Aspectos inmunologicos de los carcinomas broncopulmonares: Correlacion con el estadio tumoral, respuesta a la terapeutica y supervivencia

Simó-Camps, E.; Manresa, F.; Anguera, A.; Vich, J.M.a; Batlló, E.; Vidal, G.; Puigdollers, J.M.a; Manresa-Formosa, G.

doi:10.1016/S0300-2896(15)32736-8

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"apellidos" => "Manresa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "**" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Anguera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "J.M.a" "apellidos" => "Vich" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "E." "apellidos" => "Batlló" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "***" "identificador" => "aff0015" ] ] ] 5 => array:3 [ "nombre" => "G." "apellidos" => "Vidal" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "**" "identificador" => "aff0010" ] ] ] 6 => array:3 [ "nombre" => "J.M.a" "apellidos" => "Puigdollers" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "***" "identificador" => "aff0015" ] ] ] 7 => array:3 [ "nombre" => "G." "apellidos" => "Manresa-Formosa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "**" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Departamento de Inmunología y Quimioterapia Antitumoral. Universidad Autónoma de Barcelona. Hospital Sagrado Corazón" "etiqueta" => "*" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Instituto de Neumología Clínica Ntra. Sra. de la Merced. Barcelona" "etiqueta" => "**" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Hospital del Sagrado Corazón. Barcelona" "etiqueta" => "***" "identificador" => "aff0015" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Inmunological aspects of bronchopulmonary carcinomas. Correlation with the tumor stage, response to therapy and survival rate" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "La inmunidad celular fue estudiada en 79 pacientes afectos de carcinoma de pulmón, 50 testigos sanos y 14 tumoraciones benignas, observando si existía relación entre el estudio inmunológico de los pacientes y el estadio clínico de la enfermedad. La hipersensibilidad retardada fue correlacionada con el tipo histológico tumoral, el estadio de la enfermedad, la respuesta a la quimioterapia, el pronóstico y la supervivencia. Pacientes con anergia presentaban tumores muy diferenciados, falta de respuesta a la terapéutica, avanzada enfermedad y escasa supervivencia. En los pacientes con buena respuesta inmune, la enfermedad se hallaba limitada, respondían más frecuentemente a la terapéutica y presentaban una mayor supervivencia" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "Cellular immunity was studied in 79 patients with carcinoma of the lung, 50 healthy individuals, and 14 cases with bening tumors, to see if there was any relationship between the immunological study of the patients and the clinical stage of the disease. The delayed hypersensitivity was related to the histological tumor type, the stage of the disease, response to chemotherapy, prognosis and survival rate. Anergic patients showed well differentiated tumors, lack of response to therapy, advanced disease, and low survival rate. In patients with good immune response the disease was limited, there was more frequent response to therapy and they displayed a higher survival rate." ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Manifestations of immunologic unresponsivenes in Hodhkin's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.C. Aisenberg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cancer Res." "fecha" => "1966" "volumen" => "26" "paginaInicial" => "1.152" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5955599" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cellular immunty in cured cáncer patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.L. Twomey" 1 => "W.J. Catalona" 2 => "P.B. 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Archivos de Bronconeumología

ISSN: 0300-2896

Archivos de Bronconeumologia is an international journal that publishes original studies whose content is based upon results of research initiatives dealing with several aspects of respiratory medicine including epidemiology, respiratory physiology, pathophysiology of respiratory diseases, clinical management, thoracic surgery, pediatric lung diseases, respiratory critical care, respiratory allergy and basic research. Other types of articles such as editorials, reviews, and different types of letters are also published in the journal. Additionally, the journal expresses the voice of the following scientific societies: the Spanish Respiratory Society of Pneumology and Thoracic Surgery (SEPAR; https://www.separ.es/), the Latin American Thoracic Society (ALAT; https://alatorax.org/), and the Iberian American Association of Thoracic Surgery (AIACT; http://www.aiatorax.com/).

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Vol. 12. Issue 2.

Pages 53-57 (April - June 1976)

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Pages 53-57 (April - June 1976)

DOI: 10.1016/S0300-2896(15)32736-8

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Aspectos inmunologicos de los carcinomas broncopulmonares: Correlacion con el estadio tumoral, respuesta a la terapeutica y supervivencia

Inmunological aspects of bronchopulmonary carcinomas. Correlation with the tumor stage, response to therapy and survival rate

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E. Simó-Camps*, F. Manresa**, A. Anguera*, J.M.a Vich*, E. Batlló***, G. Vidal**, J.M.a Puigdollers***, G. Manresa-Formosa**

* Departamento de Inmunología y Quimioterapia Antitumoral. Universidad Autónoma de Barcelona. Hospital Sagrado Corazón

** Instituto de Neumología Clínica Ntra. Sra. de la Merced. Barcelona

*** Hospital del Sagrado Corazón. Barcelona

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Resumen

La inmunidad celular fue estudiada en 79 pacientes afectos de carcinoma de pulmón, 50 testigos sanos y 14 tumoraciones benignas, observando si existía relación entre el estudio inmunológico de los pacientes y el estadio clínico de la enfermedad. La hipersensibilidad retardada fue correlacionada con el tipo histológico tumoral, el estadio de la enfermedad, la respuesta a la quimioterapia, el pronóstico y la supervivencia. Pacientes con anergia presentaban tumores muy diferenciados, falta de respuesta a la terapéutica, avanzada enfermedad y escasa supervivencia. En los pacientes con buena respuesta inmune, la enfermedad se hallaba limitada, respondían más frecuentemente a la terapéutica y presentaban una mayor supervivencia

Summary

Cellular immunity was studied in 79 patients with carcinoma of the lung, 50 healthy individuals, and 14 cases with bening tumors, to see if there was any relationship between the immunological study of the patients and the clinical stage of the disease. The delayed hypersensitivity was related to the histological tumor type, the stage of the disease, response to chemotherapy, prognosis and survival rate. Anergic patients showed well differentiated tumors, lack of response to therapy, advanced disease, and low survival rate. In patients with good immune response the disease was limited, there was more frequent response to therapy and they displayed a higher survival rate.

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