array:23 [
  "pii" => "S0300289615325072"
  "issn" => "03002896"
  "doi" => "10.1016/S0300-2896(15)32507-2"
  "estado" => "S300"
  "fechaPublicacion" => "1980-01-01"
  "aid" => "72576"
  "copyright" => "Sociedad Española de Neumología y Cirugía Torácica"
  "copyrightAnyo" => "1980"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 1980;16:7-11"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1112
    "formatos" => array:3 [
      "EPUB" => 59
      "HTML" => 574
      "PDF" => 479
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0300289615325084"
    "issn" => "03002896"
    "doi" => "10.1016/S0300-2896(15)32508-4"
    "estado" => "S300"
    "fechaPublicacion" => "1980-01-01"
    "aid" => "72577"
    "copyright" => "Sociedad Española de Neumología y Cirugía Torácica"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 1980;16:12-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1397
      "formatos" => array:3 [
        "EPUB" => 58
        "HTML" => 806
        "PDF" => 533
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Elasticidad pulmonar y diabetes mellitus juvenil"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "12"
          "paginaFinal" => "14"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Pulmonary elasticity and juvenile diabetes mellitus"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "F. Manresa Presas, P. Romero Colomer, B. Rodríguez Sanchón"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "F."
              "apellidos" => "Manresa Presas"
            ]
            1 => array:2 [
              "nombre" => "P."
              "apellidos" => "Romero Colomer"
            ]
            2 => array:2 [
              "nombre" => "B."
              "apellidos" => "Rodríguez Sanchón"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615325084?idApp=UINPBA00003Z"
    "url" => "/03002896/0000001600000001/v1_201509151242/S0300289615325084/v1_201509151242/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0300289615325060"
    "issn" => "03002896"
    "doi" => "10.1016/S0300-2896(15)32506-0"
    "estado" => "S300"
    "fechaPublicacion" => "1980-01-01"
    "aid" => "72575"
    "copyright" => "Sociedad Española de Neumología y Cirugía Torácica"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 1980;16:4-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1132
      "formatos" => array:3 [
        "EPUB" => 53
        "HTML" => 600
        "PDF" => 479
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Estenosis traqueales yatrogenicas"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "4"
          "paginaFinal" => "6"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Iatrogenic tracheal stenosis"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A. Clariana Pal, J.P. Díaz Jiménez, R. Coll Artés, L. Muñoz Díaz"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "A."
              "apellidos" => "Clariana Pal"
            ]
            1 => array:2 [
              "nombre" => "J.P."
              "apellidos" => "Díaz Jiménez"
            ]
            2 => array:2 [
              "nombre" => "R."
              "apellidos" => "Coll Artés"
            ]
            3 => array:2 [
              "nombre" => "L."
              "apellidos" => "Muñoz Díaz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615325060?idApp=UINPBA00003Z"
    "url" => "/03002896/0000001600000001/v1_201509151242/S0300289615325060/v1_201509151242/es/main.assets"
  ]
  "es" => array:12 [
    "idiomaDefecto" => true
    "titulo" => "Analisis citogenetico de exudados pleurales sospechosos de malignidad"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "7"
        "paginaFinal" => "11"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "L. García Quesada, J.A. Portero Sánchez, J.A. Cambronero Galache"
        "autores" => array:3 [
          0 => array:3 [
            "nombre" => "L."
            "apellidos" => "García Quesada"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "J&#46;A&#46;"
            "apellidos" => "Portero S&#225;nchez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;&#42;</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;A&#46;"
            "apellidos" => "Cambronero Galache"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;&#42;&#42;</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Departamento de Gen&#233;tica&#46; Fundaci&#243;n Jim&#233;nez&#46; D&#237;az&#44; Madrid"
            "etiqueta" => "&#42;"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Gen&#233;tica&#46; Fundaci&#243;n Jim&#233;nez&#46; D&#237;az&#44; Madrid"
            "etiqueta" => "&#42;&#42;"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Departamento de Medicina Interna&#46; Fundaci&#243;n Jim&#233;nez&#46; D&#237;az&#44; Madrid"
            "etiqueta" => "&#42;&#42;&#42;"
            "identificador" => "aff0015"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Cytogenetical analysis of pleurai exudates of suspected malignancy"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "1979-07-19"
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="absec0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Presentamos una nueva t&#233;cnica para realizar el diagn&#243;stico de malignidad en derrames pleurales sospechosos&#46; Consiste en el an&#225;lisis citogen&#233;tico del exudado en busca de hiperdiploidia o marcadores cromos&#243;micos&#46; Se realiz&#243; la t&#233;cnica sobre 14 muestras que&#44; al tiempo&#44; fueron estudiadas desde e punto de vista citol&#243;gico e histol&#243;gico&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">En relaci&#243;n a la citolog&#237;a&#44; ambos m&#233;todos revelaron similar fiabilidad&#59; er ning&#250;n caso se obtuvieron falsos posi tivos&#44; y en 2 se hallaron falsos negati vos&#44; igual porcentaje que en la citolog&#237;a&#46; De los 9 casos tumorales estudia dos&#44; se hizo el diagn&#243;stico en 7&#59; de ellos&#44; en 6 se hall&#243; hiperdiploidia en e porcentaje que exig&#237;a nuestro criteric de malignidad&#44; y en 1 se hallaron marcadores cromos&#243;micos&#46;</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">El inter&#233;s de esta t&#233;cnica residir&#237;a er su rapidez&#44; su fiabilidad y la b&#250;squedr de marcadores cromos&#243;micos espec&#237;ficos de cada proceso tumoral&#46;</p></span>"
      ]
      "en" => array:2 [
        "titulo" => "Summary"
        "resumen" => "<span id="absec0010" class="elsevierStyleSection elsevierViewall"><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">The authors present a new techniquf for carrying out the diagnosis o malignancy in suspicious pleura exudates&#46; This technique consists ii cytogenetical analysis of the exudati searching for polyploidy or chromo somal markers&#46; This technique wa&#59; used for 14 samples which were alsc studied ar the same time from the cy tologic and histological point of view</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">In relation to cytology&#44; both methoc revealed similar trustworthiness&#59; in m case were false positives obtained&#44; bu in two cases false negatives wen found&#44; the same percentaje as that ii cytology&#46; Of the nine cases of tumor&#58; studied&#44; the diagnosis was made in 7 Of these seven&#44; polyploidy was founc in the percentage that the authors criteria of malignancy required&#44; and ii one case chromosomal markers wen found&#46;</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">The interest of this technique lies it its rapidity&#44; reliability and the searcl for specific chromosomal markers o each tumorous process&#46;</p></span>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliografia"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:20 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chromosome analyses of a human ovarian cystocarcinoma in the ascites form"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Hansen-Melander"
                            1 => "S&#46; Kullander"
                            2 => "Y&#46; Melander"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J&#46; Nati&#46; Cancer Inst&#46;"
                        "fecha" => "1956"
                        "volumen" => "16"
                        "paginaInicial" => "1067"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chromosome of human cancer cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;I&#46; Spriggs"
                            1 => "M&#46;M&#46; Boddington"
                            2 => "C&#46;M&#46; Clarke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br&#46; Med&#46; J&#46;"
                        "fecha" => "1962"
                        "volumen" => "2"
                        "paginaInicial" => "1431"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/519487"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Usefullness of chromosome examination in the diagnosis of malignant pleural effusions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Dewald"
                            1 => "D&#46;E&#46; Dines"
                            2 => "L&#46;H&#46; Weyland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM197612302952702"
                      "Revista" => array:5 [
                        "tituloSerie" => "N&#46; Engl&#46; J&#46; Med"
                        "fecha" => "1976"
                        "volumen" => "295"
                        "paginaInicial" => "1494"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/995156"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The chromosome in ontogeny and oncogeny"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "T&#46;S&#46; Hauschka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "C&#225;ncer Res"
                        "fecha" => "1961"
                        "volumen" => "21"
                        "paginaInicial" => "957"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13712320"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A Karyologic study of the cancer of the ovary and the cancer cell in the ascitic effusions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46; Slot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Neoplasma"
                        "fecha" => "1967"
                        "volumen" => "14"
                        "paginaInicial" => "3"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6031830"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnosis of malignanc by chromosome counts"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46;F&#46; Jacobs"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1961"
                        "volumen" => "2"
                        "paginaInicial" => "724"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2876192"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long acrocentric marker chromosomes in malignant effusions and solid tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46;F&#46; Benedic"
                            1 => "C&#46;D&#46; Brown"
                            2 => "I&#46;H&#46; Porter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N&#46; Y&#46; State J&#46; Med&#46;"
                        "fecha" => "1971"
                        "volumen" => "71"
                        "paginaInicial" => "952"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5280177"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chromosomes of human cancer cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;I&#46; Spriggs"
                            1 => "M&#46;M&#46; Boddington"
                            2 => "C&#46;M&#46; Clarke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br&#46; Med&#46; J"
                        "fecha" => "1962"
                        "volumen" => "2"
                        "paginaInicial" => "1431"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/519487"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The cytogenetics diagnosis of malignancy in effusions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46;F&#46; Benedic"
                            1 => "I&#46;H&#46; Porter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Acta Cytol&#46; &#40;Baltimore&#41;"
                        "fecha" => "1972"
                        "volumen" => "16"
                        "paginaInicial" => "304"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chromosome analyses of a metastatic gastro-carcinoma including quimacrine fluorescence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46; Gramberg"
                            1 => "S&#46; Gupta"
                            2 => "L&#46; Zech"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Hereditas"
                        "fecha" => "1973"
                        "volumen" => "75"
                        "paginaInicial" => "189"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4782040"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cytogenetical diagnosis of malignant pleural effusions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Hanson"
                            1 => "R&#46; Korsgaard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Scand&#46; J&#46; Respir&#46; Dis"
                        "fecha" => "1974"
                        "volumen" => "55"
                        "paginaInicial" => "301"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4142656"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cluste-ring of aberrations to specific chromosomes in human neoplasms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46; Mitelman"
                            1 => "G&#46; Levan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Hereditas"
                        "fecha" => "1976"
                        "volumen" => "82"
                        "paginaInicial" => "167"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1065624"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chromosomes and causation of human cancer and leukemias X&#58; Banding Pallerns in cancerous effusions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Katati"
                            1 => "I&#46; Hayata"
                            2 => "M&#46; Oshimura"
                            3 => "A&#46; Sandberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1975"
                        "volumen" => "36"
                        "paginaInicial" => "1729"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1192362"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clustering of aberrations to specific chromosomes in human neoplasms II Incidence and geographic distribution of chromosome aberrations in 856 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46; Mitelman"
                            1 => "G&#46; Levan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Hereditas"
                        "fecha" => "1978"
                        "volumen" => "89"
                        "paginaInicial" => "207"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/730541"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Marker chromosome 14q&#43; in folicular lymphoma in transformation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Catovsky"
                            1 => "S&#46; Pittman"
                            2 => "D&#46; Lewis"
                            3 => "E&#46; Pearse"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S2213-8587(14)70182-2"
                      "Revista" => array:5 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1977"
                        "volumen" => "2"
                        "paginaInicial" => "934"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25466722"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "cromosomes of malignanlymphomas Studies in short term cultures from lymph nodes of twenty cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46; Fleischman"
                            1 => "C&#46;H&#46; Hakansson"
                            2 => "A&#46;C&#46; Levan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Hereditas"
                        "fecha" => "1976"
                        "volumen" => "83"
                        "paginaInicial" => "47"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/786957"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human breast carcinoma&#58; marker chromosome involving lq in seven cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Q&#46;V&#46; Jones CRUCIGER"
                            1 => "S&#46; Pathax"
                            2 => "R&#46; Callian"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Cytogenet Cell Genet"
                        "fecha" => "1976"
                        "volumen" => "1"
                        "paginaInicial" => "231"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A marker in one chromosome n&#46;&#176; 14 in Burkitt lyinphoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Manolov"
                            1 => "Y&#46; Manolova"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Hereditas"
                        "fecha" => "1971"
                        "volumen" => "69"
                        "paginaInicial" => "300"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cytogenetics of malignant lymphomas studies utilising a Giemsa-banding technique"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "B&#46;R&#46; Reeves"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Hum&#46; Gen&#46;"
                        "fecha" => "1974"
                        "volumen" => "20"
                        "paginaInicial" => "231"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neo-plaltic diseases of the lungs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;G&#46; Fraser"
                            1 => "J&#46;A&#46;P&#46; Pare"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:5 [
                        "titulo" => "Diagnosis of Diseases of the chest&#58; An integrated study based on the abnormal roentgenogram"
                        "fecha" => "1970"
                        "paginaInicial" => "723"
                        "editorial" => "W&#46; B&#46; Saunders Co"
                        "editorialLocalizacion" => "Philadelphia"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/03002896/0000001600000001/v1_201509151242/S0300289615325072/v1_201509151242/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9277"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03002896/0000001600000001/v1_201509151242/S0300289615325072/v1_201509151242/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615325072?idApp=UINPBA00003Z"
]
Share
Journal Information
Vol. 16. Issue 1.
Pages 7-11 (January - March 1980)
Share
Share
Download PDF
More article options
Vol. 16. Issue 1.
Pages 7-11 (January - March 1980)
Full text access
Analisis citogenetico de exudados pleurales sospechosos de malignidad
Cytogenetical analysis of pleurai exudates of suspected malignancy
Visits
3233
L. García Quesada*, J.A. Portero Sánchez**, J.A. Cambronero Galache***
* Departamento de Genética. Fundación Jiménez. Díaz, Madrid
** Departamento de Genética. Fundación Jiménez. Díaz, Madrid
*** Departamento de Medicina Interna. Fundación Jiménez. Díaz, Madrid
This item has received
Article information
Resumen

Presentamos una nueva técnica para realizar el diagnóstico de malignidad en derrames pleurales sospechosos. Consiste en el análisis citogenético del exudado en busca de hiperdiploidia o marcadores cromosómicos. Se realizó la técnica sobre 14 muestras que, al tiempo, fueron estudiadas desde e punto de vista citológico e histológico.

En relación a la citología, ambos métodos revelaron similar fiabilidad; er ningún caso se obtuvieron falsos posi tivos, y en 2 se hallaron falsos negati vos, igual porcentaje que en la citología. De los 9 casos tumorales estudia dos, se hizo el diagnóstico en 7; de ellos, en 6 se halló hiperdiploidia en e porcentaje que exigía nuestro criteric de malignidad, y en 1 se hallaron marcadores cromosómicos.

El interés de esta técnica residiría er su rapidez, su fiabilidad y la búsquedr de marcadores cromosómicos específicos de cada proceso tumoral.

Summary

The authors present a new techniquf for carrying out the diagnosis o malignancy in suspicious pleura exudates. This technique consists ii cytogenetical analysis of the exudati searching for polyploidy or chromo somal markers. This technique wa; used for 14 samples which were alsc studied ar the same time from the cy tologic and histological point of view

In relation to cytology, both methoc revealed similar trustworthiness; in m case were false positives obtained, bu in two cases false negatives wen found, the same percentaje as that ii cytology. Of the nine cases of tumor: studied, the diagnosis was made in 7 Of these seven, polyploidy was founc in the percentage that the authors criteria of malignancy required, and ii one case chromosomal markers wen found.

The interest of this technique lies it its rapidity, reliability and the searcl for specific chromosomal markers o each tumorous process.

Full text is only aviable in PDF
Bibliografia
[1.]
E. Hansen-Melander, S. Kullander, Y. Melander.
Chromosome analyses of a human ovarian cystocarcinoma in the ascites form.
J. Nati. Cancer Inst., 16 (1956), pp. 1067
[2.]
A.I. Spriggs, M.M. Boddington, C.M. Clarke.
Chromosome of human cancer cells.
Br. Med. J., 2 (1962), pp. 1431
[3.]
G. Dewald, D.E. Dines, L.H. Weyland.
Usefullness of chromosome examination in the diagnosis of malignant pleural effusions.
N. Engl. J. Med, 295 (1976), pp. 1494
[4.]
T.S. Hauschka.
The chromosome in ontogeny and oncogeny.
Cáncer Res, 21 (1961), pp. 957
[5.]
E. Slot.
A Karyologic study of the cancer of the ovary and the cancer cell in the ascitic effusions.
Neoplasma, 14 (1967), pp. 3
[6.]
G.F. Jacobs.
Diagnosis of malignanc by chromosome counts.
Lancet, 2 (1961), pp. 724
[7.]
W.F. Benedic, C.D. Brown, I.H. Porter.
Long acrocentric marker chromosomes in malignant effusions and solid tumors.
N. Y. State J. Med., 71 (1971), pp. 952
[8.]
A.I. Spriggs, M.M. Boddington, C.M. Clarke.
Chromosomes of human cancer cells.
Br. Med. J, 2 (1962), pp. 1431
[9.]
W.F. Benedic, I.H. Porter.
The cytogenetics diagnosis of malignancy in effusions.
Acta Cytol. (Baltimore), 16 (1972), pp. 304
[10.]
L. Gramberg, S. Gupta, L. Zech.
Chromosome analyses of a metastatic gastro-carcinoma including quimacrine fluorescence.
Hereditas, 75 (1973), pp. 189
[11.]
A. Hanson, R. Korsgaard.
Cytogenetical diagnosis of malignant pleural effusions.
Scand. J. Respir. Dis, 55 (1974), pp. 301
[12.]
F. Mitelman, G. Levan.
Cluste-ring of aberrations to specific chromosomes in human neoplasms.
Hereditas, 82 (1976), pp. 167
[13.]
S. Katati, I. Hayata, M. Oshimura, A. Sandberg.
Chromosomes and causation of human cancer and leukemias X: Banding Pallerns in cancerous effusions.
Cancer, 36 (1975), pp. 1729
[14.]
F. Mitelman, G. Levan.
Clustering of aberrations to specific chromosomes in human neoplasms II Incidence and geographic distribution of chromosome aberrations in 856 cases.
Hereditas, 89 (1978), pp. 207
[15.]
D. Catovsky, S. Pittman, D. Lewis, E. Pearse.
Marker chromosome 14q+ in folicular lymphoma in transformation.
[16.]
T. Fleischman, C.H. Hakansson, A.C. Levan.
cromosomes of malignanlymphomas Studies in short term cultures from lymph nodes of twenty cases.
Hereditas, 83 (1976), pp. 47
[17.]
Q.V. Jones CRUCIGER, S. Pathax, R. Callian.
Human breast carcinoma: marker chromosome involving lq in seven cases.
Cytogenet Cell Genet, 1 (1976), pp. 231
[18.]
G. Manolov, Y. Manolova.
A marker in one chromosome n.° 14 in Burkitt lyinphoma.
Hereditas, 69 (1971), pp. 300
[19.]
B.R. Reeves.
Cytogenetics of malignant lymphomas studies utilising a Giemsa-banding technique.
Hum. Gen., 20 (1974), pp. 231
[20.]
R.G. Fraser, J.A.P. Pare.
Neo-plaltic diseases of the lungs.
Diagnosis of Diseases of the chest: An integrated study based on the abnormal roentgenogram, W. B. Saunders Co, (1970), pp. 723
Copyright © 1980. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?