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Vol. 61. Issue 10.
Pages 603-609 (October 2025)
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Vol. 61. Issue 10.
Pages 603-609 (October 2025)
Original Article
Pulmonary Rehabilitation in Patients With Post-Tuberculosis Lung Disease: A Prospective Multicentre Study
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Denise Rossato Silvaa, Fernanda Carvalho de Queiroz Mellob, Tatiana Senna Galvãoc, Margareth Dalcolmod, Ana Paula Cere dos Santose, Diego de Faria Magalhães Torresf, Larissa Andre de Meirelles Café de Jesusc, Dina Viscag,h, Rosella Centisi, Lia D’Ambrosioj, Anh Tuan Dinh-Xuank, Giovanni Battista Migliorii,
a Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
b Instituto de Doenças do Tórax, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
c Universidade Federal da Bahia, Salvador, Brazil
d Centro de Referência Hélio Fraga, Fiocruz, Rio de Janeiro, Brazil
e Programa de Pós-Graduação em Ciências Pneumológicas da UFRGS, Porto Alegre, Brazil
f Hospital Universitário Clementino Fraga Filho, UFRJ, Rio de Janeiro, Brazil
g Department of Medicine and Cardiopulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy
h Department of Medicine and Surgery, University of Insubria, Varese, Italy
i Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri, IRCCS, Tradate, Italy
j Public Health Consulting Group, Lugano, Switzerland
k Department of Respiratory and Sleep Medicine, Cochin Hospital, University Paris Cité, 27 rue du faubourg Saint-Jacques, 75014 Paris, France
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Figures (2)
Tables (5)
Table 1. Characteristics of the Study Population.
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Table 2. Comparison of Pulmonary Function Tests Between Groups 1 (Rehabilitation) and 2 (No Rehabilitation).
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Table 3. Comparison of Pulmonary Function Tests Between COPD and No COPD Patients Who Underwent Rehabilitation.
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Table 4. Comparison of Pulmonary Function Tests Between COPD and No COPD Patients Who Did Not Underwent Rehabilitation.
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Table 5. Comparison of pulmonary function tests according to COPD severity in Groups 1 and 2.
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Abstract
Introduction

The majority of the studies on pulmonary rehabilitation (PR) in post-tuberculosis lung disease (PTLD) were from a single center, had a low sample size and/or did not allow a complete functional evaluation before and after PR program (PRP). The objective of this study was to evaluate if PTLD patients had benefits from PR in a large collaborating multicentre study conducted in reference centers in Brazil, Italy and France.

Methods

PTLD patients underwent a comprehensive 5-week PRP (Group 1), and were compared with non-rehabilitated patients (Group 2). Pulmonary function tests, 6-minute walk test (6MWT), and arterial blood gas analysis were measured two times: before and at the end of the PRP (Group 1), and at the beginning of the follow-up and after 3 months (Group 2).

Results

Eighty-five patients were included in Group 1 and 96 patients in Group 2. Several functional parameters improved after rehabilitation, such as forced expiratory volume in one second (FEV1), forced vital capacity (FVC), diffusing capacity of the lung for carbon monoxide (DLCO), distance walked in 6MWT, the initial and final SaO2 at 6MWT. In Group 2, several functional parameters decreased after 3 months.

Conclusions

We demonstrated the benefits from PRP in patients with PTLD, including improvements in lung function and in exercise capacity. National TB programs should ensure the availability of accessible and quality post-treatment PRP for PTLD patients.

Keywords:
Tuberculosis
Mycobacterium tuberculosis
Post-tuberculosis lung disease
Pulmonary rehabilitation
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