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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Our objective was to evaluate <span class="elsevierStyleItalic">ERBB2</span> oncogene amplification using fluorescence in situ hybridization &#40;FISH&#41; and protein overexpression using immunohistochemical techniques&#44; and to explore their possible prognostic value in a series of patients with small cell carcinoma&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Included in the study were 99 patients with small cell tumors&#44; classified in 2 broad groups&#58; patients with limited or locally advanced disease and patients with disseminated disease&#46; Material for study was obtained in 97&#37; of the cases &#40;96&#47;99&#41; by means of endoscopic biopsy and by tomography-guided needle biopsy in the remaining 3&#37; &#40;3&#47;99&#41;&#46; Survival was analyzed using the Kaplan-Meier method&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The 92 men &#40;92&#46;9&#37;&#41; and 7 women &#40;7&#46;1&#37;&#41; in the study had a mean &#40;SD&#41; age of 62&#46;9 &#40;10&#46;4&#41; years &#40;range&#44; 36&#8211;81 years&#41;&#59; 39&#46;4&#37; &#40;n&#61;39&#41; and 60&#46;6&#37; &#40;n&#61;60&#41; of the subjects had limited and disseminated disease&#44; respectively&#46; ERBB2 protein overexpression was observed in 26&#46;3&#37; of the patients &#40;n&#61;26&#41;&#44; 15&#46;4&#37; &#40;n&#61;4&#41; of whom had limited disease and 84&#46;6&#37; &#40;n&#61;22&#41; of whom had disseminated disease &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;005&#41;&#46; Although mean survival was slightly longer for patients who were negative for ERBB2 protein overexpression&#44; the difference was not statistically significant&#46; FISH identified gene amplification in 6&#46;3&#37; &#40;1 in16&#41; of the studied cases &#40;ratio&#44; 2&#46;3&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The protein product of the <span class="elsevierStyleItalic">ERBB2</span> oncogene is overexpressed in 33&#46;3&#37; of small cell lung carcinomas and is associated with the presence of disseminated disease&#46; Further studies are necessary to evaluate the possible benefits of specific treatment&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El prop&#243;sito de nuestro estudio ha sido evaluar la sobreexpresi&#243;n proteica de <span class="elsevierStyleItalic">c-erbB-2</span> mediante t&#233;cnicas de inmunohistoqu&#237;mica y la amplificaci&#243;n del oncog&#233;n mediante hibridaci&#243;n in situ fluorescente&#44; en una serie de carcinomas microc&#237;ticos&#44; correlacion&#225;ndola con las posibles implicaciones pron&#243;sticas&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; a 99 pacientes con tumores microc&#237;ticos clasificados en 2 grandes grupos&#58; enfermedad limitada o localmente avanzada y enfermedad diseminada&#46; El material para estudio se obtuvo mediante biopsia endosc&#243;pica en el 97&#37; de los casos &#40;96&#47;99&#41; o mediante punci&#243;n guiada por tomograf&#237;a computarizada en el 3&#37; restante &#40;3&#47;99&#41;&#46; La supervivencia se analiz&#243; con el m&#233;todo de Kaplan-Meier&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La media de edad &#177; desviaci&#243;n est&#225;ndar de los pacientes fue de 62&#44;9 &#177; 10&#44;4 a&#241;os &#40;rango&#58; 36&#8211;81&#41;&#46; El 92&#44;9&#37; &#40;n &#61; 92&#41; eran varones y el 7&#44;1&#37; mujeres &#40;n &#61; 7&#41;&#46; Un 39&#44;4&#37; &#40;n &#61; 39&#41; presentaba enfermedad limitada y el 60&#44;6&#37; &#40;n &#61; 60&#41; enfermedad diseminada&#46; La sobreexpresi&#243;n proteica de c-erbB-2 se observ&#243; en el 26&#44;3&#37; de los casos &#40;n &#61; 26&#41;&#44; de los cuales un 15&#44;4&#37; &#40;n &#61; 4&#41; presentaba enfermedad limitada y el 84&#44;6&#37; restante &#40;n &#61; 22&#41; enfermedad diseminada &#40;p &#61; 0&#44;005&#41;&#46; La media de supervivencia fue ligeramente mayor para los pacientes con c-erbB-2 negativo que en aqu&#233;llos con c-erbB-2 positivo&#44; pero esta diferencia no fue estad&#237;sticamente significativa&#46; La t&#233;cnica de hibridaci&#243;n in situ fluorescente mostr&#243; amplificaci&#243;n g&#233;nica en el 6&#44;3&#37; &#40;1&#47;16&#41; de los casos estudiados&#44; con un &#237;ndice de 2&#44;3&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El producto proteico del oncog&#233;n <span class="elsevierStyleItalic">c-erbB-2</span> se sobreexpresa en un 33&#44;3&#37; de los carcinomas microc&#237;ticos pulmonares y se asocia a la presencia de enfermedad diseminada&#46; Son necesarios nuevos estudios para evaluar el posible beneficio del tratamiento espec&#237;fico&#46;</p>"
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Vol. 44. Issue 3.
Pages 122-126 (January 2008)
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Vol. 44. Issue 3.
Pages 122-126 (January 2008)
Original Articles
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Prognostic Value of ERBB2 Amplification and Protein Expression in Small Cell Lung Cancer
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María Cebollero-Presmanesa,
Corresponding author
mpresmanes@hotmail.com

Correspondence: Dr M. Cebollero-Presmanes Servicio de Anatomía Patológica Hospital General Universitario Gregorio Marañón Dr. Esquerdo, 4628007 Madrid, Spain
, Nora Sánchez-Moraa,b, Ramón García-Gómezc, María Luisa Herranz Aladroa, Emilio Álvarez-Fernándeza
a Servicio de Anatomía Patológica, Hospital General Universitario Gregorio Marañón, Madrid, Spain
b Laboratorio Integrado de la Escuela de Medicina del Táchira (LABIEMET), Universidad de Los Andes, San Cristobal, Venezuela
c Servicio de Oncología. Hospital General Universitario Gregorio Marañón. Madrid. Spain
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Abstract
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Objective

Our objective was to evaluate ERBB2 oncogene amplification using fluorescence in situ hybridization (FISH) and protein overexpression using immunohistochemical techniques, and to explore their possible prognostic value in a series of patients with small cell carcinoma.

Patients and methods

Included in the study were 99 patients with small cell tumors, classified in 2 broad groups: patients with limited or locally advanced disease and patients with disseminated disease. Material for study was obtained in 97% of the cases (96/99) by means of endoscopic biopsy and by tomography-guided needle biopsy in the remaining 3% (3/99). Survival was analyzed using the Kaplan-Meier method.

Results

The 92 men (92.9%) and 7 women (7.1%) in the study had a mean (SD) age of 62.9 (10.4) years (range, 36–81 years); 39.4% (n=39) and 60.6% (n=60) of the subjects had limited and disseminated disease, respectively. ERBB2 protein overexpression was observed in 26.3% of the patients (n=26), 15.4% (n=4) of whom had limited disease and 84.6% (n=22) of whom had disseminated disease (P=.005). Although mean survival was slightly longer for patients who were negative for ERBB2 protein overexpression, the difference was not statistically significant. FISH identified gene amplification in 6.3% (1 in16) of the studied cases (ratio, 2.3).

Conclusions

The protein product of the ERBB2 oncogene is overexpressed in 33.3% of small cell lung carcinomas and is associated with the presence of disseminated disease. Further studies are necessary to evaluate the possible benefits of specific treatment.

Key words:
SSmall cell carcinoma of the lung
ERBB2 oncogene
Prognosis
Objetivo

El propósito de nuestro estudio ha sido evaluar la sobreexpresión proteica de c-erbB-2 mediante técnicas de inmunohistoquímica y la amplificación del oncogén mediante hibridación in situ fluorescente, en una serie de carcinomas microcíticos, correlacionándola con las posibles implicaciones pronósticas.

Pacientes y métodos

Se incluyó a 99 pacientes con tumores microcíticos clasificados en 2 grandes grupos: enfermedad limitada o localmente avanzada y enfermedad diseminada. El material para estudio se obtuvo mediante biopsia endoscópica en el 97% de los casos (96/99) o mediante punción guiada por tomografía computarizada en el 3% restante (3/99). La supervivencia se analizó con el método de Kaplan-Meier.

Resultados

La media de edad ± desviación estándar de los pacientes fue de 62,9 ± 10,4 años (rango: 36–81). El 92,9% (n = 92) eran varones y el 7,1% mujeres (n = 7). Un 39,4% (n = 39) presentaba enfermedad limitada y el 60,6% (n = 60) enfermedad diseminada. La sobreexpresión proteica de c-erbB-2 se observó en el 26,3% de los casos (n = 26), de los cuales un 15,4% (n = 4) presentaba enfermedad limitada y el 84,6% restante (n = 22) enfermedad diseminada (p = 0,005). La media de supervivencia fue ligeramente mayor para los pacientes con c-erbB-2 negativo que en aquéllos con c-erbB-2 positivo, pero esta diferencia no fue estadísticamente significativa. La técnica de hibridación in situ fluorescente mostró amplificación génica en el 6,3% (1/16) de los casos estudiados, con un índice de 2,3.

Conclusiones

El producto proteico del oncogén c-erbB-2 se sobreexpresa en un 33,3% de los carcinomas microcíticos pulmonares y se asocia a la presencia de enfermedad diseminada. Son necesarios nuevos estudios para evaluar el posible beneficio del tratamiento específico.

Palabras clave:
Carcinoma microcítico de pulmón
c-erbB-2
Pronóstico
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