Original Articles
Prognostic Value of ERBB2 Amplification and Protein Expression in Small Cell Lung Cancer
María Cebollero-Presmanesa,
, Nora Sánchez-Moraa,b, Ramón García-Gómezc, María Luisa Herranz Aladroa, Emilio Álvarez-Fernándeza
Corresponding author
mpresmanes@hotmail.com
Correspondence: Dr M. Cebollero-Presmanes Servicio de Anatomía Patológica Hospital General Universitario Gregorio Marañón Dr. Esquerdo, 4628007 Madrid, Spain
Correspondence: Dr M. Cebollero-Presmanes Servicio de Anatomía Patológica Hospital General Universitario Gregorio Marañón Dr. Esquerdo, 4628007 Madrid, Spain
a Servicio de Anatomía Patológica, Hospital General Universitario Gregorio Marañón, Madrid, Spain
b Laboratorio Integrado de la Escuela de Medicina del Táchira (LABIEMET), Universidad de Los Andes, San Cristobal, Venezuela
c Servicio de Oncología. Hospital General Universitario Gregorio Marañón. Madrid. Spain
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Hospital General Universitario Gregorio Marañón. Madrid. Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr M. Cebollero-Presmanes Servicio de Anatomía Patológica Hospital General Universitario Gregorio Marañón Dr. Esquerdo, 4628007 Madrid, Spain" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-10-19" "fechaAceptado" => "2007-09-06" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec155176" "palabras" => array:3 [ 0 => "SSmall cell carcinoma of the lung" 1 => "<span class="elsevierStyleItalic">ERBB2</span> oncogene" 2 => "Prognosis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155175" "palabras" => array:3 [ 0 => "Carcinoma microcítico de pulmón" 1 => "<span class="elsevierStyleItalic">c-erbB-2</span>" 2 => "Pronóstico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Our objective was to evaluate <span class="elsevierStyleItalic">ERBB2</span> oncogene amplification using fluorescence in situ hybridization (FISH) and protein overexpression using immunohistochemical techniques, and to explore their possible prognostic value in a series of patients with small cell carcinoma.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Included in the study were 99 patients with small cell tumors, classified in 2 broad groups: patients with limited or locally advanced disease and patients with disseminated disease. Material for study was obtained in 97% of the cases (96/99) by means of endoscopic biopsy and by tomography-guided needle biopsy in the remaining 3% (3/99). Survival was analyzed using the Kaplan-Meier method.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The 92 men (92.9%) and 7 women (7.1%) in the study had a mean (SD) age of 62.9 (10.4) years (range, 36–81 years); 39.4% (n=39) and 60.6% (n=60) of the subjects had limited and disseminated disease, respectively. ERBB2 protein overexpression was observed in 26.3% of the patients (n=26), 15.4% (n=4) of whom had limited disease and 84.6% (n=22) of whom had disseminated disease (<span class="elsevierStyleItalic">P</span>=.005). Although mean survival was slightly longer for patients who were negative for ERBB2 protein overexpression, the difference was not statistically significant. FISH identified gene amplification in 6.3% (1 in16) of the studied cases (ratio, 2.3).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The protein product of the <span class="elsevierStyleItalic">ERBB2</span> oncogene is overexpressed in 33.3% of small cell lung carcinomas and is associated with the presence of disseminated disease. Further studies are necessary to evaluate the possible benefits of specific treatment.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El propósito de nuestro estudio ha sido evaluar la sobreexpresión proteica de <span class="elsevierStyleItalic">c-erbB-2</span> mediante técnicas de inmunohistoquímica y la amplificación del oncogén mediante hibridación in situ fluorescente, en una serie de carcinomas microcíticos, correlacionándola con las posibles implicaciones pronósticas.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluyó a 99 pacientes con tumores microcíticos clasificados en 2 grandes grupos: enfermedad limitada o localmente avanzada y enfermedad diseminada. El material para estudio se obtuvo mediante biopsia endoscópica en el 97% de los casos (96/99) o mediante punción guiada por tomografía computarizada en el 3% restante (3/99). La supervivencia se analizó con el método de Kaplan-Meier.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La media de edad ± desviación estándar de los pacientes fue de 62,9 ± 10,4 años (rango: 36–81). El 92,9% (n = 92) eran varones y el 7,1% mujeres (n = 7). Un 39,4% (n = 39) presentaba enfermedad limitada y el 60,6% (n = 60) enfermedad diseminada. La sobreexpresión proteica de c-erbB-2 se observó en el 26,3% de los casos (n = 26), de los cuales un 15,4% (n = 4) presentaba enfermedad limitada y el 84,6% restante (n = 22) enfermedad diseminada (p = 0,005). La media de supervivencia fue ligeramente mayor para los pacientes con c-erbB-2 negativo que en aquéllos con c-erbB-2 positivo, pero esta diferencia no fue estadísticamente significativa. La técnica de hibridación in situ fluorescente mostró amplificación génica en el 6,3% (1/16) de los casos estudiados, con un índice de 2,3.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El producto proteico del oncogén <span class="elsevierStyleItalic">c-erbB-2</span> se sobreexpresa en un 33,3% de los carcinomas microcíticos pulmonares y se asocia a la presencia de enfermedad diseminada. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 2 | 8 |
| 2024 October | 25 | 19 | 44 |
| 2024 September | 25 | 21 | 46 |
| 2024 August | 38 | 37 | 75 |
| 2024 July | 21 | 23 | 44 |
| 2024 June | 29 | 27 | 56 |
| 2024 May | 40 | 30 | 70 |
| 2024 April | 20 | 25 | 45 |
| 2024 March | 23 | 22 | 45 |
| 2024 February | 13 | 18 | 31 |
| 2023 March | 2 | 1 | 3 |
| 2023 February | 16 | 24 | 40 |
| 2023 January | 17 | 32 | 49 |
| 2022 December | 18 | 29 | 47 |
| 2022 November | 22 | 32 | 54 |
| 2022 October | 16 | 23 | 39 |
| 2022 September | 16 | 31 | 47 |
| 2022 August | 18 | 44 | 62 |
| 2022 July | 20 | 43 | 63 |
| 2022 June | 13 | 41 | 54 |
| 2022 May | 16 | 30 | 46 |
| 2022 April | 15 | 26 | 41 |
| 2022 March | 19 | 39 | 58 |
| 2022 February | 14 | 26 | 40 |
| 2022 January | 13 | 30 | 43 |
| 2021 December | 16 | 45 | 61 |
| 2021 November | 15 | 41 | 56 |
| 2021 October | 28 | 48 | 76 |
| 2021 September | 23 | 55 | 78 |
| 2021 August | 18 | 33 | 51 |
| 2021 July | 12 | 23 | 35 |
| 2021 June | 13 | 29 | 42 |
| 2021 May | 11 | 25 | 36 |
| 2021 April | 31 | 44 | 75 |
| 2021 March | 20 | 22 | 42 |
| 2021 February | 11 | 13 | 24 |
| 2021 January | 11 | 9 | 20 |
| 2020 December | 10 | 16 | 26 |
| 2020 November | 8 | 15 | 23 |
| 2020 October | 7 | 6 | 13 |
| 2020 September | 2 | 7 | 9 |
| 2020 August | 7 | 10 | 17 |
| 2020 July | 18 | 14 | 32 |
| 2020 June | 7 | 5 | 12 |
| 2020 May | 9 | 8 | 17 |
| 2020 April | 18 | 18 | 36 |
| 2020 March | 25 | 11 | 36 |
| 2020 February | 67 | 23 | 90 |
| 2020 January | 46 | 21 | 67 |
| 2019 December | 16 | 29 | 45 |
| 2019 November | 26 | 13 | 39 |
| 2019 October | 8 | 8 | 16 |
| 2019 September | 6 | 15 | 21 |
| 2019 August | 18 | 11 | 29 |
| 2019 July | 11 | 15 | 26 |
| 2019 June | 9 | 9 | 18 |
| 2019 May | 11 | 20 | 31 |
| 2019 April | 8 | 34 | 42 |
| 2019 March | 7 | 19 | 26 |
| 2019 February | 14 | 13 | 27 |
| 2019 January | 3 | 9 | 12 |
| 2018 December | 10 | 12 | 22 |
| 2018 November | 15 | 9 | 24 |
| 2018 October | 19 | 12 | 31 |
| 2018 September | 8 | 12 | 20 |
| 2018 May | 2 | 0 | 2 |
| 2018 April | 11 | 5 | 16 |
| 2018 March | 3 | 3 | 6 |
| 2018 February | 6 | 11 | 17 |
| 2018 January | 6 | 6 | 12 |
| 2017 December | 6 | 7 | 13 |
| 2017 November | 6 | 6 | 12 |
| 2017 October | 7 | 10 | 17 |
| 2017 September | 6 | 5 | 11 |
| 2017 August | 10 | 16 | 26 |
| 2017 July | 13 | 12 | 25 |
| 2017 June | 9 | 9 | 18 |
| 2017 May | 7 | 9 | 16 |
| 2017 April | 4 | 8 | 12 |
| 2017 March | 4 | 7 | 11 |
| 2017 February | 5 | 9 | 14 |
| 2017 January | 2 | 3 | 5 |
| 2016 December | 2 | 9 | 11 |
| 2016 November | 11 | 13 | 24 |
| 2016 October | 11 | 9 | 20 |
| 2016 September | 14 | 6 | 20 |
| 2016 August | 8 | 3 | 11 |
| 2016 July | 7 | 0 | 7 |
| 2016 March | 2 | 0 | 2 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 45 | 6 | 51 |
| 2015 September | 39 | 8 | 47 |
| 2015 August | 42 | 10 | 52 |
| 2015 July | 53 | 5 | 58 |
| 2015 June | 34 | 8 | 42 |
| 2015 May | 56 | 12 | 68 |
| 2015 April | 38 | 10 | 48 |
| 2015 March | 34 | 4 | 38 |
| 2015 February | 32 | 1 | 33 |
| 2015 January | 35 | 3 | 38 |
| 2014 December | 40 | 2 | 42 |
| 2014 November | 27 | 8 | 35 |
| 2014 October | 73 | 9 | 82 |
| 2014 September | 41 | 8 | 49 |
| 2014 August | 44 | 13 | 57 |
| 2014 July | 43 | 6 | 49 |
| 2014 June | 67 | 9 | 76 |
| 2014 May | 91 | 11 | 102 |
| 2014 April | 75 | 3 | 78 |
| 2014 March | 69 | 8 | 77 |
| 2014 February | 65 | 7 | 72 |
| 2014 January | 45 | 6 | 51 |
| 2013 December | 38 | 9 | 47 |
| 2013 November | 32 | 6 | 38 |
| 2013 October | 34 | 6 | 40 |
| 2013 September | 45 | 10 | 55 |
| 2013 August | 36 | 7 | 43 |
| 2013 July | 51 | 14 | 65 |
| 2013 June | 32 | 9 | 41 |
| 2013 May | 32 | 6 | 38 |
| 2013 April | 15 | 1 | 16 |
| 2013 March | 6 | 2 | 8 |
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