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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Analizar los resultados de la radioterapia en el carcinoma no microc&#237;tico de pulm&#243;n y las caracter&#237;sticas cl&#237;-nicas y terap&#233;uticas que pueden influir en ellos</p> <span class="elsevierStyleSectionTitle">Pacientes Y M&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Sobre una base poblacional de 109 pacientes&#44; 87 cumplieron los criterios de inclusi&#243;n para el es-tudio&#46; Recibieron radioterapia tor&#225;cica sobre el volumen tu-moral macrosc&#243;pico y &#225;reas de drenaje linf&#225;tico&#44; en fraccio-namiento convencional&#46; El 61&#37; recibi&#243;&#44; adem&#225;s&#44; tratamiento sist&#233;mico con citost&#225;ticos</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La distribuci&#243;n por estadios fue&#58; 33&#37; &#40;28&#47;87&#41; I &#43; II&#59; 20&#37; &#40;18&#47;87&#41; IIIA&#44; y 47&#37; &#40;41&#47;87&#41; IIIB&#46; La do-sis media de radioterapia fue de 66&#44;7 Gy &#40;intervalo de con-fianza &#91;IC&#93; del 95&#37;&#44; 65&#8211;67&#41;&#46; Consigui&#243; la remisi&#243;n cl&#237;nica completa el 22&#37; &#40;18&#47;87&#41;&#44; de los cuales la mitad recidiv&#243; pos-teriormente&#59; el 26&#37; &#40;21&#47;87&#41; obtuvo una remisi&#243;n parcial y el 52&#37; &#40;42&#47;87&#41; no respondi&#243;&#46; Se encontraron diferencias esta-d&#237;sticamente significativas en la supervivencia actuarial&#44; se-g&#250;n la estadificaci&#243;n y respuesta tumoral&#46; La mediana de supervivencia para estadios I &#43; II fue de 29 meses &#40;IC del 95&#37;&#44; 19&#8211;39&#41;&#59; para los IIIA&#44; de 22 meses &#40;IC del 95&#37;&#44; 16&#8211;28&#41;&#44; y para los IIIB&#44; de 16 meses &#40;IC del 95&#37;&#44; 12&#44;20&#41;&#46; Las com-plicaciones m&#225;s frecuentes fueron las cut&#225;neas&#44; esof&#225;gicas y pulmonares&#44; con una baja incidencia de toxicidad grado 3 &#40;inferior al 3&#37;&#41; y ausencia de grado</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">No se encontraron diferencias en la super-vivencia seg&#250;n la edad&#44; localizaci&#243;n tumoral y tipo histol&#243;gi-co&#46; El control local de la enfermedad influy&#243; decisivamente en la supervivencia de estos pacientes</p>"
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Vol. 39. Issue 2.
Pages 81-86 (February 2003)
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Vol. 39. Issue 2.
Pages 81-86 (February 2003)
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Carcinoma no microcítico de pulmón. Supervivencia y factores pronósticos del tratamiento radioterápico
Non-small cell lung cancer. Survival after radiotherapy and prognostic factors
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J. Jaén Olasoloa,
Corresponding author
jjaen@hpm.sas.junta-andalucia.es

Correspondencia: Servicio de Oncología Radioterápica. Hospital Universitario Puerta del Mar.Avda. Ana de Viya, 21. 11009 Cádiz. España
, E. Alonso Redondoa, A. León Jiménezb, A. Rueda Ramosc
a Servicio de Oncología Radioterápica. Hospital Universitario Puerta del Mar. Cádiz
b Sección de Neumología. Hospital Universitario Puerta del Mar. Cádiz
c Servicio de Oncología Médica. Hospital Universitario Puerta del Mar. Cádiz. España
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Objetivo

Analizar los resultados de la radioterapia en el carcinoma no microcítico de pulmón y las características clí-nicas y terapéuticas que pueden influir en ellos

Pacientes Y Método

Sobre una base poblacional de 109 pacientes, 87 cumplieron los criterios de inclusión para el es-tudio. Recibieron radioterapia torácica sobre el volumen tu-moral macroscópico y áreas de drenaje linfático, en fraccio-namiento convencional. El 61% recibió, además, tratamiento sistémico con citostáticos

Resultados

La distribución por estadios fue: 33% (28/87) I + II; 20% (18/87) IIIA, y 47% (41/87) IIIB. La do-sis media de radioterapia fue de 66,7 Gy (intervalo de con-fianza [IC] del 95%, 65–67). Consiguió la remisión clínica completa el 22% (18/87), de los cuales la mitad recidivó pos-teriormente; el 26% (21/87) obtuvo una remisión parcial y el 52% (42/87) no respondió. Se encontraron diferencias esta-dísticamente significativas en la supervivencia actuarial, se-gún la estadificación y respuesta tumoral. La mediana de supervivencia para estadios I + II fue de 29 meses (IC del 95%, 19–39); para los IIIA, de 22 meses (IC del 95%, 16–28), y para los IIIB, de 16 meses (IC del 95%, 12,20). Las com-plicaciones más frecuentes fueron las cutáneas, esofágicas y pulmonares, con una baja incidencia de toxicidad grado 3 (inferior al 3%) y ausencia de grado

Conclusiones

No se encontraron diferencias en la super-vivencia según la edad, localización tumoral y tipo histológi-co. El control local de la enfermedad influyó decisivamente en la supervivencia de estos pacientes

Palabras clave:
Cáncer de pulmón
Radioterapia
Quimioterapia
Objective

To analyze the results of radiotherapy for non-small cell lung cancer and identify the clinical and the-rapeutic variables that might influence prognosis

Patients And Methods

In a population base of 109 pa-tients, 87 met the enrollment criteria. The patients received thoracic radiotherapy over the macroscopic tumor volume and lymph drainage areas, using conventional fractions. Systemic cytostatic therapy was also given to 61% of the pa-tients

Results

Staging was as follows: 33% (28/87) I and II, 20% (18/87) IIIA and 47% (41/87) IIIB. The mean radiothe-rapy dose was 66.7 Gy (95% CI, 65–67). Full clinical remis-sion was achieved by 22% (18/87), half of whom later suffe-red recurrences. Partial remission was achieved by 26% (21/87). No response was observed in 52% (42/87). Statistically significant differences in actuarial survival ra-tes were found for staging and tumor response. Mean survi-val for stages I and II was 29 months (95% CI, 19–39), for IIIA it was 22 (95% CI, 16–28) months, and for IIIB 16 months (95% CI, 12–20). The most common complications were cutaneous, esophageal and pulmonary, with a low inci-dence of grade 3 toxicity (less than 3%) and absence of gra-de 4

Conclusions

No differences in survival were observed for age, tumor location or histological type. Local control of the disease decisively influenced patient survival

Keywords:
Lung cancer
Radiotherapy
Chemotherapy
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