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However&#44; NIV application in exacerbated DMD patients is still controversial and not indicated by major guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">3</span></a><span class="elsevierStyleSup">&#44;</span> The aim of our study was to evaluate clinical status and outcomes in DMD patients being administered NIV for ARF&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We collected and reviewed all of the medical records of the DMD patients with ARF who were admitted to our adult 4 bed Respiratory ICU &#40;RICU&#41; at the University of Padua Medical Center between January 1&#44; 2005 and December 31&#44; 2019&#46; Ethical approval was waived by the local Ethics Committee in view of the fact that the study was retrospective and not prepared according to a research project&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">At the time of admission to the RICU&#44; the clinical and physiologic parameters of these patients were consistent with ARF&#46; In particular&#44; each of them presented at least one of the following&#58; &#40;1&#41; respiratory distress&#59; &#40;2&#41; hypoxemia and&#47;or hypercapnia&#59; &#40;3&#41; acute respiratory acidosis&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">4</span></a> Patients who had received NIV as first-line ventilatory treatment were included in the study&#59; those who had a tracheostomy tube in place or showed an immediate need for Endotracheal Intubation &#40;ETI&#41;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">5</span></a> were excluded&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">All hospital charts were reviewed for patients&#8217; baseline clinical&#44; demographic and pulmonary function data after informed consent release forms were obtained&#46; Clinical&#44; laboratory and blood gas data at RICU admission were also recorded and analyzed&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Causes of ARF were classified as&#58; upper respiratory tract infection &#40;URTI&#41;&#59; acute decompensated heart failure &#40;ADHF&#41;&#59; pneumonia&#59; and other &#40;e&#46;g&#46;&#44; pneumothorax&#44; pulmonary thromboembolism&#44; dysphagia with aspiration&#44; gastroparesis&#47;malnutrition&#44; acute gastrointestinal distension&#44; abuse of sedatives&#41;&#46; The diagnosis of URTI was based on the presence of one or more of the following symptoms or signs&#58; fever&#44; throat irritation or sore throat&#44; hoarseness<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">6</span></a>&#59; the diagnoses of pneumonia and&#47;or ADHF were based on major guidelines&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">7&#44;8</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The decision to begin NIV was usually made by the attending physician&#44; according to the hospital internal protocol&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">9</span></a> NIV was usually delivered using a portable ventilator set in assisted pressure-control ventilation &#40;APCV&#41; mode&#46; A commercial full-face mask was used when NIV was initiated and in some cases it was substituted by a nasal mask after the first hours of ventilation&#46; In the event of NIV failure&#44; the patients were shifted from NIV to Invasive Mechanical Ventilation &#40;IMV&#41; by ETI unless they had previously declared that they did not wish to be intubated&#46; Mechanical In-Exsufflation &#40;MI-E&#41; was usually administered to those patients showing bronchial mucous encumbrance and oxyhemoglobin desaturation secondary to secretion retention&#44; according to the hospital internal protocol&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The patients were divided into 2 groups depending on their NIV response&#46; &#8220;NIV success group&#8221; was made up of those individuals who avoided ETI&#44; were discharged from RICU and survived for at least 48<span class="elsevierStyleHsp" style=""></span>h after being transferred to the respiratory ward&#46; &#8220;NIV failure group&#8221; was made up of those subjects who required ETI or died while on NIV support&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">During the study period&#44; 51 patients were admitted to our RICU for ARF with a primary diagnosis of DMD&#46; Seven &#40;13&#46;7&#37;&#41; had a tracheostomy tube in place and were administered IMV via tracheal cannula&#44; 2 &#40;3&#46;9&#37;&#41; were intubated at admission&#44; while all the remaining 42 &#40;82&#46;3&#37;&#41;&#44; received NIV as the first-line ventilatory intervention and were considered eligible to participate in our retrospective study&#46; No patient experienced repeated episodes of ARF&#46; Of notice&#44; RICU admissions were evenly distributed during the study period&#46; Baseline demographic&#44; clinical&#44; pulmonary and cardiac function&#44; of the patients are outlined in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Conditions associated with the onset of ARF in the patients studied included URTI &#40;19 cases&#41;&#59; ADHF &#40;5 cases&#41;&#59; pneumonia &#40;4 cases&#41;&#59; and other conditions &#40;14 cases&#41;&#46; The patients were administered NIV in APCV&#46; The initial inspiratory pressure above PEEP was 12 &#40;8&#8211;25&#41; cmH<span class="elsevierStyleInf">2</span>O&#46; All subjects were fully cooperative during NIV and did not require any sedation&#46; NIV was successful in 36 patients &#40;85&#46;7&#37;&#41;&#44; while unsuccessful in the remaining 6 &#40;14&#46;3&#37;&#41;&#46; The median time from NIV initiation to intubation was 3&#46;5 &#40;1&#8211;11&#41; days&#46; Among patients who failed NIV&#44; the cause of ARF was dysphagia with aspiration in 3 cases&#59; ADHF in 2 cases&#59; and pneumonia in 1 case&#46; Causes of NIV failure were failure to adequately correct hypercapnia and exhaustion &#40;3 cases&#41;&#44; persistent accumulation of bronchial secretions &#40;2 cases&#41;&#44; and severe hemodynamic instability &#40;1 case&#41;&#46; Two patients died following intubation while on IMV support&#59; the remaining four required tracheostomy due to difficult weaning and underwent long-term invasive ventilation&#46; No major NIV complication was observed&#44; while minor complications occurred in 4 patients &#40;nasal skin lesions in 3 cases and acute bowel distension in 1 case&#41;&#46; All 36 patients successfully treated and 4 out of 6 who failed NIV were discharged alive from hospital&#46; Patients&#8217; characteristics at RICU admission are outlined in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; The median survival of the 42 NIV patients after RICU admission was 67&#46;1 &#40;95&#37;CI&#44; 15&#46;0 to 125&#46;4&#41; days&#46; Survival was significantly reduced for patients who failed NIV&#44; compared to those who succeeded &#91;median survival time&#58; 11&#46;7 &#40;95&#37;CI&#44; 0&#46;0 to 131&#46;0&#41; vs 85&#46;9 &#40;95&#37;CI&#44; 24&#46;9 to 125&#46;4&#41; days&#93;&#44; with an HR of dying of 3&#46;91 &#40;95&#37;CI&#44; 1&#46;10 to 13&#46;93&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0351&#41;&#46; None of the covariates had a significant effect on NIV failure&#46; However&#44; patients who did not respond to NIV were younger than those who succeeded &#91;15 &#40;14&#8211;30&#41; vs&#46; 24&#46;5 &#40;14&#8211;41&#41; yrs&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0201&#93;&#59; moreover&#44; patients&#8217; characteristics at RICU admission showed greater HR values &#91;123&#46;0 &#40;120&#46;0&#8211;134&#46;0&#41; vs&#46; 104&#46;0 &#40;45&#46;0&#8211;112&#46;0&#41; b&#47;min&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0095&#93;&#44; total WBC count &#91;13&#46;2 &#40;11&#46;06&#8211;17&#46;80&#41; vs&#46; 8&#46;65 &#40;2&#46;06&#8211;18&#46;02&#41;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0113&#93; and SaO<span class="elsevierStyleInf">2</span> &#91;98 &#40;94&#46;8&#8211;99&#46;2&#41; vs&#46; 95&#46;1 &#40;88&#46;9&#8211;99&#41;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;011&#93; for failures&#44; as opposed to successes &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">The use of NIV in DMD patients for ARF is still debated&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">10&#8211;12</span></a> In our study&#44; the overall success rate of 86&#37; corroborates the positive role of NIV in avoiding tracheal intubation&#46; On our opinion&#44; high success rate of NIV treatment in our patients can be explained by several factors&#44; including the following&#46; First&#44; we used APCV&#44; a mode of partial ventilatory support found to be comfortable and minimally affected by patient&#8211;ventilator asynchrony in individuals with ventilatory failure of neuromuscular origin&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">13</span></a> Second&#44; we chose full-face mask as first choice&#46; Indeed&#44; nasal masks may be problematic in these patients because of weakness of masseter muscles&#44; causing incomplete jaw closing and major mouth air leaks&#46; Furthermore&#44; patients with ARF are characterized by mouth-breathing making nasal masks ineffective&#46; For these reasons&#44; despite a potentially increased risk of gastric distension and emesis into the mask&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">14</span></a> a full face mask was preferred in our patients&#46; Third&#44; the combined use of MI-E was effective in clearing bronchial secretions in most patients who developed bronchial mucous encumbrance and consequent oxyhemoglobin desaturation&#44; in keeping with previous data both in adults and children with NMD&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">15</span></a> Finally&#44; it is worth remarking that our team of pulmonary physicians and nurses has been involved in NIV treatment of NMD patients with ARF for over 20 years&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Notwithstanding the low NIV failure rate&#44; we believe that appropriate selection criteria for attempting NIV in this setting is a crucial unresolved issue&#46; Unfortunately&#44; we found none of the covariates associated with NIV failure&#46; Noteworthy&#44; patients who did not respond to NIV were younger than those who succeeded and reported dysphagia&#44; weight loss and aspiration in 3 out of 6 cases&#46; Swallowing disturbances resulting in increased risk of inhalation have been reported as a possible mechanism of ARF in boys with DMD<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">16</span></a> and a common cause of NIV failure in NMD patients&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">9</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Of interest&#44; there was a trend toward higher PaO<span class="elsevierStyleInf">2</span>&#44; SaO<span class="elsevierStyleInf">2</span>&#44; and PaCO<span class="elsevierStyleInf">2</span> values in the NIV failure compared to NIV success group&#46; We hypothesize that delivery of excessively high amounts of supplemental oxygen during transfer to our RICU might have increased the risk of NIV failure&#44; by depressing spontaneous ventilation&#46; Indeed&#44; oxygen therapy has been shown to reduce the drive to breathe and lead to CO<span class="elsevierStyleInf">2</span> retention in DMD patients during respiratory exacerbations&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">17</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Our study has important limitations&#44; being single-centered&#44; retrospective and observational&#46; It is important to remind&#44; however&#44; that prospective randomized trials in this patient population are unlikely to be performed because of the limited number of patients affected with DMD and of possible ethical issues&#46; The study&#39;s long time span is also a potential weakness&#46; Worth mentioning&#44; however&#44; we did not make significant changes in pharmacologic therapy and&#47;or supportive care during the study period&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Despite these major limitations&#44; our study indicates NIV to be a viable option in DMD patients showing signs of ARF as it can effectively reverse ARF in the majority of patients&#44; with the caveat that its use should be extremely careful in younger patients with dysphagia&#46;</p></span>"
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          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">BMI<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>Body Mass Index&#59; BNP<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>Brain Natriuretic Peptide&#59; CRP<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>C-Reactive Protein&#59; DMD<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>Duchenne Muscular Dystrophy&#59; ESR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>Erythrocyte Sedimentation Rate&#59; FVC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>Forced Vital Capacity&#59; MEP<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>Maximal Expiratory Pressure&#59; MIP<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>Maximal Inspiratory Pressure&#59; NA<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>not applicable&#59; NIV<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>Non-Invasive Ventilation&#59; NT-proBNP<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>N-terminal prohormone of Brain Natriuretic Peptide&#59; PEG<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>Percutaneous gastrostomy&#59; RICU<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>Respiratory Intensive Care Unit&#59; SaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>arterial oxygen saturation&#59; WBC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>White Blood Cell&#41;&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">p</span>-Values refer to differences between NIV success and NIV failure groups&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">All cases&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">NIV succes group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">NIV failure group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">Baseline demographic&#44; clinical and cardio-pulmonary function data</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Number of subjects</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36 &#40;85&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;14&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Age &#40;years&#41;&#44; median &#40;range&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;5 &#40;2&#8211;41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#46;5 &#40;14&#8211;41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;14&#8211;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0201&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>BMI &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#44; median &#40;range&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#46;1 &#40;9&#46;5&#8211;35&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#46;1 &#40;9&#46;5&#8211;35&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;7 &#40;14&#46;7&#8211;28&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;9615&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Age at DMD diagnosis &#40;years&#41;&#44; median &#40;range&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;0&#46;3&#8211;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;0&#46;3&#8211;11&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;7 &#40;0&#46;7&#8211;0&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;1932&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Pts with scoliosis&#44; <span class="elsevierStyleItalic">N</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37 &#40;88&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33 &#40;91&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;66&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;1414&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Pts with cardiomyopathy&#44; <span class="elsevierStyleItalic">N</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;45&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;47&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;6729&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Pts with a history of constipation&#44; <span class="elsevierStyleItalic">N</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;23&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;25&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;16&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;9999&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Pts undergoing long-term NIV&#44; <span class="elsevierStyleItalic">N</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;45&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;47&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;6729&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Pts previously administered PEG&#44; <span class="elsevierStyleItalic">N</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;14&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;13&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;16&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;9999&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>FVC &#40;L&#41;&#44; median &#40;range&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;86 &#40;0&#46;11&#8211;1&#46;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;85 &#40;0&#46;11&#8211;1&#46;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;96 &#40;0&#46;30&#8211;1&#46;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8967&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>FVC &#40;&#37;&#41;&#44; median &#40;range&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;0 &#40;3&#46;0&#8211;96&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;0 &#40;3&#46;0&#8211;96&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#46;0 &#40;9&#46;0&#8211;32&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;9501&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>MIP &#40;cm H<span class="elsevierStyleInf">2</span>O&#41;&#44; median &#40;range&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;8&#8211;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;8&#8211;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>MEP &#40;cm H<span class="elsevierStyleInf">2</span>O&#41;&#44; median &#40;range&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;4&#8211;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;4&#8211;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Clinical&#44; laboratory and blood gas data at RICU admission</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Heart rate &#40;beats&#47;min&#41;&#44; median &#40;range&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">108&#46;5 &#40;45&#46;0&#8211;134&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">104&#46;0 &#40;45&#46;0&#8211;112&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">123&#46;0 &#40;120&#46;0&#8211;134&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0095&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Respiratory rate &#40;breaths&#47;min&#41;&#44; median &#40;range&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#46;0 &#40;12&#46;0&#8211;18&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#46;0 &#40;12&#46;0&#8211;18&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#46;0 &#40;12&#46;0&#8211;16&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8390&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Pts with fever&#44; <span class="elsevierStyleItalic">N</span> &#40;&#37;&#41; &#40;Temperature<span class="elsevierStyleHsp" style=""></span>&#62;38<span class="elsevierStyleHsp" style=""></span>&#176;C&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;7&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;8&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;9999&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Total WBC count &#40;&#215;10<span class="elsevierStyleSup">9</span>&#47;L&#41;&#44; median &#40;range&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;82 &#40;2&#46;06&#8211;18&#46;02&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;65 &#40;2&#46;06&#8211;18&#46;02&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;2 &#40;11&#46;06&#8211;17&#46;80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0113&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Pts with abnormal CRP or ESR level&#44; <span class="elsevierStyleItalic">N</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;35&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;38&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;16&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;5085&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>PaO<span class="elsevierStyleInf">2</span><a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a> &#40;mmHg&#41;&#44; median &#40;range&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
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                          "etal" => true
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                            3 => "K&#46;A&#46; James"
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Vol. 57. Issue 10.
Pages 666-668 (October 2021)
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Vol. 57. Issue 10.
Pages 666-668 (October 2021)
Scientific Letter
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Non-Invasive Ventilation for Acute Respiratory Failure in Duchenne Muscular Dystrophy Patients
Ventilación no invasiva para la insuficiencia respiratoria aguda en pacientes con distrofia muscular de Duchenne
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Andrea Vianelloa,
Corresponding author
andrea.vianello@aopd.veneto.it

Corresponding author.
, Giovanna Arcaroa, Gabriella Guarnieria, Andi Sukthia, Beatrice Molenaa, Cristian Turatob, Fausto Braccionia, Federico Gallana, Francesca Lugatoa, Martina Turrina, Luca Belloc, Paolo Navalesid
a Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy
b Department of Molecular Medicine, University of Pavia, Pavia, Italy
c Department of Neurosciences DNS University of Padova, Padova, Italy
d Department of Medicine DIMED, University of Padova, Padova, Italy
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Tables (1)
Table 1. Patients’ baseline demographic, clinical, and cardio-pulmonary function characteristics, and clinical, laboratory and blood gas data at RICU admission.
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Dear Editor:

Duchenne Muscular Dystrophy (DMD) is the most common inherited muscle disease in children, with a prevalence ranging between 1.3 and 2.1 per 10,000 live male births.1 Acute Respiratory Failure (ARF) is a common complication in individuals with DMD and a primary cause of mortality, both in the teenage and adult years.2

Non-Invasive Ventilation (NIV) is a ventilatory technique for delivering pressurized gas to the lungs through a sealed mask that can be placed over the mouth, nose or the whole face; its utilization is recommended for the management of ARF across a variety of aetiologies. However, NIV application in exacerbated DMD patients is still controversial and not indicated by major guidelines.3, The aim of our study was to evaluate clinical status and outcomes in DMD patients being administered NIV for ARF.

We collected and reviewed all of the medical records of the DMD patients with ARF who were admitted to our adult 4 bed Respiratory ICU (RICU) at the University of Padua Medical Center between January 1, 2005 and December 31, 2019. Ethical approval was waived by the local Ethics Committee in view of the fact that the study was retrospective and not prepared according to a research project.

At the time of admission to the RICU, the clinical and physiologic parameters of these patients were consistent with ARF. In particular, each of them presented at least one of the following: (1) respiratory distress; (2) hypoxemia and/or hypercapnia; (3) acute respiratory acidosis.4 Patients who had received NIV as first-line ventilatory treatment were included in the study; those who had a tracheostomy tube in place or showed an immediate need for Endotracheal Intubation (ETI)5 were excluded.

All hospital charts were reviewed for patients’ baseline clinical, demographic and pulmonary function data after informed consent release forms were obtained. Clinical, laboratory and blood gas data at RICU admission were also recorded and analyzed.

Causes of ARF were classified as: upper respiratory tract infection (URTI); acute decompensated heart failure (ADHF); pneumonia; and other (e.g., pneumothorax, pulmonary thromboembolism, dysphagia with aspiration, gastroparesis/malnutrition, acute gastrointestinal distension, abuse of sedatives). The diagnosis of URTI was based on the presence of one or more of the following symptoms or signs: fever, throat irritation or sore throat, hoarseness6; the diagnoses of pneumonia and/or ADHF were based on major guidelines.7,8

The decision to begin NIV was usually made by the attending physician, according to the hospital internal protocol.9 NIV was usually delivered using a portable ventilator set in assisted pressure-control ventilation (APCV) mode. A commercial full-face mask was used when NIV was initiated and in some cases it was substituted by a nasal mask after the first hours of ventilation. In the event of NIV failure, the patients were shifted from NIV to Invasive Mechanical Ventilation (IMV) by ETI unless they had previously declared that they did not wish to be intubated. Mechanical In-Exsufflation (MI-E) was usually administered to those patients showing bronchial mucous encumbrance and oxyhemoglobin desaturation secondary to secretion retention, according to the hospital internal protocol.6

The patients were divided into 2 groups depending on their NIV response. “NIV success group” was made up of those individuals who avoided ETI, were discharged from RICU and survived for at least 48h after being transferred to the respiratory ward. “NIV failure group” was made up of those subjects who required ETI or died while on NIV support.

During the study period, 51 patients were admitted to our RICU for ARF with a primary diagnosis of DMD. Seven (13.7%) had a tracheostomy tube in place and were administered IMV via tracheal cannula, 2 (3.9%) were intubated at admission, while all the remaining 42 (82.3%), received NIV as the first-line ventilatory intervention and were considered eligible to participate in our retrospective study. No patient experienced repeated episodes of ARF. Of notice, RICU admissions were evenly distributed during the study period. Baseline demographic, clinical, pulmonary and cardiac function, of the patients are outlined in Table 1. Conditions associated with the onset of ARF in the patients studied included URTI (19 cases); ADHF (5 cases); pneumonia (4 cases); and other conditions (14 cases). The patients were administered NIV in APCV. The initial inspiratory pressure above PEEP was 12 (8–25) cmH2O. All subjects were fully cooperative during NIV and did not require any sedation. NIV was successful in 36 patients (85.7%), while unsuccessful in the remaining 6 (14.3%). The median time from NIV initiation to intubation was 3.5 (1–11) days. Among patients who failed NIV, the cause of ARF was dysphagia with aspiration in 3 cases; ADHF in 2 cases; and pneumonia in 1 case. Causes of NIV failure were failure to adequately correct hypercapnia and exhaustion (3 cases), persistent accumulation of bronchial secretions (2 cases), and severe hemodynamic instability (1 case). Two patients died following intubation while on IMV support; the remaining four required tracheostomy due to difficult weaning and underwent long-term invasive ventilation. No major NIV complication was observed, while minor complications occurred in 4 patients (nasal skin lesions in 3 cases and acute bowel distension in 1 case). All 36 patients successfully treated and 4 out of 6 who failed NIV were discharged alive from hospital. Patients’ characteristics at RICU admission are outlined in Table 1. The median survival of the 42 NIV patients after RICU admission was 67.1 (95%CI, 15.0 to 125.4) days. Survival was significantly reduced for patients who failed NIV, compared to those who succeeded [median survival time: 11.7 (95%CI, 0.0 to 131.0) vs 85.9 (95%CI, 24.9 to 125.4) days], with an HR of dying of 3.91 (95%CI, 1.10 to 13.93; p=0.0351). None of the covariates had a significant effect on NIV failure. However, patients who did not respond to NIV were younger than those who succeeded [15 (14–30) vs. 24.5 (14–41) yrs; p=0.0201]; moreover, patients’ characteristics at RICU admission showed greater HR values [123.0 (120.0–134.0) vs. 104.0 (45.0–112.0) b/min; p=0.0095], total WBC count [13.2 (11.06–17.80) vs. 8.65 (2.06–18.02); p=0.0113] and SaO2 [98 (94.8–99.2) vs. 95.1 (88.9–99); p=0.011] for failures, as opposed to successes (Table 1).

Table 1.

Patients’ baseline demographic, clinical, and cardio-pulmonary function characteristics, and clinical, laboratory and blood gas data at RICU admission.

  All cases  NIV succes group  NIV failure group  p-Value 
Baseline demographic, clinical and cardio-pulmonary function data
Number of subjects  42  36 (85.7%)  6 (14.3%)  NA 
Age (years), median (range)  23.5 (2–41)  24.5 (14–41)  15 (14–30)  0.0201 
BMI (kg/m2), median (range)  21.1 (9.5–35.2)  21.1 (9.5–35.2)  20.7 (14.7–28.5)  0.9615 
Age at DMD diagnosis (years), median (range)  5 (0.3–11)  5 (0.3–11.0)  0.7 (0.7–0.7)  0.1932 
Pts with scoliosis, N (%)  37 (88.1)  33 (91.7)  4 (66.7)  0.1414 
Pts with cardiomyopathy, N (%)  19 (45.2)  17 (47.2)  2 (33.3)  0.6729 
Pts with a history of constipation, N (%)  10 (23.8)  9 (25.0)  1 (16.7)  0.9999 
Pts undergoing long-term NIV, N (%)  19 (45.2)  17 (47.2)  2 (33.3)  0.6729 
Pts previously administered PEG, N (%)  6 (14.3)  5 (13.9)  1 (16.7)  0.9999 
FVC (L), median (range)  0.86 (0.11–1.98)  0.85 (0.11–1.98)  0.96 (0.30–1.47)  0.8967 
FVC (%), median (range)  16.0 (3.0–96.0)  15.0 (3.0–96.0)  22.0 (9.0–32.0)  0.9501 
MIP (cm H2O), median (range)  23 (8–37)  23 (8–37)  –  NA 
MEP (cm H2O), median (range)  20 (4–30)  20 (4–30)  –  NA 
Clinical, laboratory and blood gas data at RICU admission
Heart rate (beats/min), median (range)  108.5 (45.0–134.0)  104.0 (45.0–112.0)  123.0 (120.0–134.0)  0.0095 
Respiratory rate (breaths/min), median (range)  14.0 (12.0–18.0)  14.0 (12.0–18.0)  14.0 (12.0–16.0)  0.8390 
Pts with fever, N (%) (Temperature>38°C)  3 (7.1)  3 (8.3)  0 (0.0)  0.9999 
Total WBC count (×109/L), median (range)  8.82 (2.06–18.02)  8.65 (2.06–18.02)  13.2 (11.06–17.80)  0.0113 
Pts with abnormal CRP or ESR level, N (%)  15 (35.7)  14 (38.9)  1 (16.7)  0.5085 
PaO2* (mmHg), median (range)  71.6 (33.8–175)  70.6 (43.1–105.8)  92.8 (33.8–175)  0.2123 
PaCO2 (mmHg), median (range)  44.7 (31.6–96.1)  44.6 (32–78)  52.8 (31.6–96.1)  0.5949 
Arterial pH, median (range)  7.4 (7.3–7.6)  7.4 (7.3–7.6)  7.4 (7.3–7.5)  0.8698 
SaO2 (%), median (range)  95.5 (88.9–99.2)  95.1 (88.9–99)  98 (94.8–99.2)  0.0110 
Pts with abnormal BNP or NT-proBNP level, N (%)  13 (30.9)  12 (33.3)  1 (16.7)  0.6468 
Pts with hypokalemia, N (%)  12 (28.6)  10 (27.7)  2 (33.3)  0.9999 

BMI=Body Mass Index; BNP=Brain Natriuretic Peptide; CRP=C-Reactive Protein; DMD=Duchenne Muscular Dystrophy; ESR=Erythrocyte Sedimentation Rate; FVC=Forced Vital Capacity; MEP=Maximal Expiratory Pressure; MIP=Maximal Inspiratory Pressure; NA=not applicable; NIV=Non-Invasive Ventilation; NT-proBNP=N-terminal prohormone of Brain Natriuretic Peptide; PEG=Percutaneous gastrostomy; RICU=Respiratory Intensive Care Unit; SaO2=arterial oxygen saturation; WBC=White Blood Cell).

p-Values refer to differences between NIV success and NIV failure groups.

*

During supplemental oxygen therapy.

The use of NIV in DMD patients for ARF is still debated.10–12 In our study, the overall success rate of 86% corroborates the positive role of NIV in avoiding tracheal intubation. On our opinion, high success rate of NIV treatment in our patients can be explained by several factors, including the following. First, we used APCV, a mode of partial ventilatory support found to be comfortable and minimally affected by patient–ventilator asynchrony in individuals with ventilatory failure of neuromuscular origin.13 Second, we chose full-face mask as first choice. Indeed, nasal masks may be problematic in these patients because of weakness of masseter muscles, causing incomplete jaw closing and major mouth air leaks. Furthermore, patients with ARF are characterized by mouth-breathing making nasal masks ineffective. For these reasons, despite a potentially increased risk of gastric distension and emesis into the mask,14 a full face mask was preferred in our patients. Third, the combined use of MI-E was effective in clearing bronchial secretions in most patients who developed bronchial mucous encumbrance and consequent oxyhemoglobin desaturation, in keeping with previous data both in adults and children with NMD.15 Finally, it is worth remarking that our team of pulmonary physicians and nurses has been involved in NIV treatment of NMD patients with ARF for over 20 years.

Notwithstanding the low NIV failure rate, we believe that appropriate selection criteria for attempting NIV in this setting is a crucial unresolved issue. Unfortunately, we found none of the covariates associated with NIV failure. Noteworthy, patients who did not respond to NIV were younger than those who succeeded and reported dysphagia, weight loss and aspiration in 3 out of 6 cases. Swallowing disturbances resulting in increased risk of inhalation have been reported as a possible mechanism of ARF in boys with DMD16 and a common cause of NIV failure in NMD patients.9

Of interest, there was a trend toward higher PaO2, SaO2, and PaCO2 values in the NIV failure compared to NIV success group. We hypothesize that delivery of excessively high amounts of supplemental oxygen during transfer to our RICU might have increased the risk of NIV failure, by depressing spontaneous ventilation. Indeed, oxygen therapy has been shown to reduce the drive to breathe and lead to CO2 retention in DMD patients during respiratory exacerbations.17

Our study has important limitations, being single-centered, retrospective and observational. It is important to remind, however, that prospective randomized trials in this patient population are unlikely to be performed because of the limited number of patients affected with DMD and of possible ethical issues. The study's long time span is also a potential weakness. Worth mentioning, however, we did not make significant changes in pharmacologic therapy and/or supportive care during the study period.

Despite these major limitations, our study indicates NIV to be a viable option in DMD patients showing signs of ARF as it can effectively reverse ARF in the majority of patients, with the caveat that its use should be extremely careful in younger patients with dysphagia.

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