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Vol. 25. Issue 2.
Pages 56-60 (March 1989)
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Vol. 25. Issue 2.
Pages 56-60 (March 1989)
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Curvas dosis-respuesta a la metacolina en asmaticos y sanos: utilidad de la determinacion del punto critico de separacion entre ambas
Dose-response curves to methacholine in asthmatic patients and in healthy individuals: usefulness of the determination of the critical separation point between both
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C. Pellicer Císcar, M. Perpiñá Tordera, V. Marco Martínez
Servicio de Neumología. Hospital la Fe. Valencia
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Hemos realizado un estudio comparativo de la curva dosis respuesta (CDR) a metacolina en 22 asmáticos y 15 sujetos normales, analizando cada punto de la curva y utilizando un análisis de la varianza, un test de la t y la determinación de la «least significant difference» (LSD). Nuestros resultados demuestran que el nivel crítico de separación de ambas curvas se sitúa a partir de la dosis 7,5 unidades inhalatorias de metacolina con un nivel de significación de p<0,01 para los distintos métodos de análisis empleados. En nuestra opinión, esta forma de analizar la. CDR permite la comparación de diferentes curvas a distintos niveles con la menor manipulación de los datos y abreviar, con la determinación de la LSD, el método de detección de hiperreactividad bronquial.

We have carried out a comparative study of the dose-res-ponse curve (DRC) to methacholine in 22 asthmatic patients and 15 healthy individuals, evaluating each point in the curve and using an analysis of variance, a t test and the measurement of the least significant difference (LSD). Our results show that the critical level of separation between both curves is located after the dose of 7,5 inhalatory units of methacholine, with a significant level of p<0,01 for the different analysis methods. In our Opinion, this type of evaluation of the DRC permits the comparison of different curves at different levels with the least data manipulation, and to shorten, by means of the LSD determination, the method of detection of bronchial hyperreactivity.

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Copyright © 1989. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
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