Measurement of Fraction of Exhaled Nitric Oxide With the Portable NIOX-MINO Monitor in Healthy Adult

Fortuna, Ana María; Feixas, Teresa; Casan, Pere

doi:10.1016/S1579-2129(07)60044-5

Archivos de Bronconeumología

ISSN: 0300-2896

Archivos de Bronconeumologia is an international journal that publishes original studies whose content is based upon results of research initiatives dealing with several aspects of respiratory medicine including epidemiology, respiratory physiology, pathophysiology of respiratory diseases, clinical management, thoracic surgery, pediatric lung diseases, respiratory critical care, respiratory allergy and basic research. Other types of articles such as editorials, reviews, and different types of letters are also published in the journal. Additionally, the journal expresses the voice of the following scientific societies: the Spanish Respiratory Society of Pneumology and Thoracic Surgery (SEPAR; https://www.separ.es/), the Latin American Thoracic Society (ALAT; https://alatorax.org/), and the Iberian American Association of Thoracic Surgery (AIACT; http://www.aiatorax.com/).

It is a monthly journal in which all manuscripts are sent to peer-review and handled by the editor or an associate editor from the team and the final decision is made on the basis of the comments from the expert reviewers and the editors. The journal is published solely in English. All the published data is composed of novel manuscripts not previously published in any other journal and not being in consideration for publication in any other journal..

The journal is indexed at Science Citation Index Expanded, Medline/Pubmed, Embase and SCOPUS. Access to any published article is possible through the journal's web page as well as from Pubmed, ScienceDirect, and other international databases. Furthermore, the journal is also present in X, Facebook and Linkedin. Manuscripts can be submitted electronically using the following web site: https://www.editorialmanager.com/ARBR/.

Indexed in:

Current Contents/Clinical Medicine, JCR SCI-Expanded, Index Medicus/Medline, Excerpta Medica/EMBASE, IBECS, IME, SCOPUS, IBECS

Subscribe:

Impact factor

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years.

© Clarivate Analytics, Journal Citation Reports 2022

Impact factor 2023

8.7

Citescore

CiteScore measures average citations received per document published.

Citescore 2023

3.5

SJR

SRJ is a prestige metric based on the idea that not all citations are the same. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal's impact.

SJR 2023

0.464

SNIP

SNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field.

SNIP 2023

0.482

View more metrics

Open Access Option

Journal Information

Previous article | Next article

Vol. 43. Issue 3.

Pages 176-179 (January 2007)

More article options

Pages 176-179 (January 2007)

Techniques And Procedures

DOI: 10.1016/S1579-2129(07)60044-5

Full text access

Measurement of Fraction of Exhaled Nitric Oxide With the Portable NIOX-MINO Monitor in Healthy Adult

Visits

6164

Download PDF

Ana María Fortuna, Teresa Feixas, Pere Casan

Corresponding author

pcasan@hsp.santpau.es

Correspondence: Dr. P. Casan. Unidad de Función Pulmonar. Hospital de la Santa Creu i Sant Pau. St. Antoni M. Claret, 167. 08025 Barcelona. España

Unidad de Función Pulmonar, Departamento de Neumología, Hospital de la Santa Creu i Sant Pau. Facultad de Medicina, Universidad Autónoma de Barcelona, Barcelona, Spain

This item has received

6164 Visits

Article information

Statistics

Measurement of the fraction of exhaled nitric oxide (FENO) provides a noninvasive way to monitor asthma treatment in clinical practice. The aim of this study was to determine FENO reference values for measurements recorded with the portable NIOX MINO monitor in a group of healthy volunteers. We also assessed the association between values recorded by the portable monitor and the N-6008 chemiluminescence analyzer used in our pulmonary function laboratory. The FENO values obtained with the portable monitor were consistently higher than those recorded by the N-6008 monitor; the cutoff value for the portable monitor was 34 ppb (mean + 2 SD). We detected a direct correlation (r=0.92) between the FENO measurements recorded by the 2 monitors (P=.001). The following equation expresses the relationship between measurements from the 2 devices: FENO(NIOX-MINO) = 10 + [1.5 FENO(N-6008)]. We did not observe statistically significant correlations between FENO measurements and age, sex, body mass index, or spirometry.

Key words:

Fraction of exhaled nitric oxide

Asthma

Inflammation

La determinación de óxido nítrico en aire espirado (FENO) es una técnica no invasiva que se utiliza en la evaluación clínica y el tratamiento del asma. El objetivo de este estudio ha sido determinar los valores de referencia de FENO en un grupo de voluntarios sanos mediante la utilización de un nuevo equipo portátil (NIOX-MINO® Aerocrine), así como determinar el grado de relación que presenta con el equipo de determinación habitual en nuestro laboratorio de función pulmonar (sensor de quimioluminiscencia N-6008® SIR). Según los resultados obtenidos, los valores de FENO que da el equipo portátil son siempre superiores a los que ofrece el sensor habitual, con un valor de corte de 34 ppb (media + 2 desviación estándar). Existe un relación directa y significativa de la determinación de FENO entre ambos equipos (r = 0,92; p = 0,001) con un factor de corrección de: FENO (NIOX-MINO®) = 10 + 1,5 FENO (N-6008®). La relación entre los valores de FENO y la edad, el sexo, el índice de masa corporal y los valores espirométricos no fue estadísticamente significativa.

Palabras clave:

Óxido nítrico en aire espirado

Asma

Inflamación

Full text is only aviable in PDF

REFERENCES

[1]

Global Initiative for Asthma.

Global Strategy for Asthma Management and Prevention NHLBI/WHO Workshop Report 2002.

Available from: http://www.ginasthma.com

[2]

A Jatakanon, L Sim, S Kharitonov, K Chung, P Barnes.

Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma.

Thorax, 53 (1998), pp. 91-95

Medline

[3]

RC Strunk, SJ Szefler, B Phillips, R Zeiger, VM Chinchilli, G Larsen, et al.

Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children.

Ann Allergy Asthma Inmunol, 112 (2003), pp. 883-892

[4]

AD Smith, JO Cowan, S Filsell, C MacLachlan, G Monti-Sheedan, P Jackson, et al.

Comparisons between exhaled nitric oxide measurements and conventional tests.

Am J Respir Crit Care Med, 169 (2004), pp. 473-478

http://dx.doi.org/10.1164/rccm.200310-1376OC | Medline

[5]

A Deykin, AF Massaro, JM Drazen, E Israel.

Exhaled nitric oxide as a diagnosis test for asthma.

Am J Respir Crit Care Med, 165 (2002), pp. 1597-1601

http://dx.doi.org/10.1164/rccm.2201081 | Medline

[6]

SA Kharitonov, F Gonio, C Kelly, S Meah, PJ Barnes.

Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children.

Eur Respir J, 21 (2003), pp. 443-448

[7]

AD Smith, JO Cowan, KP Brasset, P Herbison, DR Taylor.

Use of exhaled nitric oxide measurements to guide treatment in chronic asthma.

N Engl J Med, 352 (2005), pp. 2163-2173

http://dx.doi.org/10.1056/NEJMoa043596 | Medline

[8]

JC de Jongste.

Yes to NO: the first studies on exhaled nitric oxidedriven asthma treatment.

Eur Respir J, 26 (2005), pp. 379-381

http://dx.doi.org/10.1183/09031936.05.00080705 | Medline

[9]

American Thoracic Society.

Recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide.

Am J Respir Crit Care Med, 171 (2005), pp. 912-930

http://dx.doi.org/10.1164/rccm.200406-710ST | Medline

[10]

N Calaf, JB de Lerma, T Feixas, M González, E Codina, P Casan.

Concentración de NO en el aire espirado: valores de referencia en población sana.

Arch Bronconeumol, 40 (2004), pp. 66

[11]

E Silkoff Philip, M Carlson, T Bourke, R Katial, E Ögren, SJ Szefler.

Aerocrine exhaled nitric oxide monitoring system NIOX is cleared by de US Food and Drug Administration for monitoring therapy is asthma.

J Allergy Clin Immunol, 114 (2004), pp. 1241-1256

http://dx.doi.org/10.1016/j.jaci.2004.08.042 | Medline

[12]

S Kharitonov.

NIOX-MINO®: a new handheld exhaled NO device. Proceedings, European Respiratory Society 15th Annual Congress; 2005, September 17-21; Copenhagen, European Respiratory Society, (2005),

[13]

Hemmingsson T, Linnarsson D, Gambert R. Novel hand-held device for exhaled nitric oxide analysis in research and clinical applications. Proceedings: Breath Gas Analysis for Medical Diagnosis; 2004, September 23-26; Dornbirn.