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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">TO ascertain whether climbing a mountain over 3000 meters high produces any alterations in ventilation&#44; whether such alterations are modified by acclimatization&#44; and whether they correlate with changes in arterial oxygen saturation &#40;SaO<span class="elsevierStyleInf">2</span>&#41; or the development of acute mountain sickness &#40;AMS&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Subjects and methods</span><p class="elsevierStyleSimplePara elsevierViewall">The following parameters were measured in 8 unacclimatized mountaineers who climbed Aneto &#40;3404 m&#41; and spent 3 days at the summit&#58; forced vital capacity &#40;FVC&#41;&#44; forced expiratory volume in 1 second &#40;FEV<span class="elsevierStyleInf">1</span>&#41;&#44; airway response to inhaled terbutaline&#44; SaO<span class="elsevierStyleInf">2</span>&#44; and the symptoms of AMS&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">At the summit&#44; mean &#40;SD&#41; FEV<span class="elsevierStyleInf">1</span> declined by 12&#46;3&#37; &#40;5&#46;7&#37;&#41; and mean FVC by 7&#46;6&#37; &#40;6&#46;7&#37;&#41; while the ratio of FEV<span class="elsevierStyleInf">1</span> to FVC remained normal&#46; The means for both parameters were higher on the following day&#46; No airway response to bronchodilator treatment was observed&#46; The restriction disappeared entirely on descent&#46; At the peak&#44; SaO<span class="elsevierStyleInf">2</span> increased progressively as the climbers became acclimatized&#46; During the ascent&#44; FEV<span class="elsevierStyleInf">1</span> correlated with SaO<span class="elsevierStyleInf">2</span> &#40;<span class="elsevierStyleItalic">r</span> &#61; 0&#46;79&#41;&#46; One participant who suffered from AMS had a ratio of FEV<span class="elsevierStyleInf">1</span> to FVC less than 70&#37; and the worst SaO<span class="elsevierStyleInf">2</span> during the 3 days on the summit&#46; Obstruction preceded the AMS symptoms&#44; did not respond to bronchodilator treatment&#44; and disappeared when the climber descended&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The mountaineers who climbed over 3000 meters presented restriction that correlated with hypoxemia&#46; This restriction did not respond to bronchodilator treatment&#44; improved with acclimatization&#44; and disappeared on descent&#46; One person with AMS presented obstruction that did not respond to terbutaline and disappeared on descent&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Averiguar si en la ascensi&#243;n a una monta&#241;a de m&#225;s de 3&#46;000 m se produce alguna alteraci&#243;n ventilatoria&#44; si &#233;sta se modifica por la aclimataci&#243;n y si se relaciona con los cambios en la saturaci&#243;n arterial de ox&#237;geno &#40;SaO<span class="elsevierStyleInf">2</span>&#41; o con la aparici&#243;n de s&#237;ntomas de mal de monta&#241;a agudo &#40;MAM&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Sujetos y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">En 8 monta&#241;eros no aclimatados que ascendieron a la cumbre del Aneto &#40;3&#46;404 m&#41; y permanecieron 3 d&#237;as en ella medimos&#58; la capacidad vital forzada &#40;FVC&#41;&#44; el volumen espiratorio forzado en el primer segundo &#40;FEV<span class="elsevierStyleInf">1</span>&#41;&#44; la respuesta a la inhalaci&#243;n de terbutalina&#44; la SaO<span class="elsevierStyleInf">2</span> y los s&#237;ntomas de MAM&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Al Ilegar a la cumbre disminuyeron el FEV<span class="elsevierStyleInf">1</span> &#40;12&#44;3 &#177; 5&#44;7&#37;&#41; y la FVC &#40;7&#44;6 &#177; 6&#44;7&#37;&#41; con la relaci&#243;n FEV<span class="elsevierStyleInf">1</span>&#47;FVC&#37; normal&#46; Al d&#237;a siguiente aumentaron ambos par&#225;metros&#46; No hubo respuesta al tratamiento broncodilatador&#46; La restricci&#243;n se corrigi&#243; totalmente al descender&#46; La SaO<span class="elsevierStyleInf">2</span> en la cumbre aument&#243; progresivamente con la aclimataci&#243;n&#46; Durante la ascensi&#243;n el FEV<span class="elsevierStyleInf">1</span> se correlacion&#243; con la SaO<span class="elsevierStyleInf">2</span> &#40;r &#61; 0&#44;79&#41;&#46; Un participante con MAM present&#243; FEV<span class="elsevierStyleInf">1</span>&#47;FVC menor del 70&#37; y la peor SaO<span class="elsevierStyleInf">2</span> durante la estancia en la cima&#46; Esta obstrucci&#243;n precedi&#243; a los s&#237;ntomas&#44; no cedi&#243; con tratamiento broncodilatador y se corrigi&#243; con el descenso&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los monta&#241;eros que ascienden a monta&#241;as de m&#225;s de 3&#46;000 m presentan una restricci&#243;n que se correlaciona con la hipoxemia&#44; no mejora con el tratamiento broncodilatador&#44; se alivia con la aclimataci&#243;n y desaparece con el descenso&#46; Un sujeto con MAM sufri&#243; una obstrucci&#243;n que no respondi&#243; a la terbutalina y desapareci&#243; con el descenso&#46;</p>"
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Vol. 41. Issue 10.
Pages 547-552 (October 2005)
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Vol. 41. Issue 10.
Pages 547-552 (October 2005)
Original Articles
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Changes in Spirometric Parameters and Arterial Oxygen Saturation During a Mountain Ascent to Over 3000 Meters
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L. Compte-Torreroa,
Corresponding author
compte_lui@gva.es

Correspondence: Dr. L. Compte-Torrero. Servicio de Neumología. Hospital Universitario La Fe. Avda. de Campanar, 21. 46009 Valencia. España
, J. Botella de Magliab, A. de Diego-Damiáa, L. Gómez-Pérezb, P. Ramírez-Galleymoreb, M. Perpiñá-Torderaa
a Servicio de Neumología, Hospital Universitario La Fe, Valencia, Spain
b Unidad de Medicina Intensiva, Hospital Universitario La Fe, Valencia, Spain
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Objective

TO ascertain whether climbing a mountain over 3000 meters high produces any alterations in ventilation, whether such alterations are modified by acclimatization, and whether they correlate with changes in arterial oxygen saturation (SaO2) or the development of acute mountain sickness (AMS).

Subjects and methods

The following parameters were measured in 8 unacclimatized mountaineers who climbed Aneto (3404 m) and spent 3 days at the summit: forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), airway response to inhaled terbutaline, SaO2, and the symptoms of AMS.

Results

At the summit, mean (SD) FEV1 declined by 12.3% (5.7%) and mean FVC by 7.6% (6.7%) while the ratio of FEV1 to FVC remained normal. The means for both parameters were higher on the following day. No airway response to bronchodilator treatment was observed. The restriction disappeared entirely on descent. At the peak, SaO2 increased progressively as the climbers became acclimatized. During the ascent, FEV1 correlated with SaO2 (r = 0.79). One participant who suffered from AMS had a ratio of FEV1 to FVC less than 70% and the worst SaO2 during the 3 days on the summit. Obstruction preceded the AMS symptoms, did not respond to bronchodilator treatment, and disappeared when the climber descended.

Conclusions

The mountaineers who climbed over 3000 meters presented restriction that correlated with hypoxemia. This restriction did not respond to bronchodilator treatment, improved with acclimatization, and disappeared on descent. One person with AMS presented obstruction that did not respond to terbutaline and disappeared on descent.

Key Words:
Spirometry
Arterial oxygen saturation
Acute mountain sickness
Acclimatization
Objetivo

Averiguar si en la ascensión a una montaña de más de 3.000 m se produce alguna alteración ventilatoria, si ésta se modifica por la aclimatación y si se relaciona con los cambios en la saturación arterial de oxígeno (SaO2) o con la aparición de síntomas de mal de montaña agudo (MAM).

Sujetos y métodos

En 8 montañeros no aclimatados que ascendieron a la cumbre del Aneto (3.404 m) y permanecieron 3 días en ella medimos: la capacidad vital forzada (FVC), el volumen espiratorio forzado en el primer segundo (FEV1), la respuesta a la inhalación de terbutalina, la SaO2 y los síntomas de MAM.

Resultados

Al Ilegar a la cumbre disminuyeron el FEV1 (12,3 ± 5,7%) y la FVC (7,6 ± 6,7%) con la relación FEV1/FVC% normal. Al día siguiente aumentaron ambos parámetros. No hubo respuesta al tratamiento broncodilatador. La restricción se corrigió totalmente al descender. La SaO2 en la cumbre aumentó progresivamente con la aclimatación. Durante la ascensión el FEV1 se correlacionó con la SaO2 (r = 0,79). Un participante con MAM presentó FEV1/FVC menor del 70% y la peor SaO2 durante la estancia en la cima. Esta obstrucción precedió a los síntomas, no cedió con tratamiento broncodilatador y se corrigió con el descenso.

Conclusiones

Los montañeros que ascienden a montañas de más de 3.000 m presentan una restricción que se correlaciona con la hipoxemia, no mejora con el tratamiento broncodilatador, se alivia con la aclimatación y desaparece con el descenso. Un sujeto con MAM sufrió una obstrucción que no respondió a la terbutalina y desapareció con el descenso.

Palabras clave:
Espirometría
Saturación arterial de oxígeno
Mal agudo de montaña
Aclimatación
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