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Vol. 27. Issue 5.
Pages 197-201 (June - July 1991)
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Vol. 27. Issue 5.
Pages 197-201 (June - July 1991)
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Tuberculosis e infección por VIH. Analisis de 36 casos
Tuberculosis and infeccion by the human immunodeficiency virus (HIV). Analysis of 36 cases
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P.P. España Yandiola, C. Salinas Solano, M. Oribe Ibañez, J.I. Aguirregomoscorta urquijo, A. Capelastegui Saiz
Unidad de Neumología. Hospital de Galdakao
J. Mayo Suárez*
* Servicio de Medicina Interna. Hospital de Galdakao
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Arch Bronconeumol. 1991;27:38710.1016/S0300-2896(15)31407-1
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Se analizan 36 casos de pacientes hospitalizados con infección por virus de la inmunodeficiencia humana (VIH) y tuberculosis (TBC) en un período de 4 años. La presencia de adicción a drogas por vía parenteral (ADVP) fue el factor de riesgo más importante (97,2%). La presentación más frecuente fue la forma extrapulmonar-diseminada (TBC-ED 77,8%) con respecto a la pulmonar (TBC-P 22,2%). Hubo filiación bacteriológica en 33 casos (91,6%), tipándose en todos los casos M. tuberculosis. Todos los pacientes presentaron fiebre y la sintomatología respiratoria estuvo presente en el 61% de los casos. Predominaron patrones radiológicos pulmonares atípicos, siendo en 10 casos la Rx de ingreso normal (35,7%). La anergia tuberculínica se presentó en el 66% de los pacientes, siendo su relación con los niveles de linfocitos CD4 discriminativa entre los TBC-ED y TBC-P (p<0,05). La respuesta al tratamiento fue buena con escasa reacción adversa al mismo. Los controles analíticos de ácido úrico nos sirvieron como buen marcador de cumplimiento. Hubo 15 abandonos del tratamiento con ocho muertes, aunque sólo una de ellas se debió a la tuberculosis (4%).

This study reports data on 36 patients suffering infection produced by the human immunodeficiency virus and tuberculosis who were hospitalized during a period of 4 years. The most important risk factor in this series was parenteral drug addiction (97,2%). The most frequent clinical presentation was the disseminated extrapulmonary form of tuberculosis (77.8%) as compared with the pulmonary affection (22.2%). In 33 cases (91.6%) bacteriológical investigation revealed the presence of M. tuberculosis in all instances. All patients presented fever and in 61% of cases there were respiratory symptoms. Radiologic patterns were commonly atypical and in 35.7% of patients the chest radiograph on admision was normal. In 66% of cases there was a tuberculin anergia which in combination with the levels of CD4 lymphocites was discri-minative between disseminated extrapulmonary and pulmonary tuberculosis (p<0.05). The response to treatment was good and was not associated with secondary reactions. Plas-matic levels of uric acid were useful in assessing the degree of treatment fulfilment. There were 15 cases of abandonment of the treatment with 8 deaths. Only one death was due to tuberculosis (4%).

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Bibliografía
[1.]
G. Sunderam, R.J. Mcdonald, T. Maniatis, et al.
Tuberculosis as a manifestation of the acquired immunodeficiency syndrome (AIDS).
JAMA, 256 (1986), pp. 362-366
[2.]
J. Cosín, C. Martín-Scapa, J. Menarguez, et al.
SIDA y tuberculosis.
Enf Infec y Microbiol, 5 (1987), pp. 74-80
[3.]
J. Mallolas, X. Latorre, J.M. Gatell, et al.
Análisis clínicos de los primeros 145 casos consecutivos de síndrome de inmunodeficiencia adquirida.
Med Clin (Barc), 91 (1988), pp. 721-724
[4.]
V. Ausina, M.J. Condom.
Tuberculosis y virus de la inmunodeficiencia humana.
Arch Bronconeumol, 23 (1987), pp. 161-163
[5.]
R. Chaisson, G. Scherter, Ch. Theuer, et al.
Tuberculosis in patients with the acquired immunodeficiency syndrome.
Am Rev Respir Dis, 136 (1987), pp. 570-574
[6.]
S. Handweger, D. Mildvan, R. Senie, et al.
Tuberculosis and the acquired immunodeficiency syndrome at New York city hospital: 1978-1985.
Chest, 91 (1987), pp. 176-180
[7.]
Centers for Disease Control.
Diagnosis and management of mycobacterial infection and disease in persons with human immunodcficiency virus infection.
Ann Intern Med, 106 (1987), pp. 254-256
[8.]
M.E. Valencia, P. Lavilla, V. Pintado, et al.
Espectro de las enfermedades por micobacterias en infectados por el virus de la inmunodeficiencia humana.
Arch Bronconeumol, 23 (1987), pp. 6-7
[9.]
C. Algueró, R. Vidal, X. Gracia, et al.
Micobacteriosis en pacientes afectos de SIDA y portadores del anti-VIH.
Arch Bronconcumol, 23 (1987), pp. 7-8
[10.]
J. Cosin, M.C. Martín, J. Gómez, et al.
Tuberculosis e infección por HIV. Revisión de 48 casos.
Rev Clin Esp, 183 (1988), pp. 9-14
[11.]
E. Soriano, J. Mallolas, et al.
Characteristics of tuberculosis in HIV-infected patients; a case-control study.
AIDS, 2 (1988), pp. 429-432
[12.]
C. Perronne, M. Zahraoui, C. Leport, et al.
Tuberculose chez les malades infectes par le virus de 1’immunodeficience humaine. Trente observations.
Press Med, 17 (1988), pp. 1.479-1.483
[13.]
E. Bouza, C. Martín-Scapa, J.C. Bernaldo de Quirós, et al.
High prevalence of tuberculosis in AIDS patients in Spain.
Eur J Clin Microbiol Infect Dis, 7 (1988), pp. 785-788
[14.]
R.L. Coleburnders, R.W. Ryder, N. Nzilambi, et al.
HIV infection in patients with tuberculosis in Kinshasa.
Zaire. Am Rev Respir Dis, 139 (1989), pp. 1.082-1.085
[15.]
H.L. Rieder, G.M. Cauthen, A.B. Bloch, et al.
Tuberculosis and acquired immunodeficiency syndrome.
Florida. Arch Intern Med, 149 (1989),
[16.]
J. Casabona, A. Bosch, T. Salas, et al.
The effect of tuberculosis as a new AIDS definition criterion in epidemiológical surveillance data from a south European área.
J Acquir Immun Defic Syndr, 3 (1990), pp. 272-277
[17.]
CDC.
Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome.
MMWR, 36 (1987), pp. 3s-17s
[18.]
P. March.
Tuberculosis y SIDA. Situación en España. Perspectivas.
Rev Clin Esp, 186 (1990), pp. 365-368
[19.]
P.C. Hopewell.
Tuberculosis and human immunodeficiency virus infection.
Semin Respir Infect, 4 (1989), pp. 111-122
[20.]
R. Vidal Pía.
Patogenia de la tuberculosis en época del SIDA.
II Jomadas de actualización y tuberculosis pulmonar y I reunión del grupo TIR de la SEPAR, (1989),
[21.]
I. Ocaña, A. de Luis, I. Ruiz, et al.
Tuberculose et SIDA en Espagne. V Intemational Conference on AIDS.
Montreal, (1989),
[22.]
A. Pitchenik, C. Cole, Russell Bw, et al.
Tuberculosis, atypical mycobacteriosis, and AIDS among Haitian and non-Haitian patients in South Florida.
Ann Intern Med, 101 (1984), pp. 641-645
[23.]
P.A. Selwyn.
Issues in the clinical management of intravenous drug users with HIV infection.
AIDS, 3 (1989), pp. s201-s208
[24.]
P. Chopewcll.
Prevention of lung infections associated with human immunodeficiency virus infection.
Thorax, 44 (1989), pp. 1.038-1.044
[25.]
G. Goodman.
Las bases farmacológicas de la terapéutica.
7.° ed, española. Ed Medie Panamericana SA, (1988), pp. 1.148-1.149
Copyright © 1991. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
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