Pulmonary Rehabilitation in Patients With Post-Tuberculosis Lung Disease: A Prospective Multicentre Study

Silva, Denise Rossato; Mello, Fernanda Carvalho de Queiroz; Galvão, Tatiana Senna; Dalcolmo, Margareth; dos Santos, Ana Paula Cere; Torres, Diego de Faria Magalhães; de Jesus, Larissa Andre de Meirelles Café; Visca, Dina; Centis, Rosella; D’Ambrosio, Lia; Dinh-Xuan, Anh Tuan; Migliori, Giovanni Battista

doi:10.1016/j.arbres.2025.02.007

Archivos de Bronconeumología

ISSN: 0300-2896

Archivos de Bronconeumologia is an international journal that publishes original studies whose content is based upon results of research initiatives dealing with several aspects of respiratory medicine including epidemiology, respiratory physiology, pathophysiology of respiratory diseases, clinical management, thoracic surgery, pediatric lung diseases, respiratory critical care, respiratory allergy and translational research. Other types of articles such as editorials, reviews, and different types of letters are also published in the journal. Additionally, the journal expresses the voice of the following scientific societies: the Spanish Respiratory Society of Pneumology and Thoracic Surgery (SEPAR; https://www.separ.es/), the Latin American Thoracic Society (ALAT; https://alatorax.org/), and the Iberian American Association of Thoracic Surgery (AIACT; http://www.aiatorax.com/).

It is a monthly journal in which all manuscripts are sent to peer-review and handled by the editor or an associate editor from the team and the final decision is made on the basis of the comments from the expert reviewers and the editors. The journal is published solely in English. All the published data is composed of novel manuscripts not previously published in any other journal and not being in consideration for publication in any other journal..

The journal is indexed at Science Citation Index Expanded, Medline/Pubmed, Embase and SCOPUS. Access to any published article is possible through the journal's web page as well as from Pubmed, ScienceDirect, and other international databases. Furthermore, the journal is also present in X, Facebook and Linkedin. Manuscripts can be submitted electronically using the following web site: https://www.editorialmanager.com/ARBR/.

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Medline, Science Citation Index Expanded (SCIE)

Denise Rossato Silvaa, Fernanda Carvalho de Queiroz Mellob, Tatiana Senna Galvãoc, Margareth Dalcolmod, Ana Paula Cere dos Santose, Diego de Faria Magalhães Torresf, Larissa Andre de Meirelles Café de Jesusc, Dina Viscag,h, Rosella Centisi, Lia D’Ambrosioj, Anh Tuan Dinh-Xuank, Giovanni Battista Migliorii,

a Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

b Instituto de Doenças do Tórax, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil

c Universidade Federal da Bahia, Salvador, Brazil

d Centro de Referência Hélio Fraga, Fiocruz, Rio de Janeiro, Brazil

e Programa de Pós-Graduação em Ciências Pneumológicas da UFRGS, Porto Alegre, Brazil

f Hospital Universitário Clementino Fraga Filho, UFRJ, Rio de Janeiro, Brazil

g Department of Medicine and Cardiopulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy

h Department of Medicine and Surgery, University of Insubria, Varese, Italy

i Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri, IRCCS, Tradate, Italy

j Public Health Consulting Group, Lugano, Switzerland

k Department of Respiratory and Sleep Medicine, Cochin Hospital, University Paris Cité, 27 rue du faubourg Saint-Jacques, 75014 Paris, France

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Figures (2)

Tables (5)

Table 1. Characteristics of the Study Population.

Table 2. Comparison of Pulmonary Function Tests Between Groups 1 (Rehabilitation) and 2 (No Rehabilitation).

Table 3. Comparison of Pulmonary Function Tests Between COPD and No COPD Patients Who Underwent Rehabilitation.

Table 4. Comparison of Pulmonary Function Tests Between COPD and No COPD Patients Who Did Not Underwent Rehabilitation.

Table 5. Comparison of pulmonary function tests according to COPD severity in Groups 1 and 2.

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Abstract

Introduction

The majority of the studies on pulmonary rehabilitation (PR) in post-tuberculosis lung disease (PTLD) were from a single center, had a low sample size and/or did not allow a complete functional evaluation before and after PR program (PRP). The objective of this study was to evaluate if PTLD patients had benefits from PR in a large collaborating multicentre study conducted in reference centers in Brazil, Italy and France.

Methods

PTLD patients underwent a comprehensive 5-week PRP (Group 1), and were compared with non-rehabilitated patients (Group 2). Pulmonary function tests, 6-minute walk test (6MWT), and arterial blood gas analysis were measured two times: before and at the end of the PRP (Group 1), and at the beginning of the follow-up and after 3 months (Group 2).

Results

Eighty-five patients were included in Group 1 and 96 patients in Group 2. Several functional parameters improved after rehabilitation, such as forced expiratory volume in one second (FEV1), forced vital capacity (FVC), diffusing capacity of the lung for carbon monoxide (DLCO), distance walked in 6MWT, the initial and final SaO2 at 6MWT. In Group 2, several functional parameters decreased after 3 months.

Conclusions

We demonstrated the benefits from PRP in patients with PTLD, including improvements in lung function and in exercise capacity. National TB programs should ensure the availability of accessible and quality post-treatment PRP for PTLD patients.

Keywords:

Tuberculosis

Mycobacterium tuberculosis

Post-tuberculosis lung disease

Pulmonary rehabilitation

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