Morfologia de la curva dosis-respuesta a la metacolina: diferencias entre sujetos asmaticos y normales

Pellicer Ciscar, C.; Perpiña Tordera, M.; Jorquera Nieto, J.I.; Marco Martinez, V.

doi:10.1016/S0300-2896(15)31963-3

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"apellidos" => "Olcoz Monreal" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615319621?idApp=UINPBA00003Z" "url" => "/03002896/0000002300000003/v1_201509151053/S0300289615319621/v1_201509151053/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Morfologia de la curva dosis-respuesta a la metacolina: diferencias entre sujetos asmaticos y normales" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "128" "paginaFinal" => "132" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "C. Pellicer Ciscar, M. Perpiña Tordera, J.I. Jorquera Nieto, V. Marco Martinez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Pellicer Ciscar" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Perpiña Tordera" ] 2 => array:2 [ "nombre" => "J.I." "apellidos" => "Jorquera Nieto" ] 3 => array:2 [ "nombre" => "V." "apellidos" => "Marco Martinez" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Neumología. Hospital La Fe. Valencia" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The shape of the dose-response curve to methacholine: differences between asthmatic and healthy subjects" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1986-05-15" "fechaAceptado" => "1986-11-03" "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "El objetivo del presente estudio ha sido analizar la morfología y posición de las curvas dosis-respuesta (CDR) a la metacolina. Con este motivo, hemos construido en 17 sujetos con asma leve y 10 sujetos normales, CDR completas a metacolina, buscando su mejor adaptación a las funciones matemáticas: linear, semilogarítmica, potencial y sigmoidea. En ambos grupos, el coeficiente de correlación más alto se obtuvo para la morfología sigmoidea, sin embargo, la posición de estas curvas en el eje de coordenadas fue distinta. El estudio de los diversos factores que determinan las diferencias existentes en las CDR entre sujetos normales y asmáticos, puede contribuir al mejor conocimiento de la patogenia de la hiperreactividad bronquial." ] "en" => array:1 [ "resumen" => "The aim of this study was to analyze the shape and position of the dose-response curves (CDR) to methacholine.Complete dose-response curves to methacholine were built for 17 mild asthmatic and 10 healthy subjects, looking for the best possible fitting to one of the following mathematical models: lineal, semilogarythmic, potential and sigmoid. The highest correlation coefficient was obtained for sigmoid model in both groups. The curves showed however different positions when plotted in coordinate axis. The study of the several factors responsible for the differences of CDRs between asthmatic and healthy subjects may contribute to a better insight in the pathogenesis of bronchial hyperreactivity." ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:25 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Les tests de provocation bronchique non-spècifiques dans l’asthme" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Orehek" 1 => "P. Gayrard" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Bull Europ Physiopath Resp" "fecha" => "1976" "volumen" => "12" "paginaInicial" => "565" "paginaFinal" => "598" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." 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Archivos de Bronconeumología

ISSN: 0300-2896

Archivos de Bronconeumologia is an international journal that publishes original studies whose content is based upon results of research initiatives dealing with several aspects of respiratory medicine including epidemiology, respiratory physiology, pathophysiology of respiratory diseases, clinical management, thoracic surgery, pediatric lung diseases, respiratory critical care, respiratory allergy and basic research. Other types of articles such as editorials, reviews, and different types of letters are also published in the journal. Additionally, the journal expresses the voice of the following scientific societies: the Spanish Respiratory Society of Pneumology and Thoracic Surgery (SEPAR; https://www.separ.es/), the Latin American Thoracic Society (ALAT; https://alatorax.org/), and the Iberian American Association of Thoracic Surgery (AIACT; http://www.aiatorax.com/).

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Vol. 23. Issue 3.

Pages 128-132 (May - June 1987)

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Pages 128-132 (May - June 1987)

DOI: 10.1016/S0300-2896(15)31963-3

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Morfologia de la curva dosis-respuesta a la metacolina: diferencias entre sujetos asmaticos y normales

The shape of the dose-response curve to methacholine: differences between asthmatic and healthy subjects

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C. Pellicer Ciscar, M. Perpiña Tordera, J.I. Jorquera Nieto, V. Marco Martinez

Servicio de Neumología. Hospital La Fe. Valencia

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El objetivo del presente estudio ha sido analizar la morfología y posición de las curvas dosis-respuesta (CDR) a la metacolina. Con este motivo, hemos construido en 17 sujetos con asma leve y 10 sujetos normales, CDR completas a metacolina, buscando su mejor adaptación a las funciones matemáticas: linear, semilogarítmica, potencial y sigmoidea. En ambos grupos, el coeficiente de correlación más alto se obtuvo para la morfología sigmoidea, sin embargo, la posición de estas curvas en el eje de coordenadas fue distinta. El estudio de los diversos factores que determinan las diferencias existentes en las CDR entre sujetos normales y asmáticos, puede contribuir al mejor conocimiento de la patogenia de la hiperreactividad bronquial.

The aim of this study was to analyze the shape and position of the dose-response curves (CDR) to methacholine.

Complete dose-response curves to methacholine were built for 17 mild asthmatic and 10 healthy subjects, looking for the best possible fitting to one of the following mathematical models: lineal, semilogarythmic, potential and sigmoid. The highest correlation coefficient was obtained for sigmoid model in both groups. The curves showed however different positions when plotted in coordinate axis. The study of the several factors responsible for the differences of CDRs between asthmatic and healthy subjects may contribute to a better insight in the pathogenesis of bronchial hyperreactivity.

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