Original Articles
Changes in Spirometric Parameters and Arterial Oxygen Saturation During a Mountain Ascent to Over 3000 Meters
L. Compte-Torreroa,
, J. Botella de Magliab, A. de Diego-Damiáa, L. Gómez-Pérezb, P. Ramírez-Galleymoreb, M. Perpiñá-Torderaa
Corresponding author
compte_lui@gva.es
Correspondence: Dr. L. Compte-Torrero. Servicio de Neumología. Hospital Universitario La Fe. Avda. de Campanar, 21. 46009 Valencia. España
Correspondence: Dr. L. Compte-Torrero. Servicio de Neumología. Hospital Universitario La Fe. Avda. de Campanar, 21. 46009 Valencia. España
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Compte-Torrero, J. Botella de Maglia, A. de Diego-Damiá, L. Gómez-Pérez, P. Ramírez-Galleymore, M. Perpiñá-Tordera" "autores" => array:6 [ 0 => array:5 [ "preGrado" => "Dr." "nombre" => "L." "apellidos" => "Compte-Torrero" "email" => array:1 [ 0 => "compte_lui@gva.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "J." "apellidos" => "Botella de Maglia" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "de Diego-Damiá" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "L." "apellidos" => "Gómez-Pérez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 4 => array:3 [ "nombre" => "P." "apellidos" => "Ramírez-Galleymore" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 5 => array:3 [ "nombre" => "M." "apellidos" => "Perpiñá-Tordera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario La Fe, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Unidad de Medicina Intensiva, Hospital Universitario La Fe, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. L. Compte-Torrero. Servicio de Neumología. Hospital Universitario La Fe. Avda. de Campanar, 21. 46009 Valencia. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-09-22" "fechaAceptado" => "2005-03-15" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key Words" "identificador" => "xpalclavsec153705" "palabras" => array:4 [ 0 => "Spirometry" 1 => "Arterial oxygen saturation" 2 => "Acute mountain sickness" 3 => "Acclimatization" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec153704" "palabras" => array:4 [ 0 => "Espirometría" 1 => "Saturación arterial de oxígeno" 2 => "Mal agudo de montaña" 3 => "Aclimatación" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">TO ascertain whether climbing a mountain over 3000 meters high produces any alterations in ventilation, whether such alterations are modified by acclimatization, and whether they correlate with changes in arterial oxygen saturation (SaO<span class="elsevierStyleInf">2</span>) or the development of acute mountain sickness (AMS).</p> <span class="elsevierStyleSectionTitle">Subjects and methods</span><p class="elsevierStyleSimplePara elsevierViewall">The following parameters were measured in 8 unacclimatized mountaineers who climbed Aneto (3404 m) and spent 3 days at the summit: forced vital capacity (FVC), forced expiratory volume in 1 second (FEV<span class="elsevierStyleInf">1</span>), airway response to inhaled terbutaline, SaO<span class="elsevierStyleInf">2</span>, and the symptoms of AMS.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">At the summit, mean (SD) FEV<span class="elsevierStyleInf">1</span> declined by 12.3% (5.7%) and mean FVC by 7.6% (6.7%) while the ratio of FEV<span class="elsevierStyleInf">1</span> to FVC remained normal. The means for both parameters were higher on the following day. No airway response to bronchodilator treatment was observed. The restriction disappeared entirely on descent. At the peak, SaO<span class="elsevierStyleInf">2</span> increased progressively as the climbers became acclimatized. During the ascent, FEV<span class="elsevierStyleInf">1</span> correlated with SaO<span class="elsevierStyleInf">2</span> (<span class="elsevierStyleItalic">r</span> = 0.79). One participant who suffered from AMS had a ratio of FEV<span class="elsevierStyleInf">1</span> to FVC less than 70% and the worst SaO<span class="elsevierStyleInf">2</span> during the 3 days on the summit. Obstruction preceded the AMS symptoms, did not respond to bronchodilator treatment, and disappeared when the climber descended.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The mountaineers who climbed over 3000 meters presented restriction that correlated with hypoxemia. This restriction did not respond to bronchodilator treatment, improved with acclimatization, and disappeared on descent. One person with AMS presented obstruction that did not respond to terbutaline and disappeared on descent.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Averiguar si en la ascensión a una montaña de más de 3.000 m se produce alguna alteración ventilatoria, si ésta se modifica por la aclimatación y si se relaciona con los cambios en la saturación arterial de oxígeno (SaO<span class="elsevierStyleInf">2</span>) o con la aparición de síntomas de mal de montaña agudo (MAM).</p> <span class="elsevierStyleSectionTitle">Sujetos y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">En 8 montañeros no aclimatados que ascendieron a la cumbre del Aneto (3.404 m) y permanecieron 3 días en ella medimos: la capacidad vital forzada (FVC), el volumen espiratorio forzado en el primer segundo (FEV<span class="elsevierStyleInf">1</span>), la respuesta a la inhalación de terbutalina, la SaO<span class="elsevierStyleInf">2</span> y los síntomas de MAM.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Al Ilegar a la cumbre disminuyeron el FEV<span class="elsevierStyleInf">1</span> (12,3 ± 5,7%) y la FVC (7,6 ± 6,7%) con la relación FEV<span class="elsevierStyleInf">1</span>/FVC% normal. Al día siguiente aumentaron ambos parámetros. No hubo respuesta al tratamiento broncodilatador. La restricción se corrigió totalmente al descender. La SaO<span class="elsevierStyleInf">2</span> en la cumbre aumentó progresivamente con la aclimatación. Durante la ascensión el FEV<span class="elsevierStyleInf">1</span> se correlacionó con la SaO<span class="elsevierStyleInf">2</span> (r = 0,79). Un participante con MAM presentó FEV<span class="elsevierStyleInf">1</span>/FVC menor del 70% y la peor SaO<span class="elsevierStyleInf">2</span> durante la estancia en la cima. Esta obstrucción precedió a los síntomas, no cedió con tratamiento broncodilatador y se corrigió con el descenso.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los montañeros que ascienden a montañas de más de 3.000 m presentan una restricción que se correlaciona con la hipoxemia, no mejora con el tratamiento broncodilatador, se alivia con la aclimatación y desaparece con el descenso. Un sujeto con MAM sufrió una obstrucción que no respondió a la terbutalina y desapareció con el descenso.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:43 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cambios respiratorios durante la ascensión a una montaña de más de 8.000 metros" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L Compte Torrero" 1 => "RM Real Soriano" 2 => "J Botella de Maglia" 3 => "A de Diego Damiá" 4 => "V Macián Gisbert" 5 => "M Perpiñá Tordera" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2002" "volumen" => "118" "paginaInicial" => "47" "paginaFinal" => "52" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 1 | 3 |
| 2024 October | 31 | 32 | 63 |
| 2024 September | 25 | 25 | 50 |
| 2024 August | 47 | 43 | 90 |
| 2024 July | 24 | 27 | 51 |
| 2024 June | 41 | 41 | 82 |
| 2024 May | 42 | 36 | 78 |
| 2024 April | 15 | 24 | 39 |
| 2024 March | 22 | 19 | 41 |
| 2024 February | 22 | 22 | 44 |
| 2023 June | 0 | 1 | 1 |
| 2023 March | 2 | 5 | 7 |
| 2023 February | 17 | 27 | 44 |
| 2023 January | 15 | 27 | 42 |
| 2022 December | 21 | 31 | 52 |
| 2022 November | 23 | 25 | 48 |
| 2022 October | 17 | 28 | 45 |
| 2022 September | 12 | 25 | 37 |
| 2022 August | 29 | 39 | 68 |
| 2022 July | 40 | 64 | 104 |
| 2022 June | 16 | 26 | 42 |
| 2022 May | 32 | 43 | 75 |
| 2022 April | 20 | 24 | 44 |
| 2022 March | 29 | 41 | 70 |
| 2022 February | 20 | 26 | 46 |
| 2022 January | 11 | 30 | 41 |
| 2021 December | 13 | 48 | 61 |
| 2021 November | 19 | 45 | 64 |
| 2021 October | 19 | 54 | 73 |
| 2021 September | 17 | 49 | 66 |
| 2021 August | 8 | 21 | 29 |
| 2021 July | 9 | 27 | 36 |
| 2021 June | 16 | 36 | 52 |
| 2021 May | 9 | 22 | 31 |
| 2021 April | 29 | 45 | 74 |
| 2021 March | 21 | 15 | 36 |
| 2021 February | 14 | 19 | 33 |
| 2021 January | 7 | 11 | 18 |
| 2020 December | 6 | 18 | 24 |
| 2020 November | 6 | 11 | 17 |
| 2020 October | 5 | 8 | 13 |
| 2020 September | 2 | 5 | 7 |
| 2020 August | 10 | 12 | 22 |
| 2020 July | 11 | 20 | 31 |
| 2020 June | 11 | 2 | 13 |
| 2020 May | 14 | 17 | 31 |
| 2020 April | 11 | 16 | 27 |
| 2020 March | 8 | 11 | 19 |
| 2020 February | 13 | 14 | 27 |
| 2020 January | 16 | 22 | 38 |
| 2019 December | 19 | 22 | 41 |
| 2019 November | 7 | 10 | 17 |
| 2019 October | 12 | 8 | 20 |
| 2019 September | 8 | 7 | 15 |
| 2019 August | 11 | 6 | 17 |
| 2019 July | 17 | 15 | 32 |
| 2019 June | 7 | 4 | 11 |
| 2019 May | 21 | 15 | 36 |
| 2019 April | 31 | 35 | 66 |
| 2019 March | 11 | 21 | 32 |
| 2019 February | 7 | 11 | 18 |
| 2019 January | 6 | 12 | 18 |
| 2018 December | 8 | 16 | 24 |
| 2018 November | 11 | 6 | 17 |
| 2018 October | 16 | 13 | 29 |
| 2018 September | 9 | 14 | 23 |
| 2018 May | 6 | 0 | 6 |
| 2018 April | 7 | 8 | 15 |
| 2018 March | 2 | 4 | 6 |
| 2018 February | 8 | 12 | 20 |
| 2018 January | 4 | 4 | 8 |
| 2017 December | 5 | 9 | 14 |
| 2017 November | 3 | 8 | 11 |
| 2017 October | 4 | 12 | 16 |
| 2017 September | 5 | 11 | 16 |
| 2017 August | 8 | 22 | 30 |
| 2017 July | 7 | 8 | 15 |
| 2017 June | 6 | 17 | 23 |
| 2017 May | 9 | 17 | 26 |
| 2017 April | 2 | 6 | 8 |
| 2017 March | 3 | 7 | 10 |
| 2017 February | 2 | 6 | 8 |
| 2017 January | 1 | 8 | 9 |
| 2016 December | 8 | 10 | 18 |
| 2016 November | 12 | 11 | 23 |
| 2016 October | 14 | 20 | 34 |
| 2016 September | 11 | 15 | 26 |
| 2016 August | 8 | 4 | 12 |
| 2016 July | 6 | 4 | 10 |
| 2016 March | 2 | 0 | 2 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 53 | 1 | 54 |
| 2015 September | 55 | 11 | 66 |
| 2015 August | 39 | 14 | 53 |
| 2015 July | 86 | 19 | 105 |
| 2015 June | 47 | 9 | 56 |
| 2015 May | 46 | 12 | 58 |
| 2015 April | 61 | 10 | 71 |
| 2015 March | 34 | 8 | 42 |
| 2015 February | 57 | 5 | 62 |
| 2015 January | 44 | 10 | 54 |
| 2014 December | 47 | 12 | 59 |
| 2014 November | 48 | 9 | 57 |
| 2014 October | 56 | 8 | 64 |
| 2014 September | 36 | 9 | 45 |
| 2014 August | 42 | 8 | 50 |
| 2014 July | 39 | 8 | 47 |
| 2014 June | 45 | 11 | 56 |
| 2014 May | 45 | 13 | 58 |
| 2014 April | 43 | 8 | 51 |
| 2014 March | 62 | 11 | 73 |
| 2014 February | 60 | 12 | 72 |
| 2014 January | 37 | 6 | 43 |
| 2013 December | 60 | 12 | 72 |
| 2013 November | 43 | 3 | 46 |
| 2013 October | 48 | 11 | 59 |
| 2013 September | 54 | 6 | 60 |
| 2013 August | 53 | 10 | 63 |
| 2013 July | 52 | 19 | 71 |
| 2013 June | 44 | 13 | 57 |
| 2013 May | 47 | 8 | 55 |
| 2013 April | 25 | 8 | 33 |
| 2013 March | 12 | 4 | 16 |
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