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Vol. 39. Issue 2.
Pages 91-93 (February 2003)
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Vol. 39. Issue 2.
Pages 91-93 (February 2003)
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Edema agudo de pulmón no cardiogénico secundario a hidroclorotiazida
Acute non-cardiogenic pulmonary edema secondary to hydrochlorothiazide therapy
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B. Jara Chinarroa,
Corresponding author
beat1089@separ.es

Correspondencia: Servicio de Neumología. Hospital Universitario de Getafe.Ctra. de Toledo, Km 12,500. 28905 Getafe. Madrid. España
, J. De Miguel Díezb, J.L. García Satuea, M.A. Juretschke Moraguesa, J.A. Serrano Iglesiasa
a Servicio de Neumología. Hospital Universitario de Getafe. Getafe. Madrid
b Servicio de Neumología. Hospital Universitario Gregorio Marañón. Madrid. España
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Diversos fármacos utilizados con asiduidad pueden pro-ducir edema agudo de pulmón no cardiogénico. En la mayo-ría de los casos es difícil establecer la relación causal por la inespecificidad de los síntomas. Presentamos el caso clínico de un edema pulmonar inducido por un diurético de uso fre-cuente, la hidroclorotiazida. Esta complicación puede pre-sentarse tras la primera toma del fármaco, o aparecer en pacientes que lo habían tomado previamente sin problemas. Se debe a una reacción idiosincrásica, no inmunitaria. La evolución suele ser favorable en las primeras 14 h con trata-miento de soporte respiratorio y hemodinámico. En caso de recurrencia, aumenta la gravedad, por lo que señalamos la importancia del diagnóstico en el primer episodio

Palabras clave:
Edema de pulmón no cardiogénico
Hidroclorotiazida
Reacción a fármacos

Several commonly prescribed drugs can cause acute non-cardiogenic pulmonary edema. A cause-effect relationship is usually difficult to establish because symptoms are not specific. We report a case of pulmonary edema induced by a common diuretic, hydrochlorothiazide. This complication can occur after a first dose of the drug or in patients who have been taking it with no side effects. Edema is due to an idiosyncratic reaction rather than an immune response. The clinical course is usually favorable over the first 24 hours with treatment of blood pressure and respiratory support. Given that severity increases with recurrence, we underline the importance of diagnosis in the first episode

Keywords:
Non-cardiogenic pulmonary edema
Hydrochlorothiazide
Pharmacology
side effect
adverse reaction
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Copyright © 2003. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
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