Carcinoma no microcítico de pulmón. Supervivencia y factores pronósticos del tratamiento radioterápico
Non-small cell lung cancer. Survival after radiotherapy and prognostic factors
J. Jaén Olasoloa,
, E. Alonso Redondoa, A. León Jiménezb, A. Rueda Ramosc
Corresponding author
jjaen@hpm.sas.junta-andalucia.es
Correspondencia: Servicio de Oncología Radioterápica. Hospital Universitario Puerta del Mar.Avda. Ana de Viya, 21. 11009 Cádiz. España
Correspondencia: Servicio de Oncología Radioterápica. Hospital Universitario Puerta del Mar.Avda. Ana de Viya, 21. 11009 Cádiz. España
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"apellidos" => "Jaén Olasolo" "email" => array:1 [ 0 => "jjaen@hpm.sas.junta-andalucia.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "E." "apellidos" => "Alonso Redondo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "León Jiménez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "Rueda Ramos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Oncología Radioterápica. Hospital Universitario Puerta del Mar. Cádiz" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Sección de Neumología. Hospital Universitario Puerta del Mar. Cádiz" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Oncología Médica. Hospital Universitario Puerta del Mar. Cádiz. España" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Servicio de Oncología Radioterápica. Hospital Universitario Puerta del Mar.Avda. Ana de Viya, 21. 11009 Cádiz. España" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Non-small cell lung cancer. Survival after radiotherapy and prognostic factors" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2001-12-27" "fechaAceptado" => "2002-09-17" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec190516" "palabras" => array:3 [ 0 => "Cáncer de pulmón" 1 => "Radioterapia" 2 => "Quimioterapia" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec190515" "palabras" => array:3 [ 0 => "Lung cancer" 1 => "Radiotherapy" 2 => "Chemotherapy" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Analizar los resultados de la radioterapia en el carcinoma no microcítico de pulmón y las características clí-nicas y terapéuticas que pueden influir en ellos</p> <span class="elsevierStyleSectionTitle">Pacientes Y Método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Sobre una base poblacional de 109 pacientes, 87 cumplieron los criterios de inclusión para el es-tudio. Recibieron radioterapia torácica sobre el volumen tu-moral macroscópico y áreas de drenaje linfático, en fraccio-namiento convencional. El 61% recibió, además, tratamiento sistémico con citostáticos</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La distribución por estadios fue: 33% (28/87) I + II; 20% (18/87) IIIA, y 47% (41/87) IIIB. La do-sis media de radioterapia fue de 66,7 Gy (intervalo de con-fianza [IC] del 95%, 65–67). Consiguió la remisión clínica completa el 22% (18/87), de los cuales la mitad recidivó pos-teriormente; el 26% (21/87) obtuvo una remisión parcial y el 52% (42/87) no respondió. Se encontraron diferencias esta-dísticamente significativas en la supervivencia actuarial, se-gún la estadificación y respuesta tumoral. La mediana de supervivencia para estadios I + II fue de 29 meses (IC del 95%, 19–39); para los IIIA, de 22 meses (IC del 95%, 16–28), y para los IIIB, de 16 meses (IC del 95%, 12,20). Las com-plicaciones más frecuentes fueron las cutáneas, esofágicas y pulmonares, con una baja incidencia de toxicidad grado 3 (inferior al 3%) y ausencia de grado</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">No se encontraron diferencias en la super-vivencia según la edad, localización tumoral y tipo histológi-co. El control local de la enfermedad influyó decisivamente en la supervivencia de estos pacientes</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To analyze the results of radiotherapy for non-small cell lung cancer and identify the clinical and the-rapeutic variables that might influence prognosis</p> <span class="elsevierStyleSectionTitle">Patients And Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">In a population base of 109 pa-tients, 87 met the enrollment criteria. The patients received thoracic radiotherapy over the macroscopic tumor volume and lymph drainage areas, using conventional fractions. Systemic cytostatic therapy was also given to 61% of the pa-tients</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Staging was as follows: 33% (28/87) I and II, 20% (18/87) IIIA and 47% (41/87) IIIB. The mean radiothe-rapy dose was 66.7 Gy (95% CI, 65–67). Full clinical remis-sion was achieved by 22% (18/87), half of whom later suffe-red recurrences. Partial remission was achieved by 26% (21/87). No response was observed in 52% (42/87). Statistically significant differences in actuarial survival ra-tes were found for staging and tumor response. Mean survi-val for stages I and II was 29 months (95% CI, 19–39), for IIIA it was 22 (95% CI, 16–28) months, and for IIIB 16 months (95% CI, 12–20). The most common complications were cutaneous, esophageal and pulmonary, with a low inci-dence of grade 3 toxicity (less than 3%) and absence of gra-de 4</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">No differences in survival were observed for age, tumor location or histological type. Local control of the disease decisively influenced patient survival</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:42 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characterization of the lung cancer epidemic in the European Union (1970–1990)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. López-Albente" 1 => "M. Pollan" 2 => "P. De la Iglesia" 3 => "M. 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Hauck" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Radiat Oncol Biol Phys" "fecha" => "2001" "volumen" => "51" "paginaInicial" => "56" "paginaFinal" => "61" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11641016" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Ball DL, Smith J, Wirth A, Mac Manus MP. Failure of stage to predict survival in patients with non-small cell lung cancer treated by radiotherapy with or without concomitant chemotherapy. Actas de 43rd Annual Meeting of the American Society for Therapeutic" ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/03002896/0000003900000002/v1_201307081521/S0300289603753277/v1_201307081521/es/main.assets" "Apartado" => array:4 [ "identificador" => "9277" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000003900000002/v1_201307081521/S0300289603753277/v1_201307081521/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289603753277?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 2 | 7 |
| 2024 October | 40 | 27 | 67 |
| 2024 September | 39 | 38 | 77 |
| 2024 August | 68 | 30 | 98 |
| 2024 July | 47 | 18 | 65 |
| 2024 June | 62 | 29 | 91 |
| 2024 May | 85 | 54 | 139 |
| 2024 April | 49 | 42 | 91 |
| 2024 March | 60 | 34 | 94 |
| 2024 February | 59 | 46 | 105 |
| 2024 January | 0 | 7 | 7 |
| 2023 December | 0 | 3 | 3 |
| 2023 November | 0 | 7 | 7 |
| 2023 October | 0 | 13 | 13 |
| 2023 September | 0 | 5 | 5 |
| 2023 August | 0 | 2 | 2 |
| 2023 July | 0 | 6 | 6 |
| 2023 June | 0 | 11 | 11 |
| 2023 April | 0 | 1 | 1 |
| 2023 March | 8 | 2 | 10 |
| 2023 February | 24 | 23 | 47 |
| 2023 January | 32 | 32 | 64 |
| 2022 December | 40 | 48 | 88 |
| 2022 November | 37 | 16 | 53 |
| 2022 October | 37 | 30 | 67 |
| 2022 September | 27 | 32 | 59 |
| 2022 August | 32 | 43 | 75 |
| 2022 July | 29 | 42 | 71 |
| 2022 June | 25 | 34 | 59 |
| 2022 May | 29 | 33 | 62 |
| 2022 April | 27 | 23 | 50 |
| 2022 March | 33 | 40 | 73 |
| 2022 February | 30 | 25 | 55 |
| 2022 January | 28 | 32 | 60 |
| 2021 December | 26 | 49 | 75 |
| 2021 November | 23 | 43 | 66 |
| 2021 October | 21 | 45 | 66 |
| 2021 September | 27 | 56 | 83 |
| 2021 August | 16 | 41 | 57 |
| 2021 July | 17 | 32 | 49 |
| 2021 June | 27 | 38 | 65 |
| 2021 May | 31 | 29 | 60 |
| 2021 April | 62 | 61 | 123 |
| 2021 March | 47 | 17 | 64 |
| 2021 February | 39 | 19 | 58 |
| 2021 January | 25 | 18 | 43 |
| 2020 December | 23 | 17 | 40 |
| 2020 November | 17 | 17 | 34 |
| 2020 October | 35 | 12 | 47 |
| 2020 September | 18 | 7 | 25 |
| 2020 August | 30 | 6 | 36 |
| 2020 July | 33 | 28 | 61 |
| 2020 June | 27 | 12 | 39 |
| 2020 May | 39 | 19 | 58 |
| 2020 April | 36 | 13 | 49 |
| 2020 March | 35 | 20 | 55 |
| 2020 February | 39 | 18 | 57 |
| 2020 January | 40 | 16 | 56 |
| 2019 December | 37 | 20 | 57 |
| 2019 November | 32 | 12 | 44 |
| 2019 October | 31 | 14 | 45 |
| 2019 September | 74 | 19 | 93 |
| 2019 August | 21 | 6 | 27 |
| 2019 July | 32 | 18 | 50 |
| 2019 June | 87 | 14 | 101 |
| 2019 May | 73 | 22 | 95 |
| 2019 April | 77 | 21 | 98 |
| 2019 March | 57 | 12 | 69 |
| 2019 February | 42 | 11 | 53 |
| 2019 January | 33 | 12 | 45 |
| 2018 December | 39 | 26 | 65 |
| 2018 November | 73 | 23 | 96 |
| 2018 October | 73 | 23 | 96 |
| 2018 September | 25 | 14 | 39 |
| 2018 August | 2 | 0 | 2 |
| 2018 May | 8 | 1 | 9 |
| 2018 April | 4 | 4 | 8 |
| 2018 March | 10 | 9 | 19 |
| 2018 February | 8 | 9 | 17 |
| 2018 January | 6 | 9 | 15 |
| 2017 December | 6 | 14 | 20 |
| 2017 November | 9 | 7 | 16 |
| 2017 October | 7 | 6 | 13 |
| 2017 September | 10 | 9 | 19 |
| 2017 August | 9 | 7 | 16 |
| 2017 July | 19 | 16 | 35 |
| 2017 June | 12 | 18 | 30 |
| 2017 May | 17 | 11 | 28 |
| 2017 April | 7 | 8 | 15 |
| 2017 March | 4 | 4 | 8 |
| 2017 February | 7 | 10 | 17 |
| 2017 January | 9 | 14 | 23 |
| 2016 December | 7 | 12 | 19 |
| 2016 November | 11 | 18 | 29 |
| 2016 October | 22 | 21 | 43 |
| 2016 September | 18 | 15 | 33 |
| 2016 August | 19 | 8 | 27 |
| 2016 July | 30 | 9 | 39 |
| 2016 June | 22 | 10 | 32 |
| 2016 May | 20 | 10 | 30 |
| 2016 April | 6 | 2 | 8 |
| 2016 March | 7 | 4 | 11 |
| 2016 February | 10 | 3 | 13 |
| 2016 January | 19 | 9 | 28 |
| 2015 December | 23 | 9 | 32 |
| 2015 November | 29 | 8 | 37 |
| 2015 October | 452 | 1 | 453 |
| 2015 September | 415 | 0 | 415 |
| 2015 August | 395 | 0 | 395 |
| 2015 July | 561 | 0 | 561 |
| 2015 June | 400 | 0 | 400 |
| 2015 May | 556 | 0 | 556 |
| 2015 April | 422 | 0 | 422 |
| 2015 March | 349 | 0 | 349 |
| 2015 February | 327 | 0 | 327 |
| 2015 January | 294 | 0 | 294 |
| 2014 December | 305 | 0 | 305 |
| 2014 November | 321 | 0 | 321 |
| 2014 October | 308 | 0 | 308 |
| 2014 September | 319 | 0 | 319 |
| 2014 August | 227 | 0 | 227 |
| 2014 July | 246 | 0 | 246 |
| 2014 June | 232 | 0 | 232 |
| 2014 May | 241 | 0 | 241 |
| 2014 April | 205 | 0 | 205 |
| 2014 March | 218 | 0 | 218 |
| 2014 February | 182 | 0 | 182 |
| 2014 January | 197 | 0 | 197 |
| 2013 December | 117 | 0 | 117 |
| 2013 November | 136 | 0 | 136 |
| 2013 October | 167 | 0 | 167 |
| 2013 September | 149 | 0 | 149 |
| 2013 August | 145 | 0 | 145 |
| 2013 July | 96 | 0 | 96 |
| 2013 June | 93 | 0 | 93 |
| 2013 May | 66 | 0 | 66 |
| 2013 April | 58 | 0 | 58 |
| 2013 March | 11 | 0 | 11 |
| 2000 January | 4034 | 0 | 4034 |
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