Measurement of Fraction of Exhaled Nitric Oxide With the Portable NIOX-MINO Monitor in Healthy Adult

Fortuna, Ana María; Feixas, Teresa; Casan, Pere

doi:10.1016/S1579-2129(07)60044-5

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We also assessed the association between values recorded by the portable monitor and the N-6008 chemiluminescence analyzer used in our pulmonary function laboratory. The FENO values obtained with the portable monitor were consistently higher than those recorded by the N-6008 monitor; the cutoff value for the portable monitor was 34 ppb (mean + 2 SD). We detected a direct correlation (r=0.92) between the FENO measurements recorded by the 2 monitors (P=.001). The following equation expresses the relationship between measurements from the 2 devices: FENO(NIOX-MINO) = 10 + [1.5 FENO(N-6008)]. We did not observe statistically significant correlations between FENO measurements and age, sex, body mass index, or spirometry." ] "es" => array:1 [ "resumen" => "La determinación de óxido nítrico en aire espirado (FENO) es una técnica no invasiva que se utiliza en la evaluación clínica y el tratamiento del asma. El objetivo de este estudio ha sido determinar los valores de referencia de FENO en un grupo de voluntarios sanos mediante la utilización de un nuevo equipo portátil (NIOX-MINO® Aerocrine), así como determinar el grado de relación que presenta con el equipo de determinación habitual en nuestro laboratorio de función pulmonar (sensor de quimioluminiscencia N-6008® SIR). Según los resultados obtenidos, los valores de FENO que da el equipo portátil son siempre superiores a los que ofrece el sensor habitual, con un valor de corte de 34 ppb (media + 2 desviación estándar). Existe un relación directa y significativa de la determinación de FENO entre ambos equipos (r = 0,92; p = 0,001) con un factor de corrección de: FENO (NIOX-MINO®) = 10 + 1,5 FENO (N-6008®). 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methacholine responsiveness in patients with mild asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A Jatakanon" 1 => "L Sim" 2 => "S Kharitonov" 3 => "K Chung" 4 => "P Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1998" "volumen" => "53" "paginaInicial" => "91" "paginaFinal" => "95" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9624291" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "RC Strunk" 1 => "SJ Szefler" 2 => "B Phillips" 3 => "R Zeiger" 4 => "VM Chinchilli" 5 => "G Larsen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ann Allergy Asthma Inmunol" "fecha" => "2003" "volumen" => "112" "paginaInicial" => "883" "paginaFinal" => "892" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparisons between exhaled nitric oxide measurements and conventional tests" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "AD Smith" 1 => "JO Cowan" 2 => "S Filsell" 3 => "C MacLachlan" 4 => "G Monti-Sheedan" 5 => "P Jackson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200310-1376OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2004" "volumen" => "169" "paginaInicial" => "473" "paginaFinal" => "478" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14644933" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exhaled nitric oxide as a diagnosis test for asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A Deykin" 1 => "AF Massaro" 2 => "JM Drazen" 3 => "E Israel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.2201081" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2002" "volumen" => "165" "paginaInicial" => "1597" "paginaFinal" => "1601" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12070059" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "SA Kharitonov" 1 => "F Gonio" 2 => "C Kelly" 3 => "S Meah" 4 => "PJ Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Respir J" "fecha" => "2003" "volumen" => "21" "paginaInicial" => "443" "paginaFinal" => "448" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of exhaled nitric oxide measurements to guide treatment in chronic asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "AD Smith" 1 => "JO Cowan" 2 => "KP Brasset" 3 => "P Herbison" 4 => "DR Taylor" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa043596" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2005" "volumen" => "352" "paginaInicial" => "2163" "paginaFinal" => "2173" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15914548" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Yes to NO: the first studies on exhaled nitric oxidedriven asthma treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "JC de Jongste" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.05.00080705" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2005" "volumen" => "26" "paginaInicial" => "379" "paginaFinal" => "381" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16135716" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "American Thoracic Society" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200406-710ST" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2005" "volumen" => "171" "paginaInicial" => "912" "paginaFinal" => "930" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15817806" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Concentración de NO en el aire espirado: valores de referencia en población sana" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N Calaf" 1 => "JB de Lerma" 2 => "T Feixas" 3 => "M González" 4 => "E Codina" 5 => "P Casan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2004" "volumen" => "40" "numero" => "Supl 2" "paginaInicial" => "66" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aerocrine exhaled nitric oxide monitoring system NIOX is cleared by de US Food and Drug Administration for monitoring therapy is asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E Silkoff Philip" 1 => "M Carlson" 2 => "T Bourke" 3 => "R Katial" 4 => "E Ögren" 5 => "SJ Szefler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaci.2004.08.042" "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2004" "volumen" => "114" "paginaInicial" => "1241" "paginaFinal" => "1256" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15536442" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S Kharitonov" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "NIOX-MINO®: a new handheld exhaled NO device. Proceedings, European Respiratory Society 15th Annual Congress; 2005, September 17-21; Copenhagen" "fecha" => "2005" "editorial" => "European Respiratory Society" "editorialLocalizacion" => "Copenhagen" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Hemmingsson T, Linnarsson D, Gambert R. Novel hand-held device for exhaled nitric oxide analysis in research and clinical applications. Proceedings: Breath Gas Analysis for Medical Diagnosis; 2004, September 23-26; Dornbirn." ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004300000003/v1_201305150311/S1579212907600445/v1_201305150311/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004300000003/v1_201305150311/S1579212907600445/v1_201305150311/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600445?idApp=UINPBA00003Z"]

Archivos de Bronconeumología

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Vol. 43. Issue 3.

Pages 176-179 (January 2007)

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Pages 176-179 (January 2007)

Techniques And Procedures

DOI: 10.1016/S1579-2129(07)60044-5

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Measurement of Fraction of Exhaled Nitric Oxide With the Portable NIOX-MINO Monitor in Healthy Adult

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Ana María Fortuna, Teresa Feixas, Pere Casan

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pcasan@hsp.santpau.es

Correspondence: Dr. P. Casan. Unidad de Función Pulmonar. Hospital de la Santa Creu i Sant Pau. St. Antoni M. Claret, 167. 08025 Barcelona. España

Unidad de Función Pulmonar, Departamento de Neumología, Hospital de la Santa Creu i Sant Pau. Facultad de Medicina, Universidad Autónoma de Barcelona, Barcelona, Spain

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Measurement of the fraction of exhaled nitric oxide (FENO) provides a noninvasive way to monitor asthma treatment in clinical practice. The aim of this study was to determine FENO reference values for measurements recorded with the portable NIOX MINO monitor in a group of healthy volunteers. We also assessed the association between values recorded by the portable monitor and the N-6008 chemiluminescence analyzer used in our pulmonary function laboratory. The FENO values obtained with the portable monitor were consistently higher than those recorded by the N-6008 monitor; the cutoff value for the portable monitor was 34 ppb (mean + 2 SD). We detected a direct correlation (r=0.92) between the FENO measurements recorded by the 2 monitors (P=.001). The following equation expresses the relationship between measurements from the 2 devices: FENO(NIOX-MINO) = 10 + [1.5 FENO(N-6008)]. We did not observe statistically significant correlations between FENO measurements and age, sex, body mass index, or spirometry.

Key words:

Fraction of exhaled nitric oxide

Asthma

Inflammation

La determinación de óxido nítrico en aire espirado (FENO) es una técnica no invasiva que se utiliza en la evaluación clínica y el tratamiento del asma. El objetivo de este estudio ha sido determinar los valores de referencia de FENO en un grupo de voluntarios sanos mediante la utilización de un nuevo equipo portátil (NIOX-MINO® Aerocrine), así como determinar el grado de relación que presenta con el equipo de determinación habitual en nuestro laboratorio de función pulmonar (sensor de quimioluminiscencia N-6008® SIR). Según los resultados obtenidos, los valores de FENO que da el equipo portátil son siempre superiores a los que ofrece el sensor habitual, con un valor de corte de 34 ppb (media + 2 desviación estándar). Existe un relación directa y significativa de la determinación de FENO entre ambos equipos (r = 0,92; p = 0,001) con un factor de corrección de: FENO (NIOX-MINO®) = 10 + 1,5 FENO (N-6008®). La relación entre los valores de FENO y la edad, el sexo, el índice de masa corporal y los valores espirométricos no fue estadísticamente significativa.

Palabras clave:

Óxido nítrico en aire espirado

Asma

Inflamación

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REFERENCES

[1]

Global Initiative for Asthma.

Global Strategy for Asthma Management and Prevention NHLBI/WHO Workshop Report 2002.

Available from: http://www.ginasthma.com

[2]

A Jatakanon, L Sim, S Kharitonov, K Chung, P Barnes.

Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma.

Thorax, 53 (1998), pp. 91-95

Medline

[3]

RC Strunk, SJ Szefler, B Phillips, R Zeiger, VM Chinchilli, G Larsen, et al.

Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children.

Ann Allergy Asthma Inmunol, 112 (2003), pp. 883-892

[4]

AD Smith, JO Cowan, S Filsell, C MacLachlan, G Monti-Sheedan, P Jackson, et al.

Comparisons between exhaled nitric oxide measurements and conventional tests.

Am J Respir Crit Care Med, 169 (2004), pp. 473-478

http://dx.doi.org/10.1164/rccm.200310-1376OC | Medline

[5]

A Deykin, AF Massaro, JM Drazen, E Israel.

Exhaled nitric oxide as a diagnosis test for asthma.

Am J Respir Crit Care Med, 165 (2002), pp. 1597-1601

http://dx.doi.org/10.1164/rccm.2201081 | Medline

[6]

SA Kharitonov, F Gonio, C Kelly, S Meah, PJ Barnes.

Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children.

Eur Respir J, 21 (2003), pp. 443-448

[7]

AD Smith, JO Cowan, KP Brasset, P Herbison, DR Taylor.

Use of exhaled nitric oxide measurements to guide treatment in chronic asthma.

N Engl J Med, 352 (2005), pp. 2163-2173

http://dx.doi.org/10.1056/NEJMoa043596 | Medline

[8]

JC de Jongste.

Yes to NO: the first studies on exhaled nitric oxidedriven asthma treatment.

Eur Respir J, 26 (2005), pp. 379-381

http://dx.doi.org/10.1183/09031936.05.00080705 | Medline

[9]

American Thoracic Society.

Recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide.

Am J Respir Crit Care Med, 171 (2005), pp. 912-930

http://dx.doi.org/10.1164/rccm.200406-710ST | Medline

[10]

N Calaf, JB de Lerma, T Feixas, M González, E Codina, P Casan.

Concentración de NO en el aire espirado: valores de referencia en población sana.

Arch Bronconeumol, 40 (2004), pp. 66

[11]

E Silkoff Philip, M Carlson, T Bourke, R Katial, E Ögren, SJ Szefler.

Aerocrine exhaled nitric oxide monitoring system NIOX is cleared by de US Food and Drug Administration for monitoring therapy is asthma.

J Allergy Clin Immunol, 114 (2004), pp. 1241-1256

http://dx.doi.org/10.1016/j.jaci.2004.08.042 | Medline

[12]

S Kharitonov.

NIOX-MINO®: a new handheld exhaled NO device. Proceedings, European Respiratory Society 15th Annual Congress; 2005, September 17-21; Copenhagen, European Respiratory Society, (2005),

[13]

Hemmingsson T, Linnarsson D, Gambert R. Novel hand-held device for exhaled nitric oxide analysis in research and clinical applications. Proceedings: Breath Gas Analysis for Medical Diagnosis; 2004, September 23-26; Dornbirn.

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