de Vigo, Complexo Hospitalario Universitario de Vigo, Vigo, Pontevedra, Spain
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Allergic bronchopulmonary aspergillosis is a lung disease characterized by an immune response to several antigens of Aspergillus species. Corticosteroids are the treatment of choice in the acute phase, although some studies have shown the efficacy of itraconazole. We describe the case of a favorable, prolonged therapeutic response to voriconazole in a patient with allergic bronchopulmonary aspergillosis who did not tolerate itraconazole.

Key words:
Bronchopulmonary aspergillosis
Aspergillosis
Aspergillus species
Voriconazole
Therapeutics

La aspergilosis broncopulmonar alérgica es una enferme-dad pulmonar que se caracteriza por una respuesta inmuno-lógica a múltiples antígenos de la especie Aspergillus. El tra-tamiento de elección en la fase aguda son los corticoides, pero algunos estudios han demostrado la eficacia del itraco-nazol. Describimos un caso de respuesta terapéutica favorable y prolongada con voriconazol en una paciente con broncoaspergilosis alérgica que no toleró el itraconazol.

Palabras clave:
Aspergilosis broncopulmonar alérgica
Aspergilosis
Aspergillus
Voriconazol
Tratamiento
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REFERENCES
[1]
PA Greenberger, R Patterson.
Allergic bronchopulmonary aspergillosis and the evaluation of the patient with asthma.
J Allergy Clin Immunol, 81 (1988), pp. 646-650
[2]
M Skov, N Hoiby, C Koch.
Itraconazole treatment of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis.
Allergy, 57 (2002), pp. 723-728
[3]
PA Greenberger.
Allergic bronchopulmonary aspergillosis.
J Allergy Clin Immunol, 110 (2002), pp. 685-692
[4]
DC Currie, C Lueck, HJ Milburn, et al.
Controlled trial of natamycin in the treatment of allergic bronchopulmonary aspergillosis.
Thorax, 45 (1990), pp. 447-450
[5]
DJ Shale, JA Faux, DJ Lane.
Trial of ketoconazole in noninvasive pulmonary aspergillosis.
Thorax, 42 (1987), pp. 26-31
[6]
GK Crompton, LJ Milne.
Treatment of pulmonary aspergillosis with clotrimazole.
Br J Dis Chest, 67 (1973), pp. 301-307
[7]
DW Denning, JE van Wye, NJ Lewiston, DA Stevens.
Adjunctive therapy of allergic bronchopulmonary aspergillosis with itraconazole.
Chest, 100 (1991), pp. 813-819
[8]
F Salez, A Brichet, S Desurmont, et al.
Effects of itraconazole therapy in allergic bronchopulmonary aspergillosis.
Chest, 116 (1999), pp. 1665-1668
[9]
DA Stevens, HJ Schwartz, JY Lee, et al.
A randomized trial of itraconazole in allergic bronchopulmonary aspergillosis.
N Engl J Med, 342 (2000), pp. 756-762
[10]
M Murphy, EM Bernard, T Ishimaru, D Armstrong.
Activity of voriconazole (UK-109,496) against clinical isolates of Aspergillus species and its effectiveness in an experimental model of invasive pulmonary aspergillosis.
Antimicrob Agents Chemother, 41 (1997), pp. 696-698
[11]
R Herbrecht, DW Denning, TF Patterson, et al.
Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis.
N Engl J Med, 347 (2002), pp. 408-415
[12]
DW Denning, P Ribaud, N Milpied, et al.
Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosis.
Clin Infect Dis, 34 (2002), pp. 563-571
[13]
M Rosenberg, R Patterson, R Mintzer, et al.
Clinical and immunologic criteria for the diagnosis of allergic bronchopulmonary aspergillosis.
Ann Intern Med, 86 (1977), pp. 405-414
[14]
PA Greenberger, R Patterson.
Diagnosis and management of allergic bronchopulmonary aspergillosis.
Ann Allergy, 56 (1986), pp. 444-448
Copyright © 2007. Sociedad Española de Neumología y Cirugía Torácica (SEPAR)
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