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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Recurrent hypoxia associated with sleep apnea-hypopnea syndrome &#40;SAHS&#41; leads to an increase in the degradation of adenosine triphosphatase to xanthine and&#44; secondarily&#44; to an increase in uric acid concentrations&#46; The aim of the present study was to determine whether there is a correlation between uric acid levels in peripheral blood and sleep-disordered breathing&#44; independently of known confounding factors&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We carried out a retrospective cross-sectional study of 1135 patients evaluated for suspected SAHS&#46; For all patients&#44; a medical history was taken using a standardized protocol&#46; In addition&#44; biochemical analysis of venous blood and an overnight sleep study &#40;with either conventional polysomnography or home monitoring&#41; were carried out&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The mean &#40;SD&#41; concentration of uric acid was 631 &#40;1&#46;5&#41; mg&#47;dL&#44; and 36&#37; of patients had concentrations above established normal values for their sex&#46; We found a significant correlation between uric acid levels and some steep study parameters &#40;number of respiratory events&#44; number of desaturations&#44; or the percentage of time with oxygen saturation less than 90&#37;&#41;&#46; Those patients with more respiratory events &#40;apnea-bypopnea index or respiratory event index &#8805;30&#41; had higher uric acid levels than those with mild or no SAHS&#46; However&#44; this difference was not apparent in the univariate analysis of variance&#44; in which body mass index and cholesterol and triglyceride levels were considered confounding factors&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Uric acid levels are positively correlated with the number of obstructive respiratory episodes and oxygen desaturations during sleep&#44; but this correlation seems to be influenced bv other factors&#44; such as obesitv&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La hipoxia recurrente del si&#39;ndrome de apnea-hipopnea durante el sueno &#40;SAHS&#41; origina un aumento de la degradati&#243;n de adenosintrifosfato a xantina y&#44; secundariamente&#44; de las concentraciones de &#225;cido &#250;rico&#46; El prop&#243;sito del presente estudio ha sido analizar si existe relati&#243;n entre los valores de &#225;cido &#250;rico en sangre perif&#233;rica y los trastornos respiratorios durante el sue&#241;o&#44; independientemente de los factores de confusi&#243;n conocidos&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio transversal retrospectivo con 1&#46;135 pacientes evaluados por sospecha de SAHS&#46; A todos ellos se les realizaron una historia cl&#237;nica protocolizada&#44; un estudio bioqu&#237;mico de sangre venosa y un estudio de sue&#241;o nocturno &#40;polisomnograf&#237;a conventional o poligraf&#237;a domiciliaria&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El valor medio &#40;&#177; desviaci&#243;n est&#225;ndar&#41; del &#225;cido &#250;rico fue de 6&#44;31 &#177; 1&#44;5 mg&#47;dl&#44; y el 36&#37; de los pacientes presentaban unas concentraciones de uricemia superiores a les establecidas como normales seg&#250;n el sexo&#46; Encontramos una correlati&#243;n significativa entre los valores de &#225;cido &#250;rico y algunos par&#225;mctros de los estudios de sue&#241;o &#40;n&#250;mero de eventos respiratorios&#44; n&#250;mero de desaturaciones o el porcentaje de registro con saturati&#243;n &#60; 90&#37;&#41;&#46; Los pacientes con mayor n&#250;mero de eventos respiratorios &#40;&#237;ndice de apneas-hipopneas o &#237;ndice de eventos respiratorios &#8805; 30&#41; ten&#237;an un valor m&#225;s alto de &#225;cido &#250;rico que aqu&#233;llos sin SAHS o con SAHS leve&#44; aunque esta diferencia desapareci&#243; al realizar un an&#225;lisis de la variancia univariante en el que se consideraron factores de confusi&#243;n el &#237;ndice de masa corporal y los valores de colesterol y triglic&#233;ridos&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los valores de uricemia aumentan a medida que lo hacen los episodios respiratorios obstructives y las desaturaciones durante el sue&#241;o&#44; pero este aumento parece condicionado por varios factores&#44; como la obesidad&#46;</p>"
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Vol. 42. Issue 10.
Pages 492-500 (October 2006)
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Vol. 42. Issue 10.
Pages 492-500 (October 2006)
Original Articles
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Blood Uric Acid Levels in Patients With Sleep-Disordered Breathing
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Aránzazu Ruiz García
Corresponding author
arevello@telefonica.net

Correspondence: Dra. A. Ruiz García. Mairena, 46, bloque 2, bajo 7. 41500 Alcalá de Guadaira. Sevilla. España
, Ángeles Sánchez Armengol, Estefanía Luque Crespo, Domingo García Aguilar, Auxiliadora Romero Falcön, Carmen Carmona Bernal, Francisco Capote
Unidad de Trastornos Respiratorios del Sueño, Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospitales Universitarios Virgen del Rocío, Sevilla, España
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Objective

Recurrent hypoxia associated with sleep apnea-hypopnea syndrome (SAHS) leads to an increase in the degradation of adenosine triphosphatase to xanthine and, secondarily, to an increase in uric acid concentrations. The aim of the present study was to determine whether there is a correlation between uric acid levels in peripheral blood and sleep-disordered breathing, independently of known confounding factors.

Patients and methods

We carried out a retrospective cross-sectional study of 1135 patients evaluated for suspected SAHS. For all patients, a medical history was taken using a standardized protocol. In addition, biochemical analysis of venous blood and an overnight sleep study (with either conventional polysomnography or home monitoring) were carried out.

Results

The mean (SD) concentration of uric acid was 631 (1.5) mg/dL, and 36% of patients had concentrations above established normal values for their sex. We found a significant correlation between uric acid levels and some steep study parameters (number of respiratory events, number of desaturations, or the percentage of time with oxygen saturation less than 90%). Those patients with more respiratory events (apnea-bypopnea index or respiratory event index ≥30) had higher uric acid levels than those with mild or no SAHS. However, this difference was not apparent in the univariate analysis of variance, in which body mass index and cholesterol and triglyceride levels were considered confounding factors.

Conclusions

Uric acid levels are positively correlated with the number of obstructive respiratory episodes and oxygen desaturations during sleep, but this correlation seems to be influenced bv other factors, such as obesitv.

Key words:
Sleep apnea-hypopnea syndrome
Uric acid
Diagnosis
Objetivo

La hipoxia recurrente del si'ndrome de apnea-hipopnea durante el sueno (SAHS) origina un aumento de la degradatión de adenosintrifosfato a xantina y, secundariamente, de las concentraciones de ácido úrico. El propósito del presente estudio ha sido analizar si existe relatión entre los valores de ácido úrico en sangre periférica y los trastornos respiratorios durante el sueño, independientemente de los factores de confusión conocidos.

Pacientes y métodos

Se ha realizado un estudio transversal retrospectivo con 1.135 pacientes evaluados por sospecha de SAHS. A todos ellos se les realizaron una historia clínica protocolizada, un estudio bioquímico de sangre venosa y un estudio de sueño nocturno (polisomnografía conventional o poligrafía domiciliaria).

Resultados

El valor medio (± desviación estándar) del ácido úrico fue de 6,31 ± 1,5 mg/dl, y el 36% de los pacientes presentaban unas concentraciones de uricemia superiores a les establecidas como normales según el sexo. Encontramos una correlatión significativa entre los valores de ácido úrico y algunos parámctros de los estudios de sueño (número de eventos respiratorios, número de desaturaciones o el porcentaje de registro con saturatión < 90%). Los pacientes con mayor número de eventos respiratorios (índice de apneas-hipopneas o índice de eventos respiratorios ≥ 30) tenían un valor más alto de ácido úrico que aquéllos sin SAHS o con SAHS leve, aunque esta diferencia desapareció al realizar un análisis de la variancia univariante en el que se consideraron factores de confusión el índice de masa corporal y los valores de colesterol y triglicéridos.

Conclusiones

Los valores de uricemia aumentan a medida que lo hacen los episodios respiratorios obstructives y las desaturaciones durante el sueño, pero este aumento parece condicionado por varios factores, como la obesidad.

Palabras clave:
Síndrome de apnea-hipopnea durante el sueño (SAHS)
Ácido úrico
Diagnóstico
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Copyright © 2006. Sociedad Española de Neumología y Cirugía Torácica (SEPAR)
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