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Vol. 47. Issue S1.
Hot topics 2010 en enfermedades respiratorias
Pages 27-32 (January 2011)
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Vol. 47. Issue S1.
Hot topics 2010 en enfermedades respiratorias
Pages 27-32 (January 2011)
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Tratamiento del cáncer de pulmón con invasión de la pared torácica
Treatment of lung cancer with chest wall invasion
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Ignacio Muguruzaa, José Luis Arandab, Mariano García-Yustec,
Corresponding author
mgyuste2@hotmail.com

Autor para correspondencia.
a Servicio de Cirugía Torácica, Hospital Universitario Ramón y Cajal, Madrid, España
b Servicio de Cirugía Torácica, Hospital Clínico Universitario, Salamanca, España
c Servicio de Cirugía Torácica, Hospital Clínico Universitario, Valladolid, España
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El objetivo de este trabajo es analizar en pacientes afectados de cáncer de pulmón con invasión de la pared torácica, la indicación y el carácter multidisciplinar del tratamiento, y los métodos y problemas técnicos que plantea la reconstrucción parietal.

La invasión de la pared torácica por contigüidad afecta al 5% de los pacientes con un carcinoma broncogénico. Determinar de forma preoperatoria su existencia facilita el correcto planteamiento terapéutico. La tomografía por emisión de positrones en combinación con las imágenes anatómicas (PET/TC) permite un mejor estudio del factor T y de la extensión metastásica ganglionar y a distancia. Como norma, el tratamiento quirúrgico debe intentar una exéresis tumoral completa: lobectomía, resección de pleura parietal y/o de la pared torácica, asegurando márgenes libres de tumor, y linfadenectomía hiliar y mediastínica. En relación con la supervivencia, se analizan distintos factores pronósticos. La indicación de un tratamiento oncológico de inducción o adyuvante también se considera.

Reconstruir la pared torácica supone devolver la caja torácica y los músculos que la rodean a la situación más anatómica y fisiológica posible. La reconstrucción ideal ha de conseguir una adecuada estabilidad y cobertura parietales para preservar su funcionalidad, y es importante aunque secundario el resultado cosmético. Existen muchos materiales disponibles para realizar la reparación, debiendo adecuarse su uso a cada caso en particular. Resulta fundamental un equipo multidisciplinar capaz de planificar y llevar a cabo la resección y posterior reconstrucción, controlar el postoperatorio y tratar de forma precoz las complicaciones.

Palabras clave:
Cáncer de pulmón
Invasión pared torácica
Reconstrucción pared torácica
Abstract

The aim of this study was to analyze chest wall invasion, the indication and multidisciplinary nature of treatment, the methods used for parietal reconstruction and the technical problems posed by this procedure in patients with lung cancer and chest wall invasion.

Chest wall invasion from adjacent malignancies affects 5% of patients with a bronchogenic carcinoma. Preoperative determination of parietal invasion aids the planning of an appropriate therapeutic approach. Positron emission tomography combined with computed tomography (PET/CT) improves the study of T-factor and metastatic nodal involvement and distant metastases. As a rule, surgical treatment should attempt complete tumoral resection: lobectomy, resection of the parietal pleura and/or of the chest wall –ensuring tumor-free margins– and hilar and mediastinal lymphadenectomy. We also analyzed the distinct prognostic factors for survival, as well as the indication for induction or adjuvant therapy.

Chest wall reconstruction involves recreating the most anatomical and physiological conditions possible in the chest cavity and surrounding muscles. The ideal reconstruction would achieve adequate parietal stability and coverage to preserve functionality, with the cosmetic result being an important, but secondary, consideration. Many materials are available for reconstruction and the choice of material should be individualized in each patient. A multidisciplinary team able to plan and perform the resection and subsequent reconstruction, oversee postoperative management and treat complications early is essential.

Keywords:
Lung cancer
Chest wall invasion
Chest wall reconstruction
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Bibliografía
[1.]
F.P. Coleman.
Primary carcinoma of lung with invasion of the ribs: Pneumonectomy and simultaneous bloc resection of chest wall.
Ann Surg, 126 (1947), pp. 156-158
[2.]
H.C. Grillo, J.J. Greenberg, E.W. Wilkins.
Resection of bronchogenic carcinoma involving thoracic wall.
J Thorac Cardiovasc Surg, 51 (1966), pp. 417-421
[3.]
A.S. Geha, P.E. Bernatz, L.B. Woolner.
Bronchogenic carcinoma involving the thoracic Wall. Surgical treatment and prognostic significance.
J Thorac Cardiovasc Surg, 54 (1967), pp. 394-402
[4.]
J.M. Piehler, P.C. Pairolero, L.H. Weiland, K.P. Offord, W.S. Payne, P.E. Bernatz.
Bronchogenic carcinoma with chest wall invasion. Factors affecting survival following en bloc resection.
Ann Thorac Surg, 34 (1982), pp. 684-691
[5.]
B.C. McCaughan, N. Martini, M.S. Bains, P.M. McCormack.
Chest wall invasion in carcinoma of the lung. Therapeutic and prognostic implications.
J Thorac Cardiovasc Surg, 89 (1985), pp. 836-841
[6.]
M.S. Allen, D.J. Mathisen, H.C. Grillo, J.C. Wain, A.C. Moncure, A.D. Hilgenberg.
Bronchogenic carcinoma with chest wall invasion.
Ann Thorac Surg, 51 (1991), pp. 948-951
[7.]
M. Albertucci, T.R. DeMeester, M. Rothberg, J.A. Hagen, R. Santoscoy, T.C. Smyrk.
Surgery in the management of peripheral lung tumors adherent to the parietal pleura.
J Thorac Cardiovasc Surg, 103 (1992), pp. 8-13
[8.]
M. Casillas, F. París, V. Tarazona, J. Padilla, M. Paniagua, G. Galán.
Surgical treatment of lung carcinoma involving the chest wall.
Eur J Cardiothorac Surg, 3 (1989), pp. 425-429
[9.]
L. López, J. López Pujol, A. Varela, C. Baamonde, C. Socas, A. Salvatierra, et al.
Surgical treatment of Stage II non.small cell carcinoma involving the chest wall.
Scand J Thorac Surg, 26 (1992), pp. 129-133
[10.]
R.J. Downey, N. Martini, V.W. Rusch, M.S. Bains, R.J. Korst, R.J. Ginsberg.
Extent of chest wall invasion and survival in patients with lung cancer.
Ann Thorac Surg, 68 (1999), pp. 188-193
[11.]
C. Deschamps, B.M. Tirnaksiz, R. Darbandi, V.F. Trastek, M.S. Allen, D.L. Miller, et al.
Early and long-term results of prosthetic chest wall reconstruction.
J Thorac Cardiovasc Surg, 117 (1999), pp. 588-591
[12.]
H.M. Burkhart, M.S. Allen, F.C. Nichols III, C. Deschamps, D.L. Miller, V.F. Trastek, et al.
Results of en bloc resection for bronchogenic carcinoma with chest wall invasion.
J Thorac Cardiovasc Surg, 123 (2002), pp. 670-675
[13.]
H. Matsuoka, W. Nishio, M. Okada, T. Sakamoto, M. Yoshimura, N. Tsubota.
Resection of chest wall in patients with non-small cell lung cancer.
Eur J Cardiothorac Surg, 26 (2004), pp. 1200-1204
[14.]
C. Doddoli, B. D’Journo, F. Le Pimpec-Barthes, A. Dujon, C. Foucault, P. Thomas, et al.
Lung cancer invading the chest wall: a plea for en-bloc resection but the need for new treatment strategies.
Ann Thorac Surg, 80 (2005), pp. 2032-2040
[15.]
L. Voltolini, C. Rapicetta, L. Luzzi, C. Ghiribelli, T. Ligabue, P. Paladín, et al.
Lung cancer with chest wall involvement: Predictive factors of long-term survival after surgical resection.
Lung Cancer, 52 (2006), pp. 359-364
[16.]
L.E. Quint.
Lung cancer: assessing ressectability.
Cancer Imaging, 4 (2003), pp. 15-18
[17.]
D. Lardinois, W. Weder, T.F. Hany, E.M. Kamel, S. Korom, B. Seifert, et al.
Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomography.
N Engl J Med, 348 (2003), pp. 2500-2507
[18.]
S.C. Rankin.
Advances in radiological staging of non-small cell lung cancer (NSCLC).
Cancer Imaging, 4 (2004), pp. S22-S24
[19.]
C.D. Collins.
PET/CT in oncology: for which tumours is it the reference standard?.
Cancer Imaging, 7 (2007), pp. S77-87
[20.]
K.R. Shen, B.F. Meyers, J.M. Larner, D. Jones.
Guidelines (2nd Edition) ACCP Evidence-Based Clinical Practice. Special Treatment Issues in Lung Cancer.
Chest, 132 (2007), pp. 290S-305
[21.]
National Institute for Clinical Excellence. Clinical Guideline 24. Lung cancer: the diagnosis and treatment of lung cancer. Published by the National Institute for Clinical Excellence. Disponible en: www.nice.org.uk. NICE 2005.
[22.]
P. Magdeleinat, M. Alifano, C. Benbrahem, L. Spaggiari, C. Porello, P. Puyo, et al.
Surgical treatment of lung cancer invading the chest wall: results and prognostic factors.
Ann Thorac Surg, 71 (2001), pp. 1094-1099
[23.]
S. Elia, S. Griffo, M. Gentile, R. Costabile, G. Ferrante.
Surgical treatment oflung cancer invading chest wall: a retrospective analysis of 110 patients.
Eur J Cardiothorac Surg, 20 (2001), pp. 356-360
[24.]
F. Facciolo, G. Cardillo, M. Lopergolo, G. Pallone, F. Sera, M. Martelli.
Chest wall invasion in non-small cell lung carcinoma: a rational for en bloc resection.
J Thorac Cardiovasc Surg, 121 (2001), pp. 645-656
[25.]
N. Suzuki, T. Saitoh, S. Kitamura.
Tumour invasion of the chest wall in lung cancer: diagnosis with US.
[26.]
S. Akata, N. Kajiwara, J. Park, M. Yoshimura, D. Kakizaki, K. Abe, et al.
Evaluation of chest wall invasion by lung cancer using respiratory dynamic MRI.
J Med Imaging Radiat Oncol, 52 (2008), pp. 36-38
[27.]
N. Kajiwara, S. Akata, O. Uchida, J. Usuda, T. Ohira, N. Kawate, et al.
Cine MRI enables better therapeutic planning than CT in cases of possible lung cancer chest wall invasion.
Lung Cancer, 69 (2010), pp. 203-208
[28.]
P. Uhrmeister, K.H. Allmann, H. Wertzel, C. Altehoefer, J. Laubenberger, J. Hasse, et al.
Chest wall infiltration by lung cancer: value of thin sectional CT with different reconstruction algorithms.
Eur Radiol, 9 (1999), pp. 1304-1309
[29.]
V. Bandi, W. Lunn, A. Ernst, R. Eberhardt, H. Hoffmann, F.J.F. Herth.
Ultrasoundvs computed tomography in detecting chest wall invasion by tumour: a prospective study.
Chest, 133 (2008), pp. 881-886
[30.]
G. Gallardo-Valera, A. Triviño-Ramírez, M. Congregado, R. Jiménez-Merchán, F.J. Ayarra Jarné, J. Loscertales.
Utilidad de la videotoracoscopia para una correcta estadificación de tumores T3 por invasión de pared.
Arch Bronconeumol, 45 (2009), pp. 325-329
[31.]
G. Roviaro, F. Varoli, F. Grignani, C. Vergani, C. Pagano, M. Maciocco, et al.
Non-small cell lung cancer with chest wall invasion: evolution of surgical treatment and prognosis in the last 3 decades.
Chest, 123 (2003), pp. 1341-1347
[32.]
A. Chapelier, E. Fadel, P. Macchiarini, B. Lenot, F. Le Roy Ladurie, et al.
Factors affecting long-term survival after en-bloc resection of lung cancer invading the chest wall.
Eur J Cardiothorac Surg, 18 (2000), pp. 513-518
[33.]
H. Akay, A.K. Cangir, H. Kutlay, S. Kavukçu, I. Okten, S. Yavuzer.
Surgical treatment of peripheral lung cancer adherent to parietal pleura.
Eur J Cardiothorac Surg, 22 (2002), pp. 615-620
[34.]
T.C. Mineo, V. Ambrogi, E. Pompeo, A. Balde.
Immunohistochemistry-detected microscopic tumor spread affects outcome in en-bloc resection for T3-chest wall lung cancer.
Eur J Cardiothorac Surg, 31 (2007), pp. 1120-1124
[35.]
E. Stoelben, C. Ludwig.
Chest wall resection for lung cancer: indications and techniques.
Eur J Cardiothorac Surg, 35 (2009), pp. 450-456
[36.]
N. Novoa, P. Benito, M.F. Jiménez, A. De Juan, J. Luis Aranda, G. Varela.
Reconstruction of chest wall defects after resection of large neoplasms: ten-year experience.
Interact Cardiovasc Thorac Surg, 4 (2005), pp. 250-255
[37.]
D.T. Netscher, M.A. Baumholtz.
Chest reconstruction: I. Anterior and anterolateral chest wall and wounds affecting respiratory function.
Plast Reconstr Surg, 124 (2009), pp. 240e-e252
[38.]
A. Losken, V.H. Thourani, G.W. Carlson, G.E. Jones, J.H. Culbertson, J.I. Miller, et al.
A reconstructive algorithm for plastic surgery following extensive chest wall resection.
Br J Plast Surg, 57 (2004), pp. 295-302
[39.]
G. Graeber, et al.
Chest wall and sternum resection and reconstruction.
pp. 1306-1328
[40.]
T. Iarussi, A. Pardolesi, P. Camplese, R. Sacco.
Composite chest wall reconstruction using titanium plates and mesh preserves chest wall function.
J Thorac Cardiovasc Surg, 7 (2009), pp. 7
[41.]
A.M. Hamad, G. Marulli, R. Bulf, F. Rea.
Titanium plates support for chest wall reconstruction with Gore-Tex dual mesh after sternochondral resection.
Eur J Cardiothorac Surg, 36 (2009), pp. 779-780
[42.]
A.S. Coonar, N. Qureshi, I. Smith, F.C. Wells, E. Reisberg, J.M. Wihlm.
A novel titanium rib bridge system for chest wall reconstruction.
Ann Thorac Surg, 87 (2009), pp. e46-e48
[43.]
A. Watanabe, T. Watanabe, T. Obama, H. Ohsawa, T. Mawatari, Y. Ichimiya, et al.
New material for reconstruction of the anterior chest wall, including the sternum.
J Thorac Cardiovasc Surg, 126 (2003), pp. 1212-1214
[44.]
T.A. Pedersen, H.K. Pilegaard.
Reconstruction of the thorax with Ley prosthesis after resection of the sternum.
Ann Thorac Surg, 87 (2009), pp. e31-e33
[45.]
A. Gonfiotti, P.F. Santini, D. Campanacci, M. Innocenti, S. Ferrarello, A. Caldarella, et al.
Malignant primary chest-wall tumours: techniques of reconstruction and survival.
Eur J Cardiothorac Surg, 38 (2010), pp. 39-45
[46.]
P.G. Arnold, P.C. Pairolero.
Chest-wall reconstruction: an account of 500 consecutive patients.
Plast Reconstr Surg, 98 (1996), pp. 804-810
[47.]
D.L. Larson, M.J. McMurtrey.
Musculocutaneous flap reconstruction of chest-wall defects: an experience with 50 patients.
Plast Reconstr Surg, 73 (1984), pp. 734-740
[48.]
L.J. Kohman, J.H. Auchincloss, R. Gilbert, M. Beshara.
Functional results of muscle flap closure for sternal infection.
Ann Thorac Surg, 52 (1991), pp. 102-106
[49.]
J.A. Meadows 3rd, B.A. Staats, P.C. Pairolero, J.R. Rodarte, P.G. Arnold.
Effect of resection of the sternum and manubrium in conjunction with muscle transposition on pulmonary function.
Mayo Clin Proc, 60 (1985), pp. 604-609
[50.]
O.J. Cicilioni Jr, F.H. Stieg 3rd, G. Papanicolaou.
Sternal wound reconstruction with transverse plate fixation.
Plast Reconstr Surg, 115 (2005), pp. 1297-1303
[51.]
D. Lardinois, M. Müller, M. Furrer, A. Banic, M. Gugger, T. Krueger, et al.
Functional assessment of chest wall integrity after methylmethacrylate reconstruction.
Ann Thorac Surg, 69 (2000), pp. 919-923
[52.]
B. Wiegmann, P. Zardo, N. Dickgreber, F. Länger, C. Fegbeutel, A. Haverich, et al.
Biological materials in chest wall reconstruction: initial experience with the Peri-Guard Repair Patch.
Eur J Cardiothorac Surg, 37 (2010), pp. 602-605
[53.]
C.C. Cothren, K. Gallego, E.D. Anderson, D. Schmidt.
Chest wall reconstruction with acellular dermal matrix (AlloDerm) and a latissimus muscle flap.
Plast Reconstr Surg, 114 (2004), pp. 1015-1017
[54.]
D.W. Tuggle, P.C. Mantor, D.S. Foley, M.M. Markley, N. Puffinbarger.
Using a bioabsorbable copolymer plate for chest wall reconstruction.
J Pediatr Surg, 39 (2004), pp. 626-628
[55.]
J.L. Aranda, G. Varela, P. Benito, A. Juan.
Donor cryopreserved rib allografts for chest wall reconstruction.
Interact Cardiovasc Thorac Surg, 7 (2008), pp. 858-860
[56.]
G. Marulli, A.M. Hamad, E. Cogliati, C. Breda, A. Zuin, F. Rea.
Allograft sternochondral replacement after resection of large sternal chondrosarcoma.
J Thorac Cardiovasc Surg, 139 (2010), pp. e69-e70
[57.]
S. Nazari.
Transcervical approach (Dartevelle technique) for resection of lung tumors invading the thoracic inlet, sparing the clavicle.
J Thorac Cardiovasc Surg, 112 (1996), pp. 558-560
[58.]
M.T. Jaklitsch, A. Rego.
Endorsement for sparing the clavicle in the transcervical approach to the thoracic inlet.
J Thorac Cardiovasc Surg, 113 (1997), pp. 959-961
[59.]
D. Grunenwald, L. Spaggiari, P. Girard, P. Baldeyrou.
Transmanubrial approach to the thoracic inlet.
J Thorac Cardiovasc Surg, 113 (1997), pp. 958-959
[60.]
L.W. Martin, G.L. Walsh.
Vertebral body resection.
Thorac Surg Clin, 14 (2004), pp. 241-254
[61.]
Universal Clamp System. Disponible en: http://www.zimmerspine.eu/z/ctl/op/global/action/1/id/10239/template/MP/navid/10244. Zimmer Spine Europe, Inc., 2010.
[62.]
J.C. Wittig, J. Bickels, F. Wodajo, K.L. Kellar-Graney, M.M. Malawer.
Constrained total scapula reconstruction after resection of a high-grade sarcoma.
Clin Orthop Relat Res, (2002), pp. 143-155
[63.]
T. Pritsch, J. Bickels, C.C. Wu, M.H. Squires, M.M. Malawer.
Is scapular endoprosthesis functionally superior to humeral suspension?.
Clin Orthop Relat Res, 456 (2007), pp. 188-195
[64.]
B.R. Moelleken, S.A. Mathes, N. Chang.
Latissimus dorsi muscle-musculocutaneous flap in chest-wall reconstruction.
Surg Clin North Am, 69 (1989), pp. 977-990
[65.]
R.J. Skoracki, D.W. Chang.
Reconstruction of the chestwall and thorax.
J Surg Oncol, 94 (2006), pp. 455-465
[66.]
J.C. Yuen, A.T. Zhou, D. Serafin, G.S. Georgiade.
Long-term sequelae following median sternotomy wound infection and flap reconstruction.
Ann Plast Surg, 35 (1995), pp. 585-589
[67.]
J.H.t. Boehmler, C.E. Butler, J. Ensor, S.J. Kronowitz.
Outcomes of various techniques of abdominal fascia closure after TRAM flap breast reconstruction.
Plast Reconstr Surg, 123 (2009), pp. 773-781
[68.]
T.F. Molnar, J.E. Pongracz.
Tissue engineering and biotechnology in general thoracic surgery.
Eur J Cardiothorac Surg, 37 (2010), pp. 1402-1410
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