Curvas dosis-respuesta a la metacolina en asmaticos y sanos: utilidad de la determinacion del punto critico de separacion entre ambas
Dose-response curves to methacholine in asthmatic patients and in healthy individuals: usefulness of the determination of the critical separation point between both
C. Pellicer Císcar, M. Perpiñá Tordera, V. Marco Martínez
Servicio de Neumología. Hospital la Fe. Valencia
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Guijarro Jorge, A. Cueto Ladrón de Guevara, A. Sánchez-Palencia Ramos, F. Martí Huedo" "autores" => array:4 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Guijarro Jorge" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Cueto Ladrón de Guevara" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Sánchez-Palencia Ramos" ] 3 => array:2 [ "nombre" => "F." "apellidos" => "Martí Huedo" ] ] ] 1 => array:2 [ "autoresLista" => "S. Zilbermann Morales, F. París Romeu" "autores" => array:2 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Zilbermann Morales" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "París Romeu" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615317609?idApp=UINPBA00003Z" "url" => "/03002896/0000002500000002/v1_201509151020/S0300289615317609/v1_201509151020/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Curvas dosis-respuesta a la metacolina en asmaticos y sanos: utilidad de la determinacion del punto critico de separacion entre ambas" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "56" "paginaFinal" => "60" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "C. Pellicer Císcar, M. Perpiñá Tordera, V. Marco Martínez" "autores" => array:3 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Pellicer Císcar" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Perpiñá Tordera" ] 2 => array:2 [ "nombre" => "V." "apellidos" => "Marco Martínez" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Neumología. Hospital la Fe. Valencia" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Dose-response curves to methacholine in asthmatic patients and in healthy individuals: usefulness of the determination of the critical separation point between both" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1988-05-27" "fechaAceptado" => "1988-11-09" "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hemos realizado un estudio comparativo de la curva dosis respuesta (CDR) a metacolina en 22 asmáticos y 15 sujetos normales, analizando cada punto de la curva y utilizando un análisis de la varianza, un test de la t y la determinación de la «least significant difference» (LSD). Nuestros resultados demuestran que el nivel crítico de separación de ambas curvas se sitúa a partir de la dosis 7,5 unidades inhalatorias de metacolina con un nivel de significación de p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,01 para los distintos métodos de análisis empleados. En nuestra opinión, esta forma de analizar la. CDR permite la comparación de diferentes curvas a distintos niveles con la menor manipulación de los datos y abreviar, con la determinación de la LSD, el método de detección de hiperreactividad bronquial.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We have carried out a comparative study of the dose-res-ponse curve (DRC) to methacholine in 22 asthmatic patients and 15 healthy individuals, evaluating each point in the curve and using an analysis of variance, a t test and the measurement of the least significant difference (LSD). Our results show that the critical level of separation between both curves is located after the dose of 7,5 inhalatory units of methacholine, with a significant level of p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,01 for the different analysis methods. In our Opinion, this type of evaluation of the DRC permits the comparison of different curves at different levels with the least data manipulation, and to shorten, by means of the LSD determination, the method of detection of bronchial hyperreactivity.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Standardization of bronchial inhalation challenge procedures" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H. Chai" 1 => "R.S. Farr" 2 => "L.A. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 6 | 11 |
| 2024 October | 40 | 34 | 74 |
| 2024 September | 29 | 38 | 67 |
| 2024 August | 54 | 49 | 103 |
| 2024 July | 28 | 36 | 64 |
| 2024 June | 40 | 24 | 64 |
| 2024 May | 37 | 23 | 60 |
| 2024 April | 18 | 21 | 39 |
| 2024 March | 25 | 17 | 42 |
| 2024 February | 31 | 28 | 59 |
| 2024 January | 0 | 1 | 1 |
| 2023 December | 0 | 2 | 2 |
| 2023 November | 0 | 3 | 3 |
| 2023 October | 0 | 5 | 5 |
| 2023 July | 0 | 3 | 3 |
| 2023 June | 0 | 1 | 1 |
| 2023 May | 0 | 1 | 1 |
| 2023 April | 0 | 1 | 1 |
| 2023 March | 6 | 2 | 8 |
| 2023 February | 16 | 21 | 37 |
| 2023 January | 19 | 26 | 45 |
| 2022 December | 20 | 25 | 45 |
| 2022 November | 28 | 22 | 50 |
| 2022 October | 32 | 31 | 63 |
| 2022 September | 18 | 28 | 46 |
| 2022 August | 27 | 39 | 66 |
| 2022 July | 25 | 31 | 56 |
| 2022 June | 19 | 37 | 56 |
| 2022 May | 26 | 22 | 48 |
| 2022 April | 26 | 28 | 54 |
| 2022 March | 23 | 33 | 56 |
| 2022 February | 24 | 38 | 62 |
| 2022 January | 23 | 30 | 53 |
| 2021 December | 10 | 33 | 43 |
| 2021 November | 24 | 90 | 114 |
| 2021 October | 20 | 25 | 45 |
| 2021 September | 12 | 40 | 52 |
| 2021 August | 4 | 17 | 21 |
| 2021 July | 7 | 28 | 35 |
| 2021 June | 9 | 18 | 27 |
| 2021 May | 13 | 31 | 44 |
| 2021 April | 24 | 45 | 69 |
| 2021 March | 25 | 29 | 54 |
| 2021 February | 33 | 14 | 47 |
| 2021 January | 18 | 23 | 41 |
| 2020 December | 22 | 12 | 34 |
| 2020 November | 9 | 15 | 24 |
| 2020 October | 10 | 16 | 26 |
| 2020 September | 14 | 10 | 24 |
| 2020 August | 20 | 21 | 41 |
| 2020 July | 20 | 16 | 36 |
| 2020 June | 8 | 8 | 16 |
| 2020 May | 17 | 15 | 32 |
| 2020 April | 22 | 20 | 42 |
| 2020 March | 14 | 25 | 39 |
| 2020 February | 8 | 38 | 46 |
| 2020 January | 29 | 35 | 64 |
| 2019 December | 22 | 25 | 47 |
| 2019 November | 10 | 33 | 43 |
| 2019 October | 18 | 24 | 42 |
| 2019 September | 11 | 38 | 49 |
| 2019 August | 15 | 21 | 36 |
| 2019 July | 8 | 39 | 47 |
| 2019 June | 15 | 29 | 44 |
| 2019 May | 17 | 30 | 47 |
| 2019 April | 24 | 49 | 73 |
| 2019 March | 6 | 22 | 28 |
| 2019 February | 4 | 10 | 14 |
| 2019 January | 5 | 7 | 12 |
| 2018 December | 6 | 13 | 19 |
| 2018 November | 13 | 15 | 28 |
| 2018 October | 17 | 18 | 35 |
| 2018 September | 11 | 13 | 24 |
| 2018 May | 6 | 1 | 7 |
| 2018 April | 4 | 7 | 11 |
| 2018 March | 10 | 5 | 15 |
| 2018 February | 5 | 12 | 17 |
| 2018 January | 9 | 10 | 19 |
| 2017 December | 14 | 14 | 28 |
| 2017 November | 7 | 7 | 14 |
| 2017 October | 12 | 16 | 28 |
| 2017 September | 9 | 14 | 23 |
| 2017 August | 10 | 13 | 23 |
| 2017 July | 3 | 5 | 8 |
| 2017 June | 11 | 30 | 41 |
| 2017 May | 9 | 8 | 17 |
| 2017 April | 7 | 6 | 13 |
| 2017 March | 6 | 18 | 24 |
| 2017 February | 1 | 5 | 6 |
| 2017 January | 3 | 3 | 6 |
| 2016 December | 15 | 9 | 24 |
| 2016 November | 17 | 13 | 30 |
| 2016 October | 28 | 18 | 46 |
| 2016 September | 32 | 31 | 63 |
| 2016 August | 24 | 4 | 28 |
| 2016 July | 35 | 6 | 41 |
| 2016 June | 28 | 6 | 34 |
| 2016 May | 19 | 8 | 27 |
| 2016 April | 5 | 0 | 5 |
| 2016 March | 8 | 0 | 8 |
| 2016 February | 9 | 0 | 9 |
| 2016 January | 12 | 4 | 16 |
| 2015 December | 32 | 22 | 54 |
| 2015 November | 28 | 7 | 35 |
| 2015 October | 9 | 2 | 11 |
| 2015 September | 2 | 0 | 2 |
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