Measurement of Fraction of Exhaled Nitric Oxide With the Portable NIOX-MINO Monitor in Healthy Adult

Fortuna, Ana María; Feixas, Teresa; Casan, Pere

doi:10.1016/S1579-2129(07)60044-5

Archivos de Bronconeumología

ISSN: 0300-2896

Archivos de Bronconeumologia is an international journal that publishes original studies whose content is based upon results of research initiatives dealing with several aspects of respiratory medicine including epidemiology, respiratory physiology, pathophysiology of respiratory diseases, clinical management, thoracic surgery, pediatric lung diseases, respiratory critical care, respiratory allergy and translational research. Other types of articles such as editorials, reviews, and different types of letters are also published in the journal. Additionally, the journal expresses the voice of the following scientific societies: the Spanish Respiratory Society of Pneumology and Thoracic Surgery (SEPAR; https://www.separ.es/), the Latin American Thoracic Society (ALAT; https://alatorax.org/), and the Iberian American Association of Thoracic Surgery (AIACT; http://www.aiatorax.com/).

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Vol. 43. Issue 3.

Pages 176-179 (January 2007)

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Pages 176-179 (January 2007)

Techniques And Procedures

DOI: 10.1016/S1579-2129(07)60044-5

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Measurement of Fraction of Exhaled Nitric Oxide With the Portable NIOX-MINO Monitor in Healthy Adult

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Ana María Fortuna, Teresa Feixas, Pere Casan

Corresponding author

pcasan@hsp.santpau.es

Correspondence: Dr. P. Casan. Unidad de Función Pulmonar. Hospital de la Santa Creu i Sant Pau. St. Antoni M. Claret, 167. 08025 Barcelona. España

Unidad de Función Pulmonar, Departamento de Neumología, Hospital de la Santa Creu i Sant Pau. Facultad de Medicina, Universidad Autónoma de Barcelona, Barcelona, Spain

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Measurement of the fraction of exhaled nitric oxide (FENO) provides a noninvasive way to monitor asthma treatment in clinical practice. The aim of this study was to determine FENO reference values for measurements recorded with the portable NIOX MINO monitor in a group of healthy volunteers. We also assessed the association between values recorded by the portable monitor and the N-6008 chemiluminescence analyzer used in our pulmonary function laboratory. The FENO values obtained with the portable monitor were consistently higher than those recorded by the N-6008 monitor; the cutoff value for the portable monitor was 34 ppb (mean + 2 SD). We detected a direct correlation (r=0.92) between the FENO measurements recorded by the 2 monitors (P=.001). The following equation expresses the relationship between measurements from the 2 devices: FENO(NIOX-MINO) = 10 + [1.5 FENO(N-6008)]. We did not observe statistically significant correlations between FENO measurements and age, sex, body mass index, or spirometry.

Key words:

Fraction of exhaled nitric oxide

Asthma

Inflammation

La determinación de óxido nítrico en aire espirado (FENO) es una técnica no invasiva que se utiliza en la evaluación clínica y el tratamiento del asma. El objetivo de este estudio ha sido determinar los valores de referencia de FENO en un grupo de voluntarios sanos mediante la utilización de un nuevo equipo portátil (NIOX-MINO® Aerocrine), así como determinar el grado de relación que presenta con el equipo de determinación habitual en nuestro laboratorio de función pulmonar (sensor de quimioluminiscencia N-6008® SIR). Según los resultados obtenidos, los valores de FENO que da el equipo portátil son siempre superiores a los que ofrece el sensor habitual, con un valor de corte de 34 ppb (media + 2 desviación estándar). Existe un relación directa y significativa de la determinación de FENO entre ambos equipos (r = 0,92; p = 0,001) con un factor de corrección de: FENO (NIOX-MINO®) = 10 + 1,5 FENO (N-6008®). La relación entre los valores de FENO y la edad, el sexo, el índice de masa corporal y los valores espirométricos no fue estadísticamente significativa.

Palabras clave:

Óxido nítrico en aire espirado

Asma

Inflamación

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