Journal Information
Vol. 45. Issue 5.
Pages 212-217 (May 2009)
Share
Share
Download PDF
More article options
Vol. 45. Issue 5.
Pages 212-217 (May 2009)
Original article
Full text access
Usefulness of Radial Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for the Diagnosis of Mediastinal Lymph Nodes
Utilidad de la punción aspirativa transbronquial guiada con ultrasonografía endobronquial (USEB) radial para el diagnóstico de adenopatías mediastínicas
Visits
4744
Albert Sánchez-Fonta,
Corresponding author
ASanchezF@imas.imim.es

Corresponding author.
, Víctor Curulla, Iván Vollmerb, Lara Pijuanc, Ángel Gayeteb, Joaquim Geaa
a Servei de Pneumologia, Hospital del Mar-IMIM, Universitat Autònoma de Barcelona, Universitat Pompeu Fabra, CIBER (Centro de Investigación Biomédica en Red) de Enfermedades Respiratorias (CibeRes), Barcelona, Spain
b Servei de Radiodiagnòstic, Hospital del Mar-IMIM, Universitat Autònoma de Barcelona, Universitat Pompeu Fabra, CIBER (Centro de Investigación Biomédica en Red) de Enfermedades Respiratorias (CibeRes), Barcelona, Spain
c Servei d’Anatomia Patològica, Hospital del Mar-IMIM, Universitat Autònoma de Barcelona, Universitat Pompeu Fabra, CIBER (Centro de Investigación Biomédica en Red) de Enfermedades Respiratorias (CibeRes), Barcelona, Spain
This item has received
Article information
Abstract
Bibliography
Download PDF
Statistics
Abstract
Introduction

Transbronchial needle aspiration (TBNA) is a bronchoscopic technique that has been shown to be useful for sampling mediastinal lymph nodes. The yield of this technique can be increased by using endobronchial ultrasound (EBUS) to guide needle placement. The aim of the present study was to compare the yield of EBUS-guided TBNA to that of conventional TBNA in the analysis of mediastinal lymph nodes.

Patients and Methods

All patients undergoing either EBUS-guided or conventional TBNA for the diagnosis of mediastinal lymph nodes between January 2006 and May 2007 were studied consecutively. Histology results were used as a reference standard in patients treated surgically. In cases in which surgery was not indicated, the results of cytology or of clinical follow-up of at least 6 months duration were used.

Results

TBNA was performed in 117 patients and a total of 143 lymph nodes were punctured (mean shortest [SD] diameter, 17.9 [8] mm). The samples obtained were diagnostic in 58 patients (49.6%) and in 70 lymph nodes (49.0%). For paratracheal and hilar stations, the yield of EBUS-guided TBNA was superior to that of conventional TBNA (59.2% compared to 34.1%, P=.02).

Conclusions

Radial EBUS guidance increases the diagnostic yield of TBNA in paratracheal and hilar lymph node stations.

Keywords:
Endobronchial ultrasound (EBUS)
Transbronchial needle aspiration (TBNA)
Mediastinal lymph nodes
Staging
Lung cancer
Resumen
Introducción

La punción aspirativa transbronquial (PATb) es una técnica broncoscópica que ha demostrado ser de utilidad para la obtención de muestras citohistológicas de adenopatías mediastínicas. La ultrasonografía endobronquial (USEB) permite realizar una punción orientada e incrementar de esta forma el rendimiento de la técnica. El objetivo del presente trabajo ha sido comparar el rendimiento de la PATb guiada con USEB radial con la realizada de forma convencional, en el estudio de adenopatías mediastínicas.

Pacientes y métodos

Se incluyó consecutivamente a todos los pacientes a quienes se realizó PATb para el estudio de adenopatías mediastínicas, fuera de forma convencional o guiada con USEB radial, desde enero de 2006 hasta mayo de 2007. Se utilizó como referencia el resultado histológico en los pacientes intervenidos quirúrgicamente y el resultado de la citología y seguimiento clínico, durante un mínimo de 6 meses, en los casos en que la cirugía no estaba indicada.

Resultados

Se realizó PATb a 117 pacientes, con un total de 143 adenopatías puncionadas (diámetro menor medio ± desviación estándar: 17,9 ± 8 mm). El material obtenido permitió el diagnóstico en 58 pacientes (49,6%) y en 70 ganglios (49,0%). Para las estaciones paratraqueales e hiliares, el rendimiento de la PATb guiada con USEB radial fue superior al de la PATb convencional (un 59,2 frente a un 34,1%; p = 0,02).

Conclusiones

La USEB radial incrementa el rendimiento diagnóstico de la PATb en las estaciones ganglionares paratraqueales e hiliares.

Palabras clave:
Ultrasonografía endobronquial (USEB) radial
Punción aspirativa transbronquial (PATb)
Adenopatías mediastínicas
Estadificación
Cáncer de pulmón
Full text is only aviable in PDF
References
[1.]
A. Spira, D.S. Ettinger.
Multidisciplinary management of lung cancer.
N Engl J Med, 350 (2004), pp. 379-392
[2.]
C.F. Mountain, C.M. Dresler.
Regional lymph node classification for lung cancer staging.
Chest, 111 (1997), pp. 1718-1723
[3.]
F.C. Detterbeck, M.M. DeCamp Jr, L.J. Kohman, G.A. Silvestri.
Lung cancer. Invasive staging: the guidelines.
Chest, 123 (2003), pp. 167S-175S
[4.]
A. Ernst, S.P. Gangadharan.
A good case for a declining role for mediastinoscopy just got better.
Am J Respir Crit Care Med, 177 (2008), pp. 471-472
[5.]
K.P. Wang, R. Brower, E.F. Haponik, S. Siegelman.
Flexible transbronchial needle aspiration for staging of bronchogenic carcinoma.
Chest, 84 (1983), pp. 571-576
[6.]
S. Gasparini, L. Zuccatosta, M. DeNictolis.
Transbronchial needle aspiration of mediastinal lesions.
Monaldi Arch Chest Dis, 55 (2000), pp. 29-32
[7.]
C. Disdier, F. Rodríguez de Castro.
Punción transbronquial aspirativa.
Arch Bronconeumol, 36 (2000), pp. 580-593
[8.]
K.P. Wang.
Staging of bronchogenic carcinoma by bronchoscopy.
Chest, 106 (1994), pp. 588-593
[9.]
J.J. Shannon, R.O. Bude, J.B. Orens, F.S. Becker, R.I. Whyte, J.M. Rubin, et al.
Endobronchial ultrasound-guided needle aspiration of mediastinal adenopathy.
Am J Respir Crit Care Med, 153 (1996), pp. 1424-1430
[10.]
F.J. Herth, W. Lunn, R. Eberhardt, H.D. Becker, A. Ernst.
Transbronchial vs transesophageal ultrasound-guided aspiration of enlarged mediastinal lymph nodes.
Am J Respir Crit Care Med, 171 (2005), pp. 1164-1167
[11.]
F.J. Herth, H.D. Becker, A. Ernst.
Conventional vs endobronchial ultrasound-guided transbronchial needle aspiration: a randomized trial.
Chest, 125 (2004), pp. 322-325
[12.]
F.J. Herth, H.D. Becker, A. Ernst.
Ultrasound-guided transbronchial needle aspiration: an experience in 242 patients.
Chest, 123 (2003), pp. 604-607
[13.]
E.M. Harrow, W. Abi-Saleh, J. Blum, T. Harkin, S. Gasparini, D.J. Addrizzo-Harris, et al.
The utility of transbronchial needle aspiration in the staging of bronchogenic carcinoma.
Am J Respir Crit Care Med, 161 (2000), pp. 601-607
[14.]
E.F. Haponik, D. Sture.
Underutilization of transbronchial needle aspiration: experience of current pulmonary fellows.
Chest, 112 (1997), pp. 251-253
[15.]
E.M. Toloza, L. Harpole, F. Detterbeck, D.C. McCrory.
Invasive staging of non-small cell lung cancer: a review of the current evidence.
Chest, 123 (2003), pp. 157S-166S
[16.]
J.E. Holty, W.G. Kuschner, M.K. Gould.
Accuracy of transbronchial needle aspiration for mediastinal staging of non-small cell lung cancer: a meta-analysis.
Thorax, 60 (2005), pp. 949-955
[17.]
A. Fernández-Villar, F. Iglesias, M. Mosteiro, D. Corbacho, A. González, P. Blanco, et al.
Factores predictores del resultado de la punción-aspiración transtraqueal de adenopatías mediastínicas neoplásicas.
Arch Bronconeumol, 41 (2005), pp. 434-438
[18.]
A.H. Diacon, M.M. Schuurmans, J. Theron, K. Brundyn, M. Louw, C.A. Wright, et al.
Transbronchial needle aspirates: how many passes per target site?.
Eur Respir J, 29 (2007), pp. 112-116
[19.]
D. Baram, R.B. García, P.S. Richman.
Impact of rapid on-site cytologic evaluation during transbronchial needle aspiration.
Chest, 128 (2005), pp. 869-875
[20.]
E. Garpestad, S.N. Goldberg, F. Herth, R. Garland, J. LoCicero III, R. Thurer, et al.
CT fluoroscopy guidance for transbronchial needle aspirations.
Chest, 119 (2001), pp. 329-332
[21.]
F. Rodríguez de Castro, F. Díaz, G. Julià, A. Rey, J. Freixenet, P. Cabrera.
Relevance of training in transbronchial needle aspiration technique.
Chest, 111 (1997), pp. 103-105
[22.]
M.B. Wallace, J. Ravenel, M.I. Block, M. Fraig, G. Silvestri, S. Wildi, et al.
Endoscopic ultrasound in lung cancer patients with a normal mediastinum on computed tomography.
Ann Thorac Surg, 77 (2004), pp. 1763-1768
[23.]
J.T. Annema, M.I. Versteegh, M. Veselic, L. Welker, T. Mauad, J.K. Sont, et al.
Endoscopic ultrasound added to mediastinoscopy for preoperative staging of patients with lung cancer.
JAMA, 294 (2005), pp. 931-936
[24.]
G. Fernández-Esparrach, M. Pellisé, M. Solé, J. Belda, O. Sendino, J. Llach, et al.
Valor de la punción aspirativa con aguja fina guiada por ultrasonografía endoscópica en el diagnóstico de las lesiones mediastínicas.
Arch Bronconeumol, 43 (2007), pp. 219-224
[25.]
P. Martínez-Olondris, M. Molina-Molina, A. Xaubet, R.M. Marrades, P. Luburich, J. Ramírez, et al.
Punción transbronquial aspirativa en el estudio de las adenopatías mediastínicas: rentabilidad y coste-beneficio.
Arch Bronconeumol, 44 (2008), pp. 290-294
[26.]
N.C. Gupta, G.M. Graeber, H.A. Bishop.
Comparative efficacy of positron emision tomography with fluorodeoxyglucose in evaluation of small (< 1 cm), intermediate (1 to 3 cm), and large (>3 cm) lymph node lesions.
Chest, 117 (2000), pp. 773-778
[27.]
F.J.F. Herth, A. Ernst, R. Eberhardt, P. Vilmann, H. Dienemann, M. Krasnik.
Endobronchial ultrasound-guided transbronchial needle aspiration of lymph nodes in the radiologically normal mediastinum.
Eur Respir J, 28 (2006), pp. 910-914
[28.]
E. Monsó, F. Andreo, A. Rosell, P. Cuéllar, E. Castellà, M. Llatjós.
Utilidad de la ultrasonografía endobronquial con punción-aspiración en tiempo real para la estadificación de la neoplasia broncopulmonar.
Med Clin (Barc), 128 (2007), pp. 481-485
[29.]
F.J. Herth, A. Ernst, M. Schulz, H.D. Becker.
Endobronchial ultrasound reliably differentiates between airway infiltration and compression by tumor.
Chest, 123 (2003), pp. 458-462
[30.]
F.J.F. Herth, A. Ernst, H.D. Becker.
Endobronchial ultrasound-guided transbronchial lung biopsy in solitary pulmonary nodules and peripheral lesions.
Eur Respir J, 20 (2002), pp. 972-974
[31.]
F.J. Herth, R. Eberhardt, H.D. Becker, A. Ernst.
Endobronchial ultrasound-guided transbronchial lung biopsy in fluoroscopically invisible solitary pulmonary nodules: a prospective trial.
Chest, 129 (2006), pp. 147-150
Copyright © 2009. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?