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Vol. 26. Issue 7.
Pages 301-304 (October 1990)
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Vol. 26. Issue 7.
Pages 301-304 (October 1990)
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Efecto del bromuro de ipratropio sobre las caídas nocturnas de los flujos espiratorios en pacientes con asma crónico
Effect of ipratropium bromide on the nocturnal fall of expiratory flow in patients with chronic asthma
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M. Querol, B. Rodriguez Sanchón, P. Romero, F. Manresa
Servei de Pneumologia. Hospital de Bellvitge L’Hospitalet. Barcelona
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Al objeto de valorar la eficacia del bromuro de ipratropio (BI) para evitar la caída matinal de los picos de flujo (PEF) en asmáticos, se diseñó un estudio doble ciego cruzado entre bromuro de ipratropio y placebo. Se incluyeron 19 pacientes asmáticos con patrón de caídas matinales y en fase clínica estable, que en dos períodos de 15 días recibieron de forma aleatoria: BI 1 cápsula de 200mg o placebo cada 8 horas mediante aparato para inhalación. Antes, al finalizar la primera tanda de 15 días y al final de la segunda se determinó la espirometría simple con prueba broncodilatadora. Nuestros resultados muestran que el BI mejora significativamente los PEF medios a expensas de una mejoría de los PEF mínimos, por lo que concluimos que el BI mejora de forma significativa el grado de obstrucción.

To assess the efficacy of ipratropium bromide (IB) to prevent the nocturnal fall in peak flow in patients with asthma, a crossover, double blind study between ipratropium and placebo was undertaken. We included 19 asthmatic patients with an early morning fall in respiratory flow who were in a stable clinical condition. During two periods of 15 days they were randomized into IB 200mcg every 8 hours with an inhaler device or placebo. Simple spirometry with bronchodilatador test was performed before treatment and at the end of each period of treatment. Our results indicate that IB significantly improves the mean peak flow by ameliorating the minimun peak flow. We conclude that IB reduces significantly the degree of obstruction.

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Copyright © 1990. Sociedad Española de Neumología y Cirugía Torácica
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