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Vol. 11. Issue 4.
Pages 134-136 (October - December 1975)
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Vol. 11. Issue 4.
Pages 134-136 (October - December 1975)
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Minociclina en el tratamiento de infecciones respiratorias
Minocycline in the treatment of respiratory infections
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C. Lozano, M. Gobernado, V. Bonora, M. Santos, J.L. Sanchis, N. Diosdado, J. Báguena
Servicios de Neumología, Dpto. Med. Interna y Microbiología Ciudad Sanitaria La Fe, Valencia
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Resumen

Una tetraciclina, minociclina, fue adeministrada por vía oral a cuarenta enfermos con infección del aparato respiratorio. La dosis fue de 300mg el primer día y 200mg los restantes, durante un promedio de 9 días. La respuesta clínica fue buena en el 77% d los casos y la bacteriológica en el 55%. Los efectos secundarios y tóxicos fueron mínimos.

Summary

A tetracycline, minocycline, was administered by oral route to 40 patients with infections of the respiratory apparatus. The dosage was 300mg. The first day and 200mg. the following days for an average of 9 days. The clinical response was good in 77% of the cases and the bacteriological response was good in 55% of the cases. The secondary and toxic effects were minimum.

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Bibliografia
[1.]
G.S. Redin.
Antibacterial activity in mice of minocycline, a new tetracycline.
Antimicrob. Agents and Chemother, 196 (1967), pp. 371
[2.]
M.J. Martell, J.H. Boothe.
The 6-deoxytetracyclines VII Alkylated aminotetracyclines possesing unique antibacterial activity.
J. Med. Chem, 10 (1967), pp. 44
[3.]
J.F. Noble, L.A. Kanegis, D.W. Hallesy.
Short-term toxicity and oblservations on certain aspects of the pharmacology of a unique tetracycline-minocycline.
Toxicol. Appl. Pharmacol, 11 (1967), pp. 128
[4.]
N.H. Steigbigel, C.N. Reed, M. Finland.
Absortion and excretion of five tetracyclines analogues in normal young men.
Am. J. Med. Sci, 225 (1968), pp. 296
[5.]
G. Renzini, R.L. Bevilacqua, G. Boemi, L. Ravagnan.
Activity antibalterica in vitro e in vivo di una nueva tetraciclina: CL 59806.
Antibiótica, 5 (1967), pp. 241
[6.]
K.F. Benitz, G.K.S. Roberts, A. Yusa.
Morphologic effects of minocycline in laboratory animals.
Toxicol. Appl. Pharmacol, 11 (1967), pp. 150
[7.]
A.R. Frisk, C. Tunevall.
Clinical Evaluation of Minocycline.
Antimicrcb. Agents and Chemother., 335 (1969), pp. 8
[8.]
N.H. Steigbigel, C.N. Reed, M. Finland.
Susceptibility of Common Pathogenic Bacteria to Seven Tetracycline Antibiotics in vitro.
Amer. J. Med. Sci, 255 (1968), pp. 179
[9.]
J. Fedorko, S. Katz, H. Allnoch.
In vitro activity of Minocycline, a new Tetracycline.
Am. J. Med. Sci, 225 (1968), pp. 4
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