Poliquimioterapia secuencial (carboplatino/vp-16) versus alternante (carboplatino/vp-16 y ciclofosfamida/vincristina/adriamicina) en el carcinoma microcítico de pulmón

Sánchez de Cos Escuín, J.; Masa Jiménez, F.; de la Cruz Ríos, J.L.; Martínez Verdasco, A.

doi:10.1016/S0300-2896(15)31572-6

Archivos de Bronconeumología

ISSN: 0300-2896

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Vol. 26. Issue 7.

Pages 292-296 (October 1990)

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Pages 292-296 (October 1990)

DOI: 10.1016/S0300-2896(15)31572-6

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Poliquimioterapia secuencial (carboplatino/vp-16) versus alternante (carboplatino/vp-16 y ciclofosfamida/vincristina/adriamicina) en el carcinoma microcítico de pulmón

Sequential polychemotherapy (carboplatinum/VP-16) vs alternating (carboplatinum/VP-16) and cyclophosphamide/vincristine/adriamicine in the treatment of microcytic carcinoma of the lung

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J. Sánchez de Cos Escuín, F. Masa Jiménez, J.L. de la Cruz Ríos, A. Martínez Verdasco

Unidad de Neumología. Servicio de Medicina Interna. Hospital de la S.S. San Pedro de Alcantara. Cáceres

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Se analizan los resultados obtenidos en el tratamiento del carcinoma microcítico de pulmón mediante 2 pautas de poliquimioterapia: A (secuencial: 6 ciclos de carboplatino y VP16, intervalados cada 21 días) y B (alternante: ciclos 1, 3 y 5 iguales al anterior y ciclos 2, 4 y 6 con ciclofosfamida, vincristina y adriamicina). Resultaron evaluables 37 pacientes: 24 de la pauta A y 13 de la B. Se obtuvo un 100% de respuestas globales (40% de respuestas completas [RC] y 60% de parciales [RP]) en casos de enfermedad limitada con ambos regímenes. En casos de enfermedad extendida, hubo un 78,5% de respuestas globales con la pauta A (21,4% RC y 57,1% RP) y 87,5% con la B (25% RC, y 62,5% RP). Aunque las tasas de respuesta fueron similares, la pauta B fue mejor tolerada, permitiendo un mayor grado de cumplimiento de la dosis (diferencia estadística casi significativa: p < 0,1). Sólo hubo un fallecimiento debido a citostáticos (pauta A) y los efectos tóxicos graves fueron escasos en ambos grupos.

We analyze the results obtained in the treatment of the microcytic carcinoma of the lung using two types of polychemotherapy: A (sequential: 6 cycles of carboplatinum and VP-16 with 21 days interval between them) and B: (alternating: cycles number 1,3, and S identical to the previous schedule and cycles number 2,4, and 6 with cyclophosphamide, vincristine and adriamicine). We included for the analysis 37 patients: 24 with A model and 13 with type B. In cases of limited disease we obtained a 100% of responses (40% of complete response (CR) and 60% of partial result (PR)) using both regimes. In cases of disseminated illness we observed 78.5 of global responses with model A (21.4% CR and 57.1 PR) and 87.5 with type B (25% CR and 62.5% PR). The regime B was more well tolerated than model A and although the rates of response were comparable, patients treated with model B had a higher degree of fulfilment of the doses (differences nearly significant: p< 0.1). We observed a death dne to the cytostatic treatment in schedule A. The toxic effects were scanty in both groups of patients.

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