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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Recurrent hypoxia associated with sleep apnea-hypopnea syndrome &#40;SAHS&#41; leads to an increase in the degradation of adenosine triphosphatase to xanthine and&#44; secondarily&#44; to an increase in uric acid concentrations&#46; The aim of the present study was to determine whether there is a correlation between uric acid levels in peripheral blood and sleep-disordered breathing&#44; independently of known confounding factors&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We carried out a retrospective cross-sectional study of 1135 patients evaluated for suspected SAHS&#46; For all patients&#44; a medical history was taken using a standardized protocol&#46; In addition&#44; biochemical analysis of venous blood and an overnight sleep study &#40;with either conventional polysomnography or home monitoring&#41; were carried out&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The mean &#40;SD&#41; concentration of uric acid was 631 &#40;1&#46;5&#41; mg&#47;dL&#44; and 36&#37; of patients had concentrations above established normal values for their sex&#46; We found a significant correlation between uric acid levels and some steep study parameters &#40;number of respiratory events&#44; number of desaturations&#44; or the percentage of time with oxygen saturation less than 90&#37;&#41;&#46; Those patients with more respiratory events &#40;apnea-bypopnea index or respiratory event index &#8805;30&#41; had higher uric acid levels than those with mild or no SAHS&#46; However&#44; this difference was not apparent in the univariate analysis of variance&#44; in which body mass index and cholesterol and triglyceride levels were considered confounding factors&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Uric acid levels are positively correlated with the number of obstructive respiratory episodes and oxygen desaturations during sleep&#44; but this correlation seems to be influenced bv other factors&#44; such as obesitv&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La hipoxia recurrente del si&#39;ndrome de apnea-hipopnea durante el sueno &#40;SAHS&#41; origina un aumento de la degradati&#243;n de adenosintrifosfato a xantina y&#44; secundariamente&#44; de las concentraciones de &#225;cido &#250;rico&#46; El prop&#243;sito del presente estudio ha sido analizar si existe relati&#243;n entre los valores de &#225;cido &#250;rico en sangre perif&#233;rica y los trastornos respiratorios durante el sue&#241;o&#44; independientemente de los factores de confusi&#243;n conocidos&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio transversal retrospectivo con 1&#46;135 pacientes evaluados por sospecha de SAHS&#46; A todos ellos se les realizaron una historia cl&#237;nica protocolizada&#44; un estudio bioqu&#237;mico de sangre venosa y un estudio de sue&#241;o nocturno &#40;polisomnograf&#237;a conventional o poligraf&#237;a domiciliaria&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El valor medio &#40;&#177; desviaci&#243;n est&#225;ndar&#41; del &#225;cido &#250;rico fue de 6&#44;31 &#177; 1&#44;5 mg&#47;dl&#44; y el 36&#37; de los pacientes presentaban unas concentraciones de uricemia superiores a les establecidas como normales seg&#250;n el sexo&#46; Encontramos una correlati&#243;n significativa entre los valores de &#225;cido &#250;rico y algunos par&#225;mctros de los estudios de sue&#241;o &#40;n&#250;mero de eventos respiratorios&#44; n&#250;mero de desaturaciones o el porcentaje de registro con saturati&#243;n &#60; 90&#37;&#41;&#46; Los pacientes con mayor n&#250;mero de eventos respiratorios &#40;&#237;ndice de apneas-hipopneas o &#237;ndice de eventos respiratorios &#8805; 30&#41; ten&#237;an un valor m&#225;s alto de &#225;cido &#250;rico que aqu&#233;llos sin SAHS o con SAHS leve&#44; aunque esta diferencia desapareci&#243; al realizar un an&#225;lisis de la variancia univariante en el que se consideraron factores de confusi&#243;n el &#237;ndice de masa corporal y los valores de colesterol y triglic&#233;ridos&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los valores de uricemia aumentan a medida que lo hacen los episodios respiratorios obstructives y las desaturaciones durante el sue&#241;o&#44; pero este aumento parece condicionado por varios factores&#44; como la obesidad&#46;</p>"
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Original Articles
Blood Uric Acid Levels in Patients With Sleep-Disordered Breathing
Aránzazu Ruiz García
Corresponding author
arevello@telefonica.net

Correspondence: Dra. A. Ruiz García. Mairena, 46, bloque 2, bajo 7. 41500 Alcalá de Guadaira. Sevilla. España
, Ángeles Sánchez Armengol, Estefanía Luque Crespo, Domingo García Aguilar, Auxiliadora Romero Falcön, Carmen Carmona Bernal, Francisco Capote
Unidad de Trastornos Respiratorios del Sueño, Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospitales Universitarios Virgen del Rocío, Sevilla, España
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