Correspondence: Dra. A. Ruiz García. Mairena, 46, bloque 2, bajo 7. 41500 Alcalá de Guadaira. Sevilla. España
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"nombre" => "Aránzazu Ruiz" "apellidos" => "García" "email" => array:1 [ 0 => "arevello@telefonica.net" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "Ángeles Sánchez" "apellidos" => "Armengol" ] 2 => array:2 [ "nombre" => "Estefanía Luque" "apellidos" => "Crespo" ] 3 => array:2 [ "nombre" => "Domingo García" "apellidos" => "Aguilar" ] 4 => array:2 [ "nombre" => "Auxiliadora Romero" "apellidos" => "Falcön" ] 5 => array:2 [ "nombre" => "Carmen Carmona" "apellidos" => "Bernal" ] 6 => array:2 [ "nombre" => "Francisco" "apellidos" => "Capote" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad de Trastornos Respiratorios del Sueño, Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospitales Universitarios Virgen del Rocío, Sevilla, España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dra. A. Ruiz García. Mairena, 46, bloque 2, bajo 7. 41500 Alcalá de Guadaira. Sevilla. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154186" "palabras" => array:3 [ 0 => "Sleep apnea-hypopnea syndrome" 1 => "Uric acid" 2 => "Diagnosis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154185" "palabras" => array:3 [ 0 => "Síndrome de apnea-hipopnea durante el sueño (SAHS)" 1 => "Ácido úrico" 2 => "Diagnóstico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Recurrent hypoxia associated with sleep apnea-hypopnea syndrome (SAHS) leads to an increase in the degradation of adenosine triphosphatase to xanthine and, secondarily, to an increase in uric acid concentrations. The aim of the present study was to determine whether there is a correlation between uric acid levels in peripheral blood and sleep-disordered breathing, independently of known confounding factors.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We carried out a retrospective cross-sectional study of 1135 patients evaluated for suspected SAHS. For all patients, a medical history was taken using a standardized protocol. In addition, biochemical analysis of venous blood and an overnight sleep study (with either conventional polysomnography or home monitoring) were carried out.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The mean (SD) concentration of uric acid was 631 (1.5) mg/dL, and 36% of patients had concentrations above established normal values for their sex. We found a significant correlation between uric acid levels and some steep study parameters (number of respiratory events, number of desaturations, or the percentage of time with oxygen saturation less than 90%). Those patients with more respiratory events (apnea-bypopnea index or respiratory event index ≥30) had higher uric acid levels than those with mild or no SAHS. However, this difference was not apparent in the univariate analysis of variance, in which body mass index and cholesterol and triglyceride levels were considered confounding factors.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Uric acid levels are positively correlated with the number of obstructive respiratory episodes and oxygen desaturations during sleep, but this correlation seems to be influenced bv other factors, such as obesitv.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La hipoxia recurrente del si'ndrome de apnea-hipopnea durante el sueno (SAHS) origina un aumento de la degradatión de adenosintrifosfato a xantina y, secundariamente, de las concentraciones de ácido úrico. El propósito del presente estudio ha sido analizar si existe relatión entre los valores de ácido úrico en sangre periférica y los trastornos respiratorios durante el sueño, independientemente de los factores de confusión conocidos.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio transversal retrospectivo con 1.135 pacientes evaluados por sospecha de SAHS. A todos ellos se les realizaron una historia clínica protocolizada, un estudio bioquímico de sangre venosa y un estudio de sueño nocturno (polisomnografía conventional o poligrafía domiciliaria).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El valor medio (± desviación estándar) del ácido úrico fue de 6,31 ± 1,5 mg/dl, y el 36% de los pacientes presentaban unas concentraciones de uricemia superiores a les establecidas como normales según el sexo. Encontramos una correlatión significativa entre los valores de ácido úrico y algunos parámctros de los estudios de sueño (número de eventos respiratorios, número de desaturaciones o el porcentaje de registro con saturatión < 90%). Los pacientes con mayor número de eventos respiratorios (índice de apneas-hipopneas o índice de eventos respiratorios ≥ 30) tenían un valor más alto de ácido úrico que aquéllos sin SAHS o con SAHS leve, aunque esta diferencia desapareció al realizar un análisis de la variancia univariante en el que se consideraron factores de confusión el índice de masa corporal y los valores de colesterol y triglicéridos.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los valores de uricemia aumentan a medida que lo hacen los episodios respiratorios obstructives y las desaturaciones durante el sueño, pero este aumento parece condicionado por varios factores, como la obesidad.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:31 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Application of three-dimensional body scanner: observation of prevalence of metabolic syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "JD Lin" 1 => "WK Chiou" 2 => "HF Weng" 3 => "JT Fang" 4 => "TH Liu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clnu.2004.04.005" "Revista" => array:6 [ "tituloSerie" => "Clin Nutr" "fecha" => "2004" "volumen" => "23" "paginaInicial" => "1313" "paginaFinal" => "1323" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15556253" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Respiratory complications of obesity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "AS Jubber" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Clin Pract" "fecha" => "2004" "volumen" => "58" "paginaInicial" => "573" "paginaFinal" => "580" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15311557" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of sleep-disordered breathing, sleep apnea and hypertension in a large community-based study: Sleep Heart Health Study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F Nieto" 1 => "T Young" 2 => "B Lind" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "2000" "volumen" => "283" "paginaInicial" => "1829" "paginaFinal" => "1836" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10770144" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prospective study of the association between sleep-disordered breathing and hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P Peppard" 1 => "T Young" 2 => "M Palta" 3 => "J Skatrud" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM200005113421901" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2000" "volumen" => "342" "paginaInicial" => "1378" "paginaFinal" => "1384" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10805822" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Overnight urinary acid: creatinine ratio for detection of sleep hypoxemia. 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Year/Month | Html | Total | |
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2024 November | 6 | 3 | 9 |
2024 October | 32 | 14 | 46 |
2024 September | 29 | 28 | 57 |
2024 August | 45 | 40 | 85 |
2024 July | 26 | 25 | 51 |
2024 June | 26 | 27 | 53 |
2024 May | 38 | 36 | 74 |
2024 April | 22 | 25 | 47 |
2024 March | 25 | 14 | 39 |
2024 February | 25 | 24 | 49 |
2023 March | 3 | 4 | 7 |
2023 February | 11 | 18 | 29 |
2023 January | 20 | 39 | 59 |
2022 December | 23 | 30 | 53 |
2022 November | 12 | 23 | 35 |
2022 October | 30 | 37 | 67 |
2022 September | 16 | 22 | 38 |
2022 August | 26 | 33 | 59 |
2022 July | 21 | 45 | 66 |
2022 June | 12 | 43 | 55 |
2022 May | 27 | 26 | 53 |
2022 April | 15 | 30 | 45 |
2022 March | 19 | 38 | 57 |
2022 February | 25 | 30 | 55 |
2022 January | 24 | 29 | 53 |
2021 December | 20 | 40 | 60 |
2021 November | 38 | 63 | 101 |
2021 October | 25 | 42 | 67 |
2021 September | 35 | 61 | 96 |
2021 August | 19 | 20 | 39 |
2021 July | 17 | 29 | 46 |
2021 June | 20 | 42 | 62 |
2021 May | 12 | 30 | 42 |
2021 April | 30 | 40 | 70 |
2021 March | 28 | 27 | 55 |
2021 February | 19 | 19 | 38 |
2021 January | 14 | 12 | 26 |
2020 December | 13 | 12 | 25 |
2020 November | 23 | 16 | 39 |
2020 October | 14 | 13 | 27 |
2020 September | 4 | 6 | 10 |
2020 August | 15 | 13 | 28 |
2020 July | 19 | 18 | 37 |
2020 June | 14 | 3 | 17 |
2020 May | 22 | 16 | 38 |
2020 April | 14 | 19 | 33 |
2020 March | 17 | 13 | 30 |
2020 February | 19 | 19 | 38 |
2020 January | 15 | 18 | 33 |
2019 December | 16 | 14 | 30 |
2019 November | 9 | 16 | 25 |
2019 October | 2 | 6 | 8 |
2019 September | 12 | 16 | 28 |
2019 August | 17 | 11 | 28 |
2019 July | 11 | 13 | 24 |
2019 June | 13 | 8 | 21 |
2019 May | 16 | 11 | 27 |
2019 April | 20 | 8 | 28 |
2019 March | 11 | 10 | 21 |
2019 February | 9 | 11 | 20 |
2019 January | 4 | 8 | 12 |
2018 December | 10 | 13 | 23 |
2018 November | 21 | 5 | 26 |
2018 October | 17 | 11 | 28 |
2018 September | 15 | 6 | 21 |
2018 May | 5 | 0 | 5 |
2018 April | 9 | 8 | 17 |
2018 March | 6 | 4 | 10 |
2018 February | 8 | 10 | 18 |
2018 January | 4 | 3 | 7 |
2017 December | 5 | 7 | 12 |
2017 November | 3 | 7 | 10 |
2017 October | 2 | 8 | 10 |
2017 September | 4 | 4 | 8 |
2017 August | 6 | 12 | 18 |
2017 July | 4 | 0 | 4 |
2017 June | 7 | 12 | 19 |
2017 May | 2 | 7 | 9 |
2017 April | 3 | 0 | 3 |
2017 March | 3 | 4 | 7 |
2017 February | 1 | 0 | 1 |
2017 January | 1 | 2 | 3 |
2016 December | 14 | 6 | 20 |
2016 November | 17 | 7 | 24 |
2016 October | 17 | 7 | 24 |
2016 September | 10 | 8 | 18 |
2016 August | 6 | 6 | 12 |
2016 July | 5 | 0 | 5 |
2016 March | 2 | 0 | 2 |
2016 January | 1 | 0 | 1 |
2015 December | 2 | 0 | 2 |
2015 October | 97 | 12 | 109 |
2015 September | 89 | 8 | 97 |
2015 August | 183 | 7 | 190 |
2015 July | 103 | 6 | 109 |
2015 June | 69 | 3 | 72 |
2015 May | 93 | 10 | 103 |
2015 April | 79 | 10 | 89 |
2015 March | 74 | 9 | 83 |
2015 February | 69 | 3 | 72 |
2015 January | 69 | 10 | 79 |
2014 December | 70 | 9 | 79 |
2014 November | 108 | 4 | 112 |
2014 October | 111 | 11 | 122 |
2014 September | 113 | 8 | 121 |
2014 August | 94 | 7 | 101 |
2014 July | 101 | 6 | 107 |
2014 June | 109 | 6 | 115 |
2014 May | 98 | 9 | 107 |
2014 April | 103 | 8 | 111 |
2014 March | 85 | 8 | 93 |
2014 February | 87 | 10 | 97 |
2014 January | 86 | 4 | 90 |
2013 December | 57 | 5 | 62 |
2013 November | 47 | 7 | 54 |
2013 October | 42 | 8 | 50 |
2013 September | 48 | 7 | 55 |
2013 August | 72 | 17 | 89 |
2013 July | 45 | 9 | 54 |
2013 June | 40 | 5 | 45 |
2013 May | 39 | 3 | 42 |
2013 April | 18 | 6 | 24 |
2013 March | 7 | 2 | 9 |