Journal Information
Vol. 36. Issue 8.
Pages 441-449 (September 2000)
Share
Share
Download PDF
More article options
Vol. 36. Issue 8.
Pages 441-449 (September 2000)
Full text access
Utilidad del cuestionario de síntomas respiratorios IUATLD para el diagnóstico diferencial del asma bronquial y la bronquitis crónica
Usefulness of the IUATLD respiratory symptoms questionnaire for the differential diagnosis of bronchial asthma and chronic bronchitis
Visits
17046
M. León Fábregas*, A. de Diego Damiá, M. Perpiñá Tordera
Servicio de Neumología. Hospital Universitario La Fe. Valencia
This item has received
Article information
Abstract
Bibliography
Download PDF
Statistics

Nuestro objetivo fue conocer el valor diagnóstico del cuestionario de la IUATLD para diferenciar pacientes con asma bronquial y bronquitis crónica. Para ello las respuestas de 211 pacientes fueron validadas frente al diagnóstico clínico establecido de forma independiente por 2 neumólogos. Las preguntas se incluyeron en un análisis discriminante utilizando como variables independientes las respuestas y como variable dependiente el diagnóstico. La capacidad predictiva individual de cada pregunta y de las funciones discriminantes que agrupaban los mejores módulos de preguntas se calcularon con un análisis bayesiano. Finalmente se compararon con pruebas que valoraban: función pulmonar (espirometría); variabilidad de la obstrucción (test broncodilatador, peak flow, test de provocación bronquial); atopia (prick test, IgE sérica), y parámetros clínicos y biológicos (eosinofilia). Este cuestionario conseguía diagnosticar correctamente al 91% de los pacientes, y utilizando únicamente 5 preguntas la sensibilidad (85,6%), especificidad (91,4%), valor predictivo positivo (93,1%) y valor predictivo negativo (82,2%) superaban a los del resto de pruebas. Estos resultados, junto a la sencillez de su manejo, nos permiten considerar a este cuestionario como una buena herramienta para el diagnóstico de asma bronquial frente a bronquitis crónica.

Palabras clave:
Cuestionarios
Asma bronquial
Bronquitis crónica

Our objective was to determine the diagnostic value of the questionnaire devised by the International Union against Tuberculosis and Lung Disease (IUATLD) for distinguishing between bronchial asthma and chronic bronchitis. We therefore compared clinical diagnoses established independently by two pneumologists for 211 patients to the patients’ responses to the IUATLD questionnaire. The questions were analyzed for their ability to discriminate using the responses as independent variables and the diagnosis as the dependent variable. The individual predictive capacity of each question and the discriminating functions that identified the best clusters of questions were calculated using bayesian analysis. Finally, we compared IUATLD results to tests that assessed lung function (spirometry), obstruction variability (bronchodilator test, peak flow, bronchial challenge test), atopy (prick test, serum IgE), and clinical and biological markers (eosinophilia). The questionnaire correctly diagnosed 91% of the patients and a cluster of five questions registered a sensitivity of 85.6%, specificity of 91.4%, a positive predictive value of 93.1% and a negative predictive value of 82.2%, thus proving superior to the other tests. These results, along with the ease of administering the questionnaire allows us to consider the IUATLD instrument to be a good tool for the differential diagnosis of bronchial asthma and chronic bronchitis.

Key words:
Questionnaires
Bronchial asthma
Chronic bronchitis
Full text is only aviable in PDF
Bibliografía
[1.]
P.G.J. Burney, S. Chinn, J.R. Britton, A.E. Tattersfield, A.O. Papacosta.
What symptoms predict the bronchial response to histamine?.
Evaluation in a community survey of the Bronchial Symptoms. Questionnaire (1984) of the International Union Against Tuberculosis and Lung Disease. Int J Epidemiol, 18 (1989), pp. 165-173
[2.]
American Thoracic Society.
Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma.
Am Rev Respir Dis, 136 (1987), pp. 225-244
[3.]
J. Sanchis Aldás, P. Casán Clara, J. Castillo Gómez, N. González Mangado, L. Palenciano Ballesteros, J. Roca Torrent.
SEPAR.
Normativa para la espirometría forzada, Doyma, (1987),
[4.]
J. Roca.
Spirometric reference values for a mediteranean population.
Bull Eur Physiopathol Respir, 18 (1982), pp. 101-102
[5.]
J. Sanchis Aldás, P. Casán Clara, J. Castillo Gómez, N. González Mangado, L. Palenciano Ballesteros, J. Roca.
SEPAR.
Recomendaciones SEPAR, pp. 1-18
[6.]
A. Valencia, P. Casan, M. Díaz, M. Perpiñá, D. Sebastián.
Normativa para los tests de provocación bronquial inespecífica.
Doyma, (1987),
[7.]
P.J. Sterk.
Airway responsiveness.
Eur Respir J, 6 (1993), pp. 53-83
[8.]
D.W. Cockroft, D.N. Killian, J.A. Mellon, F.E. Hargreave.
Bronchial reactivity to inhaled histamine: a method and clinical survey.
Clin Allergy, 7 (1977), pp. 235-243
[9.]
A.J. Nunn, I. Gregg.
New regression equeations for predicting peak expiratory flow in adults.
Br Med J, 298 (1989), pp. 1068-1070
[10.]
B.G. Higging, J.R. Britton, S. Chinn, T.D. Jones, D. Jenkinson, P.G. Burney, et al.
The distribution of peak expiratory flow in a population sample.
An Rev Respir Dis, 140 (1989), pp. 1368-1372
[11.]
H.K. Reddel, C.M. Salome, J.K. Peat, A.J. Woolcock.
Which index of peak expiratory flow is most useful in the management of stasma bronquialle asthma?.
Am J Respir Crit Med, 151 (1995), pp. 1320-1325
[12.]
S. Dreborg, A. Frew.
Alergen standardization in prick tests.
Allergy, 48 (1993), pp. 24-31
[13.]
G.R. Norman, D.L. Streiner.
Bioestadística.
Mosby/Doyma Libros, (1996),
[14.]
R.A. Barbee, M. Halonen, W. Kalternborn, M.D. Lebowitz, B. Burrows.
A longitudinal study of serum IgE in a community cohort: correlation with age, sex, smoking, and atopic status.
J Allergy Clin Immunol, 79 (1987), pp. 919-927
[15.]
S. Chinn.
Report on the development of the IUATLD asthma questionnaire.
Bull Int U Against Tub Lung Disease, 62 (1987), pp. 45-46
[16.]
M.J. Hensley, N.A. Saunders, J.H. Wlodarezyk.
Evaluation of a new asthma questionnaires.
J Asthma, 28 (1991), pp. 129-139
[17.]
P.G.J. Burney, L.A. Laitinen, S. Perdrizet, H. Huckauf, A.E. Tattersfield, S. Shinn, et al.
Validity and repeatasma bronquialility of the IUALTD (1984) bronchial symtoms questionnaire: an international comparison.
Eur Respir J, 2 (1989), pp. 940-945
[18.]
P.G.J. Burney, S. Chinn.
Developing a new questionnaire for measuring the prevalence and distribution of asthma.
Chest, 91 (1987), pp. 79S-83S
[19.]
Grupo Español para el Estudio Europeo del Asma Bronquial.
Med Clin (Barc), 104 (1995), pp. 487-492
[20.]
L.K. Josephs, I. Gregg, M.A. Mullee, S.T. Holgate.
Nonspecific bronchial reactivity and its relationship to the clinical expresion of astma.
Am Rev Respir Dis, 140 (1989), pp. 350-357
[21.]
A.N.P. Speight, D.A. Lee, E.N. Hey.
Underdiagnosis and undertreatment of asthma in childhood.
Br Med J, 286 (1983), pp. 1253-1256
[22.]
C.I. Panhuysen, E.R. Bleecker, G.H. Koeter, D.A. Meyers, D.S. Postma.
Characterization of obstructive airway disease in family members of probands with asthma.
An algorithm for the diagnosis of asthma. Am J Respir Crit Care Med, 157 (1998), pp. 1734-1742
[23.]
B. Burrows, R.A. Barbee, M.G. Cline, R.J. Knudson, M.D. Lebowitz.
Characteristics of asthma among elderly adults in a sample of general population.
Chest, 100 (1991), pp. 935-942
[24.]
A.B. Murray, B.J. Morrison.
The decrease in severity of asthma in children of parents who smoke since the parents have been exposing them to less cigarrete smoke.
J Allergy Clin Immunol, 91 (1993), pp. 102-110
[25.]
S.M. Brugman, G.L. Larsen.
Asthma in infants and small Children.
En: Asthma. Clinics in Chest Medicine, 4 (1995), pp. 637-656
[26.]
G.T. O’Connor, D. Sparrow, M.R. Segal, S.T. Weiss.
Smoking, atopy, and methacholine airway responsiveness among middle-aged and elderly men.
Am Rev Respir Dis, 140 (1989), pp. 1520-1526
[27.]
C.H. Bodner, S. Ross, J. Little, G. Douglas, J.S. Legge, J.A.R. Friend, et al.
Risk factors for adult onset wheeze.
Am J Respir Crit Care Med, 157 (1998), pp. 35-42
[28.]
J.L. Ohman, D. Sparrow, M.R. MacDonald.
New onse wheezing in an older male population: evidence of allergene sensitization in a longitudinal study.
J Allergy Clin Immunol, 91 (1993), pp. 752-757
[29.]
J. Sunyer, J.M. Antó, M. Kogevinas, J.B. Soriano, A.M. Tobías, A. Muñoz.
Smoking and bronchial responsiveness in non-atopic and atopic young adults.
Thorax, 52 (1997), pp. 235-238
[30.]
H.A. Thiadens, G.H. De Bock, F.W. Dekker, J.A.N. Huysman, J.C. Van Houwelingen, M.P. Springer, et al.
Identifying asthma and chronic obstructive pulmonary disease in patients with persistent cough presenting to general practitioners: descriptive study.
Br Med J, 316 (1998), pp. 1286-1290
[31.]
P. Weiner, R. Magadle, J. Waizman, M. Weiner, M. Rabner, D. Zamir.
Characteristics of asthma in the elderly.
Eur Respir J, 12 (1998), pp. 564-568
[32.]
R.A. Shaw, J. Crane, N. Pearce, C.D. Burguess, P. Bremner, K. Woodman, et al.
Comparison of a video questionnaire with the IUATLD written questionnaire for measuring asthma prevalence.
Clin Exp Allerg, 22 (1992), pp. 561-568
[33.]
K. Torén, J.H. Brisman, K. Järvholm.
Asthma and asthma-like symptoms in adult assessed by questionnaires.
Chest, 104 (1993), pp. 600-608
[34.]
European Community Respiratory Health Survey.
Variations in the prevalence of respiratory symptoms, self-reported asthma attacks, and use of asthma medication in the European Community Respiratory Health Survey (ECRHS).
Eur Respir J, 9 (1996), pp. 687-695
[35.]
M.J. Abramson, M.J. Hensley, N.A. Saunders, J.H. Wlodarczyk.
Evaluation of a new asthma questionnaire.
J Asthma, 28 (1991), pp. 129-139
Copyright © 2000. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?