Minociclina en el tratamiento de infecciones respiratorias
Minocycline in the treatment of respiratory infections
C. Lozano, M. Gobernado, V. Bonora, M. Santos, J.L. Sanchis, N. Diosdado, J. Báguena
Servicios de Neumología, Dpto. Med. Interna y Microbiología Ciudad Sanitaria La Fe, Valencia
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Martínez González del Río, J. Pérez Guerrero, F. Lahoz Navarro, A. Sastre Castillo, F. Marín Núñez, E. Alvarez Cuesta, A. López Encuentra, M. Lorenzo Cruz" "autores" => array:8 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Martínez González del Río" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Pérez Guerrero" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Lahoz Navarro" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Sastre Castillo" ] 4 => array:2 [ "nombre" => "F." "apellidos" => "Marín Núñez" ] 5 => array:2 [ "nombre" => "E." "apellidos" => "Alvarez Cuesta" ] 6 => array:2 [ "nombre" => "A." "apellidos" => "López Encuentra" ] 7 => array:2 [ "nombre" => "M." "apellidos" => "Lorenzo Cruz" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028961532768X?idApp=UINPBA00003Z" "url" => "/03002896/0000001100000004/v1_201509151309/S030028961532768X/v1_201509151309/es/main.assets" ] "es" => array:11 [ "idiomaDefecto" => true "titulo" => "Minociclina en el tratamiento de infecciones respiratorias" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "134" "paginaFinal" => "136" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "C. Lozano, M. Gobernado, V. Bonora, M. Santos, J.L. Sanchis, N. Diosdado, J. Báguena" "autores" => array:7 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Lozano" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Gobernado" ] 2 => array:2 [ "nombre" => "V." "apellidos" => "Bonora" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Santos" ] 4 => array:2 [ "nombre" => "J.L." "apellidos" => "Sanchis" ] 5 => array:2 [ "nombre" => "N." "apellidos" => "Diosdado" ] 6 => array:2 [ "nombre" => "J." "apellidos" => "Báguena" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicios de Neumología, Dpto. Med. Interna y Microbiología Ciudad Sanitaria La Fe, Valencia" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Minocycline in the treatment of respiratory infections" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Una tetraciclina, minociclina, fue adeministrada por vía oral a cuarenta enfermos con infección del aparato respiratorio. La dosis fue de 300<span class="elsevierStyleHsp" style=""></span>mg el primer día y 200<span class="elsevierStyleHsp" style=""></span>mg los restantes, durante un promedio de 9 días. La respuesta clínica fue buena en el 77% d los casos y la bacteriológica en el 55%. Los efectos secundarios y tóxicos fueron mínimos.</p></span>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A tetracycline, minocycline, was administered by oral route to 40 patients with infections of the respiratory apparatus. The dosage was 300<span class="elsevierStyleHsp" style=""></span>mg. The first day and 200<span class="elsevierStyleHsp" style=""></span>mg. the following days for an average of 9 days. The clinical response was good in 77% of the cases and the bacteriological response was good in 55% of the cases. The secondary and toxic effects were minimum.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antibacterial activity in mice of minocycline, a new tetracycline" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.S. Redin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Antimicrob. Agents and Chemother" "fecha" => "1967" "volumen" => "196" "paginaInicial" => "371" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." 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