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Vol. 60. Issue 8.
Pages 483-489 (August 2024)
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Vol. 60. Issue 8.
Pages 483-489 (August 2024)
Original Article
Factors Associated With Change in S3-NIV Score Over Time in People With Chronic Respiratory Failure Treated With Long-Term Home Noninvasive Ventilation
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Messaoud Lefouilia,b, Nathalie Arnolb, Sandra Journetb, Pascal Chauderonb, Dan Adlerd, Jean-Paul Janssense, Jean-Louis Pépina,c, Sébastien Baillya,c,1, Jean Christian Borelb,1,
Corresponding author
j.borel@agiradom.com

Corresponding author.
a HP2 Laboratory, INSERM U1300, University Grenoble Alpes, Grenoble 38000, France
b AGIR à dom, Homecare Charity, Meylan 38240, France
c EFCR Laboratory, Grenoble Alpes University Hospital, Grenoble 38000, France
d Division of Lung Diseases, Hôpital de la Tour, 1217 Meyrin, Geneva, Switzerland
e Cardio-Respiratory Center, Hôpital de la Tour, 1217 Meyrin, Geneva, Switzerland
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Table 1. Baseline characteristics of participants.
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Abstract
Introduction

Monitoring changes in symptoms over time during long-term nocturnal home non-invasive ventilation (NIV) using patient-reported outcome measures is crucial. This study aimed to identify factors associated with changes in the S3-NIV total score, its two domains (“respiratory symptoms” and “sleep and NIV-related side effects”) and individual item responses.

Methods

We conducted a retrospective, longitudinal data analysis of a cohort of adults with chronic respiratory failure treated with NIV. Data were obtained from a French homecare provider. Multivariate linear and multinomial ordinal mixed effect models were used to identify factors associated with changes in S3-NIV scores over time.

Results

Median follow-up was 2 years for 2135 participants. Each participant completed a median of five S3-NIV questionnaires; totaling 11,359 analyzed questionnaires. Type of respiratory condition, sex, age and time since NIV initiation were associated with change in S3-NIV score over time. NIV adherence was not associated with total S3-NIV score but high adherence was associated with more severe respiratory symptoms and an improvement in sleep and NIV-related side effects during the follow-up. Intensity of pressure support was associated with a lower total S3-NIV score and more side effects. Face masks and supplemental oxygen were associated with a lower S3-NIV total score.

Conclusion

Changes in S3-NIV scores over time are associated with the individual's characteristics and NIV settings. Analysis of the two domains and individual items of the S3-NIV could increase understanding of the difficulties experienced by people on NIV.

Keywords:
Noninvasive ventilation
Patient reported outcome measures
Respiratory insufficiency
Abbreviations:
ASV
BMI
BURR
COPD
CRF
PEP
HRQoL
IQR
NIV
OHS
OR
SD

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