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Vol. 32. Issue 10.
Pages 527-534 (December 1996)
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Vol. 32. Issue 10.
Pages 527-534 (December 1996)
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Mecanismos de acción de los glucocorticoides. Aplicación al tratamiento de la inflamación respiratoria
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J. Mullol*,**,1, L. Pujols**, C. Picado*,**
* Servicio de Neumología. Departament de Medicina. Universitat de Barcelona. Barcelona
** Servicio de Alergia Respiratoria. Fundació Clínic per a la Recerca Biomédica. Hospital Clínic i Universitari. Departament de Medicina. Universitat de Barcelona
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Bibliografía
[1.]
T. Addison.
On the constitutional and local effects of disease of the suprarenal capsules.
Samuel Highley, (1855),
[2.]
R.P. Schleimer.
Glucocorticosteroids. Their mechanisms of action and use in allergic diseases..
Allergy. Principies and Practice, pp. 893-925
[3.]
H. Cushing.
The basophil adenomas of the pituitary body and their clinical manifestations.
Bull Johns Hopkins Hosp, 50 (1932), pp. 137-195
[4.]
E.B. Astwood, M.S. Raben, R.W. Payne.
Chemistry of corticotrophin.
Recent Prog Horm Res, 7 (1952), pp. 1-57
[5.]
G.W. Harris.
Neural control of the pituitary gland.
Physiol Rev, 28 (1948), pp. 139-179
[6.]
W. Vale, J. Spiess, C. Rivier, J. Rivier.
Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin.
Science, 213 (1981), pp. 1.394-1.397
[7.]
P.S. Hensch, E.C. Kendall, C.H. Slocumb, H.F. Polley.
The effect of a hormone of the adrenal cortex (17-hydroxy-l1-dehydrocorticosterone; compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis.
Proc Staff Meet Mayo Clinic, 24 (1949), pp. 181-197
[8.]
P. Schimmer, K.L. Parker.
Adrenocorticotropic hormone: adrenocortical steroids and their synthetic analogs; inhibitor of the synthesis and actions of adrenocortical hormones.
Goodman & Gilman's the pharmacological basis of therapeutics, pp. 1.459-1.485
[9.]
N.V. Esteban, T. Loughlin, A.L. Yergey, J.K. Zawadzki, J.D. Booth, J.C. Winterer, et al.
Daily cortisol production rate in man determined by stable isotope dilution/mass spectrometry.
J Clin Endocrinol Metab, 72 (1991), pp. 39-45
[10.]
P.J. Barnes, S. Pedersen.
Efficacy and safety of inhaled corticosteroids in asthma.
Am Rev Respir Dis, 148 (1993), pp. 1-26
[11.]
R. Fuller, M. Johnson, A. Bye.
Fluticasone propionate: an update on preclinical and clinical experience.
Resp Med, 89 (1995), pp. 3-18
[12.]
D. Picard, K.R. Yamamoto.
Two signáis mediate hormone-dependent nuclear localization of the glucocorticoid receptor.
EMBO J, 6 (1987), pp. 3.333-3.340
[13.]
A.C. Wikstrom, O. Bakke, S. Okret, M. Brönnegärd, J.A. Gustafsson.
Intracellular localisation of the glucocorticoid receptor: evidence for cytoplasmic and nuclear localisation.
Endocrinology, 120 (1987), pp. 1.232-1.242
[14.]
R.M. Evans.
The steroid and thyroid hormone receptor superfamily.
Science, 247 (1988), pp. 889-895
[15.]
S.M. Hollenberg, C. Weinberger, E.S. Ong, G. Cerelli, A. Oro, R. Lebo, et al.
Primary structure and expression of a functional human glucocorticoid receptor cDNA.
Nature, 318 (1985), pp. 635-641
[16.]
I.J. Encío, S.D. Detera-Wadleigh.
The genomic structure of the human glucocorticoid receptor.
J Biol Chem, 266 (1991), pp. 7.182-7.188
[17.]
V. Ciguère, S.M. Hollenberg, M.G. Rosenfield, R.M. Evans.
Functional domains of the human glucocorticoid receptor.
Cell, 46 (1986), pp. 645-652
[18.]
S.M. Hollenberg, R.M. Evans.
Múltiple and cooperative trans-activation domains of the human glucocorticoid receptor.
Cell, 55 (1988), pp. 899-906
[19.]
K. Dahlman-Wright, T. Almlof, I.J. McEwan, J.A. Gustafsson, A.P.H. Wright.
Delineation of a small región within the major transactivation domain of the human glucocorticoid receptor that mediates transactivation of gene expression.
Proc Natl Acad Sci USA, 91 (1994), pp. 1.619-1.623
[20.]
M. Rexin, W. Busch, U. Gehring.
Protein components of the nonactivated glucocorticoids receptor.
J Biol Chem, 266 (1991), pp. 24.601-24.605
[21.]
J.A. Cidlowski, N.B. Cidlowski.
Regulation of glucocorticoid receptors by glucocorticoids in cultured HeLa S, cells.
Endocrinology, 109 (1981), pp. 1.975-1.981
[22.]
S. Rosewicz, A.R. McDonald, B.A. Maddux, I.D. Goldfine, R.L. Miesfield, C.D. Logsdon.
Mechanism of glucocorticoid receptor down-regulation by glucocorticoids.
J Biol Chem, 263 (1988), pp. 2.581-2.584
[23.]
K.L. Burnstein, C.M. Jewell, M. Sar, J.A. Cidlowski.
Intragenic sequences of the human glucocorticoid receptor complementary DNA mediate hormone-inducible receptor messenger RNA downregulation through multiple mechanisms.
Mol Endocrinol, 8 (1994), pp. 1.764-1.773
[24.]
G. Baughman, M.T. Harrigan, N.F. Campbell, S.J. Nurrish, S. Bourgeois.
Genes newly identified as regulated by glucocorticoids in murine thymocytes.
Mol Endocrinol, 5 (1991), pp. 637-644
[25.]
M.I. Diamond, J.N. Miner, S.K. Yoshinaga, K.R. Yamamoto.
Transcription factor interactions: selectors of positive or negative regulation from a single DNA element.
Science, 249 (1990), pp. 1.266-1.272
[26.]
P.J. Barnes, A.P. Greening, G.K. Crompton.
Glucocorticoid resistance in asthma.
Am J Respir Crit Care Med, 152 (1995), pp. 5.125-5.142
[27.]
S.M. Grimm, P.A. Baeurle.
The inducible transcription factor NF-kB: structure-function relationship of its protein subunits.
Biochem J, 290 (1993), pp. 297-308
[28.]
T. Kishimoto, R. Taga, S. Akira.
Cytokine signal transduction.
Cell, 76 (1994), pp. 253-262
[29.]
I.M. Adcock, C.R. Brown, H. Shirasaki, P.J. Barnes.
Effects of dexamethasone on cytokine and phorbol ester stimulated c-Fos and c-Jun DNA binding and gene expression in human lung.
Eur Respir J, 7 (1994), pp. 2.117-2.123
[30.]
I.M. Adcock, C.R. Brown, C.M. Gelder, H. Shirasaki, M.J. Peters, P.J. Barnes.
Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells.
Am J Physiol, 268 (1995), pp. C331-C338
[31.]
I.M. Adcock, P.J. Barnes.
Actions of the glucocorticoid receptor on transcription factors within the cytoplasma.
Am J Respir Crit Care Med, 151 (1995), pp. A195
[32.]
R.I. Scheinman, A. Gualberto, C.M. Jewell, J.A. Cidlowski, A.S. Baldwin Jr..
Characterization of mechanisms involved in transrepression of NF-kB by activated glucocorticoid receptors.
Mol Cell Biol, 15 (1995), pp. 943-953
[33.]
F. Imai, J.N. Minger, J.A. Mitchell, K.R. Yamamoto, D.K. Granner.
Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids.
J Biol Chem, 268 (1993), pp. 5.353-5.356
[34.]
M.J. Peters, I.M. Adcock, C.R. Brown, P.J. Barnes.
Beta-adrenoceptor agonists interfere with glucocorticoid receptor DNA-binding in rat lung.
Eur J Pharmacol (Mol Pharm), 289 (1995), pp. 275-281
[35.]
P.M. Guyre, M.T. Girard, P.M. Morganelli, P.D. Manginiello.
Glucocorticoid effects on the production and action of immune cytokines.
J Steroid Biochem, 30 (1988), pp. 89-93
[36.]
J.A. Kem, R.J. Lamb, J.L. Reed, R.P. Daniele, P.L. Nowell.
Dexamethaso-ne inhibition of interleukin-l-beta production by human monocytes.
Post-transcriptional mechanisms. J Clin Invest, 81 (1988), pp. 237-244
[37.]
K. Grabstein, S. Dower, S. Gillis, V. Urdal, A. Larsen.
Expression of interleukin-2, interferon-γ, and the IL-2 receptor by human peripheral blood lymphocytes.
J Immunol, 136 (1986), pp. 4.503-4.508
[38.]
M.W. Radomski, R.M.J. Palmer, S. Moneada.
Glucocorticoids inhibit the expression of an inducible, but not the constitutive nitric oxide synthase in vascular endothelial cells.
Proc Natl Acad Sci USA, 87 (1990), pp. 10.043-10.049
[39.]
S.H. Peers, F. Smillie, A.J. Elderfield, R.J. Flower.
Glucocorticoid-andnon-glucocorticoid induction of lipocortins (annexins) 1 and 2 in rat peritoneal leucocytes in vivo.
Br J Pharmacol, 108 (1993), pp. 66-72
[40.]
C. Schalkwijk, M. Vervoordeldonk, J. Pfeilschifter, F. Marki, H. Vanden Bosch.
Cytokineand forskolin-induced synthesis of group II phospholipase A2 and prostaglandin E, in rat mesangial cells is prevented hy dexamethasone.
Biochem Biophys Res Commun, 180 (1991), pp. 46-52
[41.]
M.K. O’Banion, V.D. Winn, D.A. Young.
cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.
Proc Natl Acad Sci USA, 89 (1992), pp. 4.888-4.892
[42.]
D.B. Borson, S. Jew, D.C. Gruenert.
Glucocorticoids induce neutral endopeptidase in transformed human tracheal epithelial cells.
Am J Physiol, 260 (1991), pp. L83-L89
[43.]
J. Stankova, M. Rola-Pleszczynski.
Leukotriene B4 stimulates c-fos and c-jun gene transcription and AP-1 binding activity in human monocytes.
Biochem J, 282 (1992), pp. 625-629
[44.]
J.C. Mak, M. Nishikawa, P.J. Barnes.
Glucocorticosteroids increase beta 2-adrenergic receptor transcription in human lung.
Am J Physiol, 268 (1995), pp. L41-L46
[45.]
I.M. Adcock, M. Peters, C. Gelder, H. Shirasaki, C.R. Brown, P.J. Barnes.
Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids.
J Mol Endocrinol, 11 (1993), pp. 1-7
[46.]
B.N. Cronstein, S.C. Kimmel, R.I. Levin, F. Martiniuk, G. Weissmann.
A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1.
Proc Natl Acad Sci USA, 89 (1992), pp. 9.991-9.995
[47.]
A. Xaubet, J. Mullol, E. López, J. Roca-Ferrer, M. Rozman, M. Carrión, et al.
Comparison of the role of nasal polyp and normal nasal mucosal epithelial cells on in vitro eosinophil survival. Mediation by GM-CSF and inhibition of dexamethasone.
Clin Exp Allergy, 24 (1994), pp. 307-317
[48.]
A. Xaubet, J. Mullol, J. Roca-Ferrer, E. López, J.C. Fernández, C. Picado.
Effects of topical steroids on cytokine release from human nasal epithelial cells in vitro.
Am J Respir Crit Care Med, 151 (1995), pp. A367
[49.]
G.P. Owens, W.E. Hahn, J.J. Cohen.
Identification of mRNAs associated with programmed cell death in immature thymocytes.
Mol Cell Biol, 11 (1991), pp. 4.177-4.188
[50.]
N. Wallen, H. Kita, D. Weiler, G.J. Gleich.
Glucocorticoids inhibit cytokine-mediated eosinophil survival.
J Immunol, 147 (1991), pp. 3.490-3.495
[51.]
R. Carnuccio, M. Di Rosa, B. Guerrasio, T. Iuvone, L. Satebin.
Vasocort: a novel glucocorticoid-induced anti-inflammatory protein.
Br J. Pharmacol, 90 (1987), pp. 443-445
[52.]
J.D. Lundgren, F. Hirata, Z. Marom, C. Logun, L. Steel, M. Kaliner, et al.
Dexamethasone inhibits respiratory glycoconjugate secretion from feline airways in vitro by the induction of lipocortin (lipomodulin) synthesis.
Am Rev Respir Dis, 137 (1988), pp. 353-357
[53.]
S. Shimura, T. Sasaki, K. Ikeda, K. Yamauchi, H. Sasaki, T. Takishima.
Direct inhibitory action of glucocorticoids on glycoconjugate secretion from airway submucosal glands.
Am Rev Respir Dis, 141 (1990), pp. 1.044-1.049
[54.]
S.J. Pilkis, D.K. Granner.
Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis.
Annu Rev Physiol, 54 (1992), pp. 885-909
[55.]
G.P. Chrousos.
The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation.
N Engl J Med, 332 (1995), pp. 1.351-1.362
[56.]
J. Mullol, A. Xaubet, E. López, J. Roca-Ferrer, J.M. Fabra, C. Picado.
Effect of systemic and inhaled glucocorticoid on eosinophil survival induced by epithelial cells from inflammatory and non-inflammatory respiratory mucosa.
Thorax, 50 (1995), pp. 270-274
[57.]
J.D. Adachi, W.G. Bensen, A.B. Hodsman.
Corticosteroid-induced osteoporosis.
Semin Arthritis Rheum, 22 (1993), pp. 375-384
[58.]
S.H. Mellon.
Neurosteroids: biochemistry, modes of action, and clinical relevance.
J Clin Endocrinol Metab, 78 (1994),
[59.]
H.J. Schwartz, F.C. Lowell, J.C. Melby.
Steroid resistance in bronchial asthma.
Am J Int Med, 69 (1968), pp. 493-499
[60.]
S.W. Lamberts, J.W. Koper, F.H. De Jong.
Familial and iatrogenic cortisol receptor resistance.
J Steroid Biochem Mol Biol, 43 (1992), pp. 385-388
[61.]
S. Szefler.
Glucocorticoid therapy for asthma: clinical pharmacology.
J Allergy Clin Immunol, 88 (1991), pp. 147-165
[62.]
C.J. Corrigan, P.H. Brown, N.C. Barnes, S.J. Szefler, J.J. Tsai, A.J. Frew, et al.
Glucocorticoid resistance in chronic asthma. Glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in vitro.
Am Rev Respir Dis, 144 (1991), pp. 1.016-1.025
[63.]
J. Álvarez, W. Surs, D.Y. Leung, D. Ikle, E.W. Gelfand, S.J. Szefler.
Steroid-resistant asthma: immunologic and pharmacologic features.
J Allergy Clin Immunol, 89 (1992), pp. 714-721
[64.]
E.R. Sher, D.Y.M. Leung, W. Surs, J.C. Kam, G. Zieg, A.K. Kamada, et al.
Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy.
J Clin Invest, 93 (1994), pp. 33-39
[65.]
J.C. Kam, S.J. Szefler, W. Surs, F.R. Sher, D.Y.M. Leung.
Combination of IL-2 and IL-4 reduces glucocorticoid-receptor binding affinity and T cell response to glucocorticoid.
J Immunol, 151 (1993), pp. 3.460-3.466
[66.]
J.D. Spahn, D.Y.M. Leung, W. Surs, R.J. Harbeck, S. Nimmagadda, S.J. Szefler.
Reduced glucocorticoid binding affinity in asthma is related to ongoing allergic inflammation.
Am J Respir Crit Care Med, 151 (1995), pp. 1.709-1.714
[67.]
K.F. Chung, M.R. Podgorski, N.J. Goulding, J.L. Godolphin, P.R. Sharland, B. O’Connor, et al.
Circulating autoantibodies to recombinant lipocortin-1 in asthma.
Respir Med, 85 (1991), pp. 121-124
[68.]
I.M. Adcock, S.J. Lane, C.R. Brown, M.J. Peters, T.H. Lee, P.J. Barnes.
Differences in binding of glucocorticoid receptor to DNA in steroid-resistant asthma.
J Immunol, 154 (1995), pp. 3.500-3.505
[69.]
I.M. Adcock, S.J. Lane, C.R. Brown, T.H. Lee, P.J. Barnes.
Abnormal glucocorticoid receptor-interaction in steroid-resistant asthma.
J Exp Med, 182 (1995), pp. 1.951-1.958
[70.]
R. Schüle, R.M. Evans.
Cross-coupling of signal transduction pathways: zinc finger meets leucine zipper.
Trends Genet, 7 (1991), pp. 377-381
[71.]
I.M. Adcock, M.J. Peters, C.R. Brown, D.A. Stevens, P.J. Barnes.
High concentrations of beta-adrenergic agonists inhibit DNA binding of glucocorticoids in human lung in vitro.
Biochem Soc Trans, 23 (1995), pp. 217
[72.]
National Heart. Lung Blood Institute.
National Asthma Education Program. Expert Panel Report. Guidelines for the diagnosis and management of asthma.
J Allergy Clin Immunol, 83 (1991), pp. 425-534
[73.]
R.A. Goldstein, W.E. Paul, D.D. Metcalfe, W.W. Busse, E.R. Reece.
Asthma\.
Ann Intern Med, 121 (1994), pp. 698-708
[74.]
Drugs used in the treatment of asthma.
Goodman & Gilman's the pharmacological basis of therapeutics., pp. 659-682
[75.]
International Rhinitis Management Group.
International Consensus Report on the diagnosis and management of rhinitis, 49 (1994), pp. 5-34
[76.]
V.J. Lund.
Practical application of the international consensus on the management of rhinitis.
Clin Immunother, 4 (1995), pp. 270-278
[77.]
Position statement on nasal polyposis.
Rhinology, 32 (1994), pp. 1.256
[78.]
B.J. Lipworth.
Clinical pharmacology of corticosteroids in bronchial asthma.
Pharmacol Ther, 58 (1993), pp. 173-209
[79.]
A.M. Taburet, B. Schmit.
Pharmacokinetic optimisation of asthma treatment.
Clin Pharmacokinet, 26 (1994), pp. 396-418
[80.]
P.J. Barnes.
Inhaled glucocorticoids for asthma.
N Engl J Med, 332 (1995), pp. 868-875
[81.]
M.R. Sears, D.R. Taylor, C.G. Print, D.G. Lake, Q. Li, E.M. Flannery, et al.
Regular inhaled beta-agonist treatment in hronchial asthma.
Lancet, 336 (1990), pp. 1.391-1.396
[82.]
A.E. Tattersfield, P.J. Barnes.
β2-agonists and corticosteroids: new developments and controversies.
Am Rev Respir Dis, 146 (1992), pp. 1.637-1.641
[83.]
A.O. Davies, R.J. Lefkowitz.
Regulation of β-adrenergic receptors by steroid hormones.
Annu Rev Physiol, 46 (1984), pp. 119-130
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