Morfologia de la curva dosis-respuesta a la metacolina: diferencias entre sujetos asmaticos y normales
The shape of the dose-response curve to methacholine: differences between asthmatic and healthy subjects
C. Pellicer Ciscar, M. Perpiña Tordera, J.I. Jorquera Nieto, V. Marco Martinez
Servicio de Neumología. Hospital La Fe. Valencia
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Dificultades en el diagnostico radiologico" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "123" "paginaFinal" => "127" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Overlapping of tuberculosis and bronchogenic carcinoma. <span class="elsevierStyleSmallCaps">X</span>-ray diagnostic difficulties" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.F. Martinez Cantarero, A. Sanchez Nistal, F.J. Olcoz Monreal" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J.F." "apellidos" => "Martinez Cantarero" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Sanchez Nistal" ] 2 => array:2 [ "nombre" => "F.J." "apellidos" => "Olcoz Monreal" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615319621?idApp=UINPBA00003Z" "url" => "/03002896/0000002300000003/v1_201509151053/S0300289615319621/v1_201509151053/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Morfologia de la curva dosis-respuesta a la metacolina: diferencias entre sujetos asmaticos y normales" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "128" "paginaFinal" => "132" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "C. Pellicer Ciscar, M. Perpiña Tordera, J.I. Jorquera Nieto, V. Marco Martinez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Pellicer Ciscar" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Perpiña Tordera" ] 2 => array:2 [ "nombre" => "J.I." "apellidos" => "Jorquera Nieto" ] 3 => array:2 [ "nombre" => "V." "apellidos" => "Marco Martinez" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Neumología. Hospital La Fe. Valencia" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The shape of the dose-response curve to methacholine: differences between asthmatic and healthy subjects" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1986-05-15" "fechaAceptado" => "1986-11-03" "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El objetivo del presente estudio ha sido analizar la morfología y posición de las curvas dosis-respuesta (CDR) a la metacolina. Con este motivo, hemos construido en 17 sujetos con asma leve y 10 sujetos normales, CDR completas a metacolina, buscando su mejor adaptación a las funciones matemáticas: linear, semilogarítmica, potencial y sigmoidea. En ambos grupos, el coeficiente de correlación más alto se obtuvo para la morfología sigmoidea, sin embargo, la posición de estas curvas en el eje de coordenadas fue distinta. El estudio de los diversos factores que determinan las diferencias existentes en las CDR entre sujetos normales y asmáticos, puede contribuir al mejor conocimiento de la patogenia de la hiperreactividad bronquial.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to analyze the shape and position of the dose-response curves (CDR) to methacholine.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Complete dose-response curves to methacholine were built for 17 mild asthmatic and 10 healthy subjects, looking for the best possible fitting to one of the following mathematical models: lineal, semilogarythmic, potential and sigmoid. The highest correlation coefficient was obtained for sigmoid model in both groups. The curves showed however different positions when plotted in coordinate axis. The study of the several factors responsible for the differences of CDRs between asthmatic and healthy subjects may contribute to a better insight in the pathogenesis of bronchial hyperreactivity.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:25 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Les tests de provocation bronchique non-spècifiques dans l’asthme" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Orehek" 1 => "P. Gayrard" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Bull Europ Physiopath Resp" "fecha" => "1976" "volumen" => "12" "paginaInicial" => "565" "paginaFinal" => "598" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 3 | 7 |
| 2024 October | 43 | 33 | 76 |
| 2024 September | 32 | 45 | 77 |
| 2024 August | 45 | 38 | 83 |
| 2024 July | 29 | 31 | 60 |
| 2024 June | 36 | 20 | 56 |
| 2024 May | 43 | 51 | 94 |
| 2024 April | 30 | 25 | 55 |
| 2024 March | 41 | 38 | 79 |
| 2024 February | 31 | 50 | 81 |
| 2024 January | 0 | 15 | 15 |
| 2023 December | 0 | 6 | 6 |
| 2023 November | 0 | 11 | 11 |
| 2023 October | 0 | 7 | 7 |
| 2023 September | 0 | 9 | 9 |
| 2023 August | 0 | 4 | 4 |
| 2023 July | 0 | 24 | 24 |
| 2023 June | 0 | 8 | 8 |
| 2023 May | 0 | 3 | 3 |
| 2023 April | 0 | 3 | 3 |
| 2023 March | 3 | 6 | 9 |
| 2023 February | 29 | 13 | 42 |
| 2023 January | 20 | 25 | 45 |
| 2022 December | 34 | 32 | 66 |
| 2022 November | 35 | 26 | 61 |
| 2022 October | 23 | 39 | 62 |
| 2022 September | 19 | 19 | 38 |
| 2022 August | 34 | 54 | 88 |
| 2022 July | 23 | 33 | 56 |
| 2022 June | 48 | 35 | 83 |
| 2022 May | 48 | 23 | 71 |
| 2022 April | 26 | 25 | 51 |
| 2022 March | 41 | 31 | 72 |
| 2022 February | 38 | 25 | 63 |
| 2022 January | 39 | 16 | 55 |
| 2021 December | 16 | 27 | 43 |
| 2021 November | 21 | 35 | 56 |
| 2021 October | 20 | 38 | 58 |
| 2021 September | 21 | 23 | 44 |
| 2021 August | 11 | 18 | 29 |
| 2021 July | 15 | 17 | 32 |
| 2021 June | 15 | 25 | 40 |
| 2021 May | 23 | 24 | 47 |
| 2021 April | 37 | 47 | 84 |
| 2021 March | 29 | 24 | 53 |
| 2021 February | 24 | 10 | 34 |
| 2021 January | 22 | 16 | 38 |
| 2020 December | 20 | 13 | 33 |
| 2020 November | 22 | 23 | 45 |
| 2020 October | 22 | 26 | 48 |
| 2020 September | 20 | 14 | 34 |
| 2020 August | 17 | 15 | 32 |
| 2020 July | 9 | 11 | 20 |
| 2020 June | 15 | 18 | 33 |
| 2020 May | 18 | 16 | 34 |
| 2020 April | 25 | 10 | 35 |
| 2020 March | 18 | 17 | 35 |
| 2020 February | 15 | 29 | 44 |
| 2020 January | 25 | 35 | 60 |
| 2019 December | 28 | 45 | 73 |
| 2019 November | 8 | 24 | 32 |
| 2019 October | 11 | 33 | 44 |
| 2019 September | 11 | 34 | 45 |
| 2019 August | 13 | 14 | 27 |
| 2019 July | 14 | 21 | 35 |
| 2019 June | 13 | 19 | 32 |
| 2019 May | 20 | 31 | 51 |
| 2019 April | 22 | 19 | 41 |
| 2019 March | 8 | 15 | 23 |
| 2019 February | 7 | 14 | 21 |
| 2019 January | 9 | 9 | 18 |
| 2018 December | 7 | 18 | 25 |
| 2018 November | 7 | 16 | 23 |
| 2018 October | 20 | 24 | 44 |
| 2018 September | 14 | 9 | 23 |
| 2018 May | 8 | 5 | 13 |
| 2018 April | 8 | 14 | 22 |
| 2018 March | 5 | 14 | 19 |
| 2018 February | 7 | 14 | 21 |
| 2018 January | 9 | 8 | 17 |
| 2017 December | 12 | 13 | 25 |
| 2017 November | 8 | 12 | 20 |
| 2017 October | 11 | 12 | 23 |
| 2017 September | 7 | 7 | 14 |
| 2017 August | 6 | 16 | 22 |
| 2017 July | 5 | 10 | 15 |
| 2017 June | 11 | 24 | 35 |
| 2017 May | 13 | 21 | 34 |
| 2017 April | 9 | 13 | 22 |
| 2017 March | 6 | 14 | 20 |
| 2017 February | 2 | 5 | 7 |
| 2017 January | 3 | 16 | 19 |
| 2016 December | 5 | 9 | 14 |
| 2016 November | 12 | 13 | 25 |
| 2016 October | 14 | 18 | 32 |
| 2016 September | 22 | 13 | 35 |
| 2016 August | 12 | 6 | 18 |
| 2016 July | 21 | 4 | 25 |
| 2016 June | 16 | 9 | 25 |
| 2016 May | 12 | 3 | 15 |
| 2016 April | 18 | 0 | 18 |
| 2016 March | 18 | 0 | 18 |
| 2016 February | 11 | 0 | 11 |
| 2016 January | 16 | 7 | 23 |
| 2015 December | 25 | 11 | 36 |
| 2015 November | 30 | 7 | 37 |
| 2015 October | 7 | 1 | 8 |
| 2015 September | 2 | 0 | 2 |
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